Results 51 to 60 of about 548 (160)

Exploring TMPRSS2 Drug Target to Combat Influenza and Coronavirus Infection

Scientifica, Volume 2025, Issue 1, 2025.
Respiratory viral infections, including influenza and coronaviruses, present significant health risks worldwide. The recent COVID‐19 pandemic highlights the urgent need for novel and effective antiviral agents. The host cell protease, transmembrane serine protease 2 (TMPRSS2), facilitates viral pathogenesis by playing a critical role in viral invasion ...
Krishnaprasad Baby, Megh Pravin Vithalkar, Somasish Ghosh Dastidar, Chiranjay Mukhopadhyay, Rania Hamdy, Sameh S. M. Soliman, Yogendra Nayak, Satish Rojekar   +7 more
wiley   +1 more source

Effects of Bromhexine on the Secretions of Saliva and Tears

Japanese Journal of Pharmacology, 1985
Effects of bromhexine and pilocarpine on the secretions of submaxillary saliva in dogs and of tears in rabbits were investigated including their effects on lysozyme activity in an attempt to elucidate the efficacy of bromhexine on Sjögren's syndrome. Pilocarpine (0.3 mg/kg, p.o.) significantly increased spontaneous salivary flow rate, but bromhexine ...
MISAWA, Miwa, OHMORI, Shinji, YANAURA, Saizo   +2 more
openaire   +3 more sources

Tools for clinical pharmacists to identify medications that can cause drug‐induced cognitive impairment: A systematic review

JACCP: JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY, Volume 7, Issue 12, Page 1207-1227, December 2024.
Abstract Cognitive impairment affects around 19% of community‐dwelling older adults in the United States. Pharmacists can play a significant role in identifying and deprescribing cognitive‐impairing medications through cognitive‐focused medication reviews or as part of comprehensive medication management.
Jacob Stanton, Michael R. Gionfriddo, Gail B. Rattinger, Yuan Fang, Mia E. Lussier   +4 more
wiley   +1 more source

Discovery of novel inhibitors for Pseudomonas aeruginosa lipase enzyme from in silico and in vitro studies

, 2023
Pseudomonas aeruginosa is an opportunistic pathogen prone to developing drug-resistance and is a major cause of infection for burn patients and patients suffering from cystic fibrosis or are hospitalized in intensive care units.
Anne Farewell (2937258), Leif A. Eriksson (321332), Asma Gholami (14651461), Dariush Minai-Tehrani (14651464)   +3 more
core   +1 more source

Qualitative analysis of blood from patients engaging in deliberate self‐harm: Differences between prescribed and detected drugs

Neuropsychopharmacology Reports, Volume 44, Issue 4, Page 809-822, December 2024.
In this study, drugs were analyzed from the blood of deliberate self‐harm patients, and the detected drugs were compared with their recent prescribed medications. Of the 55 enrolled patients, 42 (76%) had taken non‐prescribed drugs (NPD), revealing a large discrepancy between prescribed medications and those detected in the blood.
Masato Masuda, Brian Waters, Leo Gotoh, Yoshihiko Nakamura, Yoshifumi Kato, Shigeki Nabeshima, Shin‐ichi Kubo, Nobuaki Eto, Hiroaki Kawasaki   +8 more
wiley   +1 more source

Validated RP-HPLC Method for the Assay of Etoricoxib (A Non-Steroidal Anti-Inflammatory Drug) in Pharmaceutical Dosage Forms

E-Journal of Chemistry, 2012
A simple, accurate, sensitive and reproducible reverse phase high performance liquid chromatographic method has been developed for the quantitative determination of Etoricoxib in pharmaceutical dosage forms.
Srinivasu Topalli, T. G. Chandrashekhar, M. Mathrusri Annapurna   +2 more
doaj   +1 more source

Profil Penggunaan Obat Batuk Pilek Bebas Pada Pasien Anak di Bawah Umur 6 Tahun

Sari Pediatri, 2016
Latar belakang. Obat batuk pilek over the counter (OTC) banyak digunakan secara luas oleh orang tua untuk mengatasi keluhan batuk pilek pada anak. American Academy of Pediatrics (AAP) merekomendasikan untuk tidak menggunakan obat batuk pilek yang dijual ...
Soepardi Soedibyo, Arie Yulianto, Wardhana Wardhana   +2 more
doaj   +1 more source

Comparative Pharmacokinetics and Egg Residues of Amoxicillin, Single and in Combination with Bromhexine, in Laying Hens

Pathogens
The need for antibiotics in commercial laying hens is increasing owing to intensive farming systems. Amoxicillin trihydrate (AMX), an aminopenicillin β-lactam antibiotic, exerts broad bactericidal activity.
Jeong-Won Kim, Ji-Soo Jeong, Jin-Hwa Kim, Chang-Yeop Kim, Eun-Hye Chung, So-Young Boo, Soo-Ha Lee, Je-Won Ko, Tae-Won Kim   +8 more
doaj   +1 more source

Upregulation of key factors of viral entry of corona‐ and influenza viruses upon TLR3‐signaling in cells from the respiratory tract and clinical treatment options by 1,8‐Cineol

Phytotherapy Research, Volume 38, Issue 9, Page 4453-4466, September 2024.
From tissue obtained during surgery, primary cell cultures were established. The different cell cultures were then stimulated with Poly I:C as a model for a viral infection. Subsequently, treatments are carried out with 1,8‐Cineol, Dexamethasone, and Enzalutamide. Target analysis was done using qPCR and flow cytometry analysis.
Leonie Hose, Matthias Schürmann, Holger Sudhoff   +2 more
wiley   +1 more source

ПРИМЕНЕНИЕ МУКОАКТИВНЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВ В ПРАКТИКЕ ТЕРАПЕВТА

Архивъ внутренней медицины, 2013
Russia is among the countries where using of mucolytic drugs in clinical practice is widespread. In chronic bronchitis, chronic obstructive pulmonary disease, acute respiratory syndrome with prolonged cough, pneumonia, tuberculosis and many other ...
Ф. Т. Малыхин, А. А. Визель, И. Ю. Визель   +2 more
doaj   +1 more source