Results 31 to 40 of about 1,283 (170)

Computational Identification of a Putative Allosteric Binding Pocket in TMPRSS2

Frontiers in Molecular Biosciences, 2021
Camostat, nafamostat, and bromhexine are inhibitors of the transmembrane serine protease TMPRSS2. The inhibition of TMPRSS2 has been shown to prevent the viral infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other viruses ...
Jacopo Sgrignani, Andrea Cavalli, Andrea Cavalli   +2 more
doaj   +1 more source

Acute interstitial nephritis observed with three different triggering agents

Clinical Case Reports, 2022
A 70‐year‐old female patient developed acute interstitial nephritis (AIN) after treatment with non‐steroidal anti‐inflammatory drugs (NSAIDs), proton pump inhibitors (PPI), and Bromhexine. Renal biopsy confirmed the diagnosis, and the patient was treated
Niloofar Nobakht, Ramy M. Hanna, Mohammad Kamgar, John Sinclair, Lewis Simon, Sina Emami, Anthony Sisk, Anjay Rastogi   +7 more
doaj   +1 more source

Evaluation of the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol versus a fixed-dose combination of bromhexine/guaifenesin/salbutamol in the treatment of productive cough in adult patients with acute bronchitis

Терапевтический архив, 2023
Aim. To evaluate the efficacy and safety of a combination drug containing ambroxol, guaifenesin, and levosalbutamol, oral solution, versus Ascoril Expectorant, syrup (combination of bromhexine, guaifenesin, and salbutamol) in the treatment of productive ...
Andrey A. Zaitsev, Igor V. Leshchenko, Natalia A. Esaulova, Inna A. Viktorova   +3 more
doaj   +1 more source

Pharmacoeconomic analysis of bromhexine for prophylactic of influenza A and B [PDF]

Pharmacia
The aim of the present analysis is to assess the cost-effectiveness of influenza A and B prophylaxis with bromhexine, used off-label, for the purposes of the healthcare system in Bulgaria.
Guenka Petrova, Vanyo Mitev
doaj   +3 more sources

Development and Validation of Salbutamol, Bromhexine, Ambroxol and Guauaifenesin Determination in Human Plasma by HPLC-MS/MS Method

Разработка и регистрация лекарственных средств, 2019
Introduction. Multicomponent oral drugs containing salbutamol, bromhexine, ambroxol and guaifenesin have a mucolytic, expectorant and bronchodilator effect.
T. N. Komarov, D. S. Bogdanova, O. A. Miskiv, A. V. Aleshina, I. E. Shohin, Yu. V. Medvedev, N. S. Bagaeva, I. M. Korenskaya   +7 more
doaj   +1 more source

Effect of bromhexine in hospitalized patients with COVID-19 [PDF]

Journal of Investigative Medicine, 2023
Background: Bromhexine is a potent inhibitor of transmembrane serine protease 2 and appears to have an antiviral effect in controlling influenza and parainfluenza infection; however, its efficacy in COVID-19 is controversial. Methods: A group of hospitalized patients with confirmed COVID-19 pneumonia were randomized using 1:1 ...
Ramin Tolouian, Zuber D Mulla, Hamidreza Jamaati, Abdolreza Babamahmoodi, Majid Marjani, Raha Eskandari, Farzaneh Dastan   +6 more
openaire   +2 more sources

Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia

Journal of Dental Research, Dental Clinics, Dental Prospects, 2013
Background and aims. Xerostomia is one of the most common complications of head and neck radiotherapy. The aim of this study was to evaluate and compare the efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia and its ...
Farid Abbasi, Sareh Farhadi, Mostafa Esmaili   +2 more
doaj   +1 more source

Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label Study

Interdisciplinary Perspectives on Infectious Diseases, 2022
Background. Bromhexine hydrochloride has been suggested as a TMPRSS2 protease blocker that precludes the penetration of SARS-CoV-2 into cells. We aimed to assess the preventive potential of regular bromhexine hydrochloride intake for COVID-19 risk ...
Evgeny N. Mikhaylov, Tamara A. Lyubimtseva, Aleksandr D. Vakhrushev, Dmitry Stepanov, Dmitry S. Lebedev, Elena Yu. Vasilieva, Alexandra O. Konradi, Evgeny V. Shlyakhto   +7 more
doaj   +1 more source

Comparative in vitro analysis of inhibition of rhinovirus and influenza virus replication by mucoactive secretolytic agents and plant extracts

BMC Complementary Medicine and Therapies, 2020
Background Rhinoviruses and influenza viruses cause millions of acute respiratory infections annually. Symptoms of mild acute respiratory infections are commonly treated with over-the-counter products like ambroxol, bromhexine, and N-acetyl cysteine, as ...
Christin Walther, Kristin Döring, Michaela Schmidtke   +2 more
doaj   +1 more source

Percutaneous Absorption of Bromhexine in Rats.

Chemical and Pharmaceutical Bulletin, 1991
The percutaneous absorption of bromhexine (BH), an expectorant drug, through rat skin was examined in vitro and in vivo. BH in free base form penetrated better than the hydrochloride through the skin. When the in vitro penetration of BH was compared using Plastibase, macrogol and sucrose ester of fatty acid F-160 (DK-ester) formulations, the DK-ester ...
OGISO, Taro, IWAKI, Masahiro, TSUJI, Sachiko   +2 more
openaire   +3 more sources