Results 71 to 80 of about 65,001 (335)
Angewandte Chemie, EarlyView.Cyclopropene fatty acids have been made that allow the study of fatty acid uptake in complex mixtures of immune cells with single cell resolution and combined with metabolic and proteomic analysis so that for the first time nutrient uptake can be correlated to the phenotype of single immune cell.
Luuk Reinalda +14 more
wiley +2 more sources
Journal of the American Chemical Society, 2015 The properties of metal-organic frameworks (MOFs) can be tuned by postsynthetic modification (PSM) to introduce specific functionalities after their synthesis.
Ross J. Marshall +3 more
semanticscholar +1 more source
Advanced Science, EarlyView.The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci +13 more
wiley +1 more source
Bromination of deactivated polycyclic aromatic nitro compounds
, 2020 Bromination of 2,7-dinitro-9,10-phenanthrenequinone, 2,5-dinitro-9,10- phenanthrenequinone, and 2,4,7-trinitrofluorenone with bromine in concentrated sulfuric acid in the presence of acetic acid gave, respectively, 4-bromo-2,7-dinitro-9,10 ...
Andrievskii A.M. +3 more
core +2 more sources
Angewandte Chemie, EarlyView.An efficient, enantiodivergent synthesis of phosphorylated oxindoles with quaternary stereocenters is achieved via a nickel‐catalyzed intermolecular Heck‐phosphorylation cascade. Employing a single chiral catalyst, either product enantiomer is selectively accessed simply by changing the alkene leaving group. DFT calculations trace this stereodivergence
Haimeng Zhu +4 more
wiley +2 more sources
Halogenating Enzymes for Active Agent Synthesis: First Steps Are Done and Many Have to Follow
Molecules, 2019 Halogens can be very important for active agents as vital parts of their binding mode, on the one hand, but are on the other hand instrumental in the synthesis of most active agents.
Alexander Veljko Fejzagić +3 more
doaj +1 more source
ESCRT‐Mimetic Nanodegrader Targets STING for Anti‐Inflammatory Therapy
Advanced Science, EarlyView.A nanoplatform‐enabled targeted protein degradation strategy is presented to regulate aberrant STING signaling. STING‐ATTEC induces selective autophagic degradation of STING via formation of a STING–ATTEC–LC3 ternary complex, while the cationic FA‐LNP+ system enhances LC3 generation and targeted delivery. Together, this synergistic approach efficiently
Fuyuan Zhou +9 more
wiley +1 more source
trans-Cyclooctenes as Scavengers of Bromine Involved in Catalytic Bromination
Scavengers that capture reactive chemical substances are used to prevent the decomposition of materials. However, in the field of catalysis, the development of scavengers that inhibit background pathways has attracted little attention, although the ...
Shitamichi, Kenta +5 more
core +1 more source
Occurrence of Acrylamide in Italian Baked Products and Dietary Exposure Assessment
Molecules, 2020 Acrylamide (AA) is a neo-formed toxic compound that develops in foods during cooking at temperatures above 120 °C. AA shows in vivo neurotoxic and carcinogenic effects, and it is potentially carcinogenic for humans. Its occurrence is common in baked food,
Francesco Esposito +4 more
doaj +1 more source
Advanced Science, EarlyView.Quasi‐2D perovskite‐organic segregated‐structure coupling enables low‐power narrowband photomultiplication photodetectors with 110 nm perovskite layer. The optimal device achieves 1200% EQE and 1.82 × 1011 Jones D* at 3 V, offering a new strategy for miniaturized high‐selectivity optoelectronic sensing.
Hongfei Qu +11 more
wiley +1 more source