Results 11 to 20 of about 548 (160)

COVID‐19 Prophylactic Effect of Bromhexine Hydrochloride

Immunity, Inflammation and Disease
Introduction Despite extensive efforts to identify effective treatments for COVID‐19, preventive strategies remain essential. Bromhexine hydrochloride (BRH), an over‐the‐counter mucolytic with potential TMPRSS2 inhibition, may reduce viral entry and thus
Vanyo Mitev, Tsanko Mondeshki, Ani Miteva, Konstantin Tachkov, Violeta Dimitrova   +4 more
doaj   +3 more sources

Efficacy of Pilocarpine and Bromhexine in Improving Radiotherapy-induced Xerostomia

Journal of Dental Research, Dental Clinics, Dental Prospects, 2013
Background and aims. Xerostomia is one of the most common complications of head and neck radiotherapy. The aim of this study was to evaluate and compare the efficacy of pilocarpine and bromhexine in improving radiotherapy-induced xerostomia and its ...
Farid Abbasi, Sareh Farhadi, Mostafa Esmaili   +2 more
doaj   +2 more sources

Effect of bromhexine in hospitalized patients with COVID-19 [PDF]

Journal of Investigative Medicine, 2023
Background: Bromhexine is a potent inhibitor of transmembrane serine protease 2 and appears to have an antiviral effect in controlling influenza and parainfluenza infection; however, its efficacy in COVID-19 is controversial. Methods: A group of hospitalized patients with confirmed COVID-19 pneumonia were randomized using 1:1 ...
Ramin Tolouian, Zuber D Mulla, Hamidreza Jamaati, Abdolreza Babamahmoodi, Majid Marjani, Raha Eskandari, Farzaneh Dastan   +6 more
openaire   +3 more sources

Bromhexine Hydrochloride Prophylaxis of COVID-19 for Medical Personnel: A Randomized Open-Label Study

Interdisciplinary Perspectives on Infectious Diseases, 2022
Background. Bromhexine hydrochloride has been suggested as a TMPRSS2 protease blocker that precludes the penetration of SARS-CoV-2 into cells. We aimed to assess the preventive potential of regular bromhexine hydrochloride intake for COVID-19 risk ...
Evgeny N. Mikhaylov, Tamara A. Lyubimtseva, Aleksandr D. Vakhrushev, Dmitry Stepanov, Dmitry S. Lebedev, Elena Yu. Vasilieva, Alexandra O. Konradi, Evgeny V. Shlyakhto   +7 more
doaj   +2 more sources

Bioavailability of Bromhexine in the Horse

Zentralblatt für Veterinärmedizin Reihe A, 1980
SummaryBromhexine was administered orally (2 mg./kg.) and intravenously (i. v.) (1 mg./kg.) in 3 horses. Plasma levels were measured and the pharmacokinetic behaviour and bioavailability were estimated. The half‐life of elimination after i. v. administration ranged from 3.1 to 4.4 hours.
P, de Backer, L M, Vandecasteele-Thienpont, J A, Jonckheere, F M, Belpaire, M, Debackere, A P, de Leenheer   +5 more
openaire   +3 more sources

Combining kinetics and in silico approaches to evaluate bromhexine as an anti-pancreatic lipase agent for obesity management

Scientific Reports
Industrialization, fast food intake and reduced physical activity, mainly in developed countries, exacerbate obesity and make it a major lifestyle disorder. A promising strategy for developing effective anti-obesity agents is to inhibit pancreatic lipase,
Asma Gholami, Dariush Minai-Tehrani, Leif A. Eriksson   +2 more
doaj   +2 more sources

Electrodeposition of Cobalt Oxides on Carbon Nanotubes for Sensitive Bromhexine Sensing

Molecules, 2022
We develop an electrochemical sensor for the determination of bromhexine hydrochloride (BHC), a widely use mucolytic drug. The sensor is prepared by electrodeposition of cobalt oxides (CoOx) on a glassy carbon electrode modified with carboxylated single ...
Sireerat Lisnund, Vincent Blay, Pratchaya Muamkhunthod, Kittiya Thunyanon, Jaruwan Pansalee, Jirawan Monkrathok, Pachara Maneechote, Kantapat Chansaenpak, Piyanut Pinyou   +8 more
doaj   +2 more sources

Early treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in patients with symptomatic COVID-19: a randomized clinical trialResearch in context [PDF]

EClinicalMedicine
Summary: Background: Repurposed drugs with host-directed antiviral and immunomodulatory properties have shown promise in the treatment of COVID-19, but few trials have studied combinations of these agents.
Dhammika Leshan Wannigama, Cameron Hurst, Phatthranit Phattharapornjaroen, Parichart Hongsing, Natchalaikorn Sirichumroonwit, Kanokpoj Chanpiwat, Ali Hosseini Rad S.M., Robin James Storer, Puey Ounjai, Phitsanuruk Kanthawee, Natharin Ngamwongsatit, Rosalyn Kupwiwat, Chaisit Kupwiwat, James Michael Brimson, Naveen Kumar Devanga Ragupathi, Somrat Charuluxananan, Asada Leelahavanichkul, Talerngsak Kanjanabuch, Paul G. Higgins, Vishnu Nayak Badavath, Mohan Amarasiri, Valerie Verhasselt, Anthony Kicic, Tanittha Chatsuwan, Kashif Pirzada, Farid Jalali, Angela M. Reiersen, Shuichi Abe, Hitoshi Ishikawa, Chanikan Tanasatitchai, Supamat Amphol, Ladda Nantawong, Prangrawee Sangchan, Varissara Sinkajarern, Thutpharritchn Phoonakh, Phornnapat Utenpattanun, Aye Mya Sithu Shein, Timporn Vitoonpong, Nichapha Chongthavonsatit, Yahya Mankong, Piyapong Chaichana, Jenjira Yaithet, Dumrongsak Pongprajak, Sukjai Traimuangpak, Gasit Saksirisampant, Phimonsiri Lamloeskittinon, Adam Adam Hamdy, Sinthu Sinthu Kosasih, Sirirat Sirirat Luk-in   +48 more
doaj   +3 more sources

Nebulization with Bromhexine and Gentamicin For Chronic Rhinitis Accompanied by Multiple Ectoparasite Infestations in a Domestic Cat

Journal of Applied Veterinary Science and Technology
Background: Chronic rhinitis in cats represents a persistent inflammatory condition of the upper respiratory tract, frequently complicated by secondary bacterial infections and exacerbated by comorbidities, such as ectoparasite infestations.
Luh Gede Tasya Pradnya Prastistha, Putu Ayu Sisyawati Putriningsih, I Gusti Made Krisna Erawan   +2 more
doaj   +2 more sources

Pilot survey among patients taking bromhexine prophylactically against influenza

Journal of Family Medicine and Primary Care
Background: The successful use of bromhexine hydrochloride (BRH) for COVID-19 prevention led us to apply the same method for flu prevention. The goal of this study is to observe whether BRH could protect people against influenza.
Vanyo Mitev, Violeta S. Dimitrova, Iva Miteva, Rumen Tiholov, Krasimir Marinov, Ani Miteva, Aleksander I. Lilov, Radoslav Bilyukov, Zornitsa Mihaylova, Nikolay Ishkitiev, Konstantin Tachkov, Tsanko Mondeshki   +11 more
doaj   +2 more sources