Results 11 to 20 of about 1,283 (170)

COVID‐19 Prophylactic Effect of Bromhexine Hydrochloride [PDF]

Immunity, Inflammation and Disease
Introduction Despite extensive efforts to identify effective treatments for COVID‐19, preventive strategies remain essential. Bromhexine hydrochloride (BRH), an over‐the‐counter mucolytic with potential TMPRSS2 inhibition, may reduce viral entry and thus
Vanyo Mitev, Tsanko Mondeshki, Ani Miteva, Konstantin Tachkov, Violeta Dimitrova   +4 more
doaj   +4 more sources

Tissue distribution of bromhexine hydrochloride in broiler chickens following oral administration via drinking water [PDF]

Poultry Science
This study aimed to investigate the tissue distribution of bromhexine hydrochloride in broiler chickens following oral administration via drinking water.
Fang Yang, Jun Liang, Ming-Hui Duan, Yang-Guang Jin, Yue Liu, Yan-Ni Zhang, Xing-Ping Li, Fan Yang   +7 more
doaj   +2 more sources

Bromhexine inhibits SARS-CoV-2 Omicron and variant pseudovirus infection via ACE2-targeted mechanisms [PDF]

Frontiers in Pharmacology
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) causes a highly infectious disease characterized by fever, acute respiratory illness, and pneumonia, known as coronavirus disease 2019 (COVID‐19).
Rafael Zúñiga, Whitney Venturini, Natalia González, Paulina Valenzuela-Hormazábal, Laura Sánchez-Aros, David Ramírez, Angel Cayo, Cristian Vilos, Cristian Vilos, Leandro Zúñiga, Leandro Zúñiga, Leandro Zúñiga   +11 more
doaj   +2 more sources

Bromhexine hydrochloride enhances the therapeutic efficacy of tiamulin against experimental Staphylococcus aureus infection in dogs: targeting bacterial virulence, boosting antioxidant defense, and improving histopathology [PDF]

Frontiers in Pharmacology
IntroductionStaphylococcus aureus is a prominent pathogen capable of causing systemic infections and multi-organ damage, primarily driven by its high virulence and induction of oxidative stress.
Hanem F. El-Gendy, Shimaa R. Masoud, Nagwa I. Sheraiba, Shimaa S. Elnahriry, Doaa A. Madkour, Reda M. S. Korany, Reda M. S. Korany, Hazim O. Khalifa, Hanaa Y. Elnagar   +8 more
doaj   +2 more sources

Research Note: Pharmacokinetics of bromhexine hydrochloride in broilers after single oral and intravenous administration [PDF]

Poultry Science
: The current study aimed to investigate the pharmacokinetics of bromhexine hydrochloride in broilers after single intravenous (IV) and oral (PO) administration at 2.5 mg/kg body weight (BW).
Ming-Hui Duan, Fang Yang, Ze-En Li, Yan Dai, Yang-Guang Jin, Yue Liu, Yan-Ni Zhang, Xing-Ping Li, Fan Yang   +8 more
doaj   +2 more sources

Combining kinetics and in silico approaches to evaluate bromhexine as an anti-pancreatic lipase agent for obesity management [PDF]

Scientific Reports
Industrialization, fast food intake and reduced physical activity, mainly in developed countries, exacerbate obesity and make it a major lifestyle disorder. A promising strategy for developing effective anti-obesity agents is to inhibit pancreatic lipase,
Asma Gholami, Dariush Minai-Tehrani, Leif A. Eriksson   +2 more
doaj   +2 more sources

Comparative Pharmacokinetics and Egg Residues of Amoxicillin, Single and in Combination with Bromhexine, in Laying Hens [PDF]

Pathogens
The need for antibiotics in commercial laying hens is increasing owing to intensive farming systems. Amoxicillin trihydrate (AMX), an aminopenicillin β-lactam antibiotic, exerts broad bactericidal activity.
Jeong-Won Kim, Ji-Soo Jeong, Jin-Hwa Kim, Chang-Yeop Kim, Eun-Hye Chung, So-Young Boo, Soo-Ha Lee, Je-Won Ko, Tae-Won Kim   +8 more
doaj   +2 more sources

Mucoactive Agents in Muco-Obstructive Lung Diseases: A Critical Reappraisal of Pharmacological Effects and Clinical Outcomes [PDF]

Pharmaceuticals
Muco-obstructive lung diseases, such as chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and bronchiectasis, are characterized by the accumulation of highly viscoelastic mucus that compromises mucociliary clearance and fosters ...
Domenico Larobina, Giorgia Franzino, Fabiana Tescione, Michela Abrami, Domenico Tierno, Alice Biasin, Federica Tonon, Anna De Nes, Marta Maggisano, Paola Confalonieri, Annalucia Carbone, Marco Confalonieri, Gabriele Grassi, Sante Di Gioia, Mario Grassi, Massimo Conese   +15 more
doaj   +2 more sources

Early treatment with fluvoxamine, bromhexine, cyproheptadine, and niclosamide to prevent clinical deterioration in patients with symptomatic COVID-19: a randomized clinical trialResearch in context [PDF]

EClinicalMedicine
Summary: Background: Repurposed drugs with host-directed antiviral and immunomodulatory properties have shown promise in the treatment of COVID-19, but few trials have studied combinations of these agents.
Dhammika Leshan Wannigama, Cameron Hurst, Phatthranit Phattharapornjaroen, Parichart Hongsing, Natchalaikorn Sirichumroonwit, Kanokpoj Chanpiwat, Ali Hosseini Rad S.M., Robin James Storer, Puey Ounjai, Phitsanuruk Kanthawee, Natharin Ngamwongsatit, Rosalyn Kupwiwat, Chaisit Kupwiwat, James Michael Brimson, Naveen Kumar Devanga Ragupathi, Somrat Charuluxananan, Asada Leelahavanichkul, Talerngsak Kanjanabuch, Paul G. Higgins, Vishnu Nayak Badavath, Mohan Amarasiri, Valerie Verhasselt, Anthony Kicic, Tanittha Chatsuwan, Kashif Pirzada, Farid Jalali, Angela M. Reiersen, Shuichi Abe, Hitoshi Ishikawa, Chanikan Tanasatitchai, Supamat Amphol, Ladda Nantawong, Prangrawee Sangchan, Varissara Sinkajarern, Thutpharritchn Phoonakh, Phornnapat Utenpattanun, Aye Mya Sithu Shein, Timporn Vitoonpong, Nichapha Chongthavonsatit, Yahya Mankong, Piyapong Chaichana, Jenjira Yaithet, Dumrongsak Pongprajak, Sukjai Traimuangpak, Gasit Saksirisampant, Phimonsiri Lamloeskittinon, Adam Adam Hamdy, Sinthu Sinthu Kosasih, Sirirat Sirirat Luk-in   +48 more
doaj   +2 more sources

Electrodeposition of Cobalt Oxides on Carbon Nanotubes for Sensitive Bromhexine Sensing

Molecules, 2022
We develop an electrochemical sensor for the determination of bromhexine hydrochloride (BHC), a widely use mucolytic drug. The sensor is prepared by electrodeposition of cobalt oxides (CoOx) on a glassy carbon electrode modified with carboxylated single ...
Piyanut Pinyou, Vincent Blay, Kantapat Chansaenpak   +2 more
exaly   +3 more sources