Results 101 to 110 of about 27,094 (219)

Chromatin Remodeller BRD9 Orchestrates Odontoblastic Differentiation via Coordinating RUNX2‐KLF4

Cell Proliferation, EarlyView.
During odontoblast lineage commitment, the chromatin remodeller BRD9 acts as a critical epigenetic coordinator, orchestrating the chromatin landscape to facilitate synergistic binding of key transcription factors RUNX2 and KLF4 to target loci for odontogenesis.
Wenrui Zeng, Yuxiu Lin, Yongyan Gao, Delan Huang, Yuanyuan Li, Honglei Ruan, Guohua Yuan, Huan Liu, Zhi Chen   +8 more
wiley   +1 more source

Multivalent nucleosome scaffolding by bromodomain and extraterminal domain tandem bromodomains

Journal of Biological Chemistry
Promoter-promoter and enhancer-promoter interactions are enriched in histone acetylation and central to chromatin organization in active genetic regions. Bromodomains are epigenetic "readers" that recognize and bind histone acetylation. Bromodomains often exist in tandem or with other reader domains.
Michael D. Olp, Karina L. Bursch, Sarah L. Wynia-Smith, Raymundo Nuñez, Christopher J. Goetz, Vaughn Jackson, Brian C. Smith   +6 more
openaire   +2 more sources

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Disulfide bridge formation influences ligand recognition by the ATAD2 bromodomain

, 2019
The ATPase family, AAA domain-containing protein 2 (ATAD2) has a C-terminal bromodomain, which functions as a chromatin reader domain recognizing acetylated lysine on the histone tails within the nucleosome. ATAD2 is overexpressed in many cancers and its
Eckenroth, Brian E, Evans, Chiara M, Lloyd, Jonathan T, Gay, Jamie C, Langini, Cassiano, Glass, Karen C; https://orcid.org/, Caflisch, Amedeo, Carlson, Samuel   +7 more
core   +1 more source

Genetic Architecture of Southern Stem Canker Resistance in Elite Southern Soybean (Glycine max [L.] Merr.) Germplasm

Plant Breeding, EarlyView.
ABSTRACT Southern stem canker (SSC), caused by the fungus Diaporthe aspalathi, is one of the major constraints to soybean (Glycine max [L.] Merr.) production in the southern United States and South America. Genetic resistance is the most effective strategy for managing SSC; however, the genetic architecture underlying resistance in elite southern ...
M. Habib Widyawan, James W. Buck, Qijian Song, Zenglu Li   +3 more
wiley   +1 more source

Dynamic chromatin: concerted nucleosome remodelling and acetylation [PDF]

, 2005
The flexibility of chromatin that enables translation of environmental cues into changes in genome utilisation, relies on a battery of enzymes able to modulate chromatin structure in a highly targeted and regulated manner.
Eberharter, Anton, Becker, Peter, Ferreira, Roger   +2 more
core   +1 more source

Bromodomain Proteins Contribute to Maintenance of Bloodstream Form Stage Identity in the African Trypanosome.

PLoS Biology, 2015
Trypanosoma brucei, the causative agent of African sleeping sickness, is transmitted to its mammalian host by the tsetse. In the fly, the parasite's surface is covered with invariant procyclin, while in the mammal it resides extracellularly in its ...
Danae Schulz, Monica R Mugnier, Eda-Margaret Paulsen, Hee-Sook Kim, Chun-wa W Chung, David F Tough, Inmaculada Rioja, Rab K Prinjha, F Nina Papavasiliou, Erik W Debler   +9 more
doaj   +1 more source

Chromatin Remodelling Complexes in Plant Adaptation to Abiotic Stress: Mechanisms and Perspectives

Plant, Cell &Environment, EarlyView.
ABSTRACT As sessile organisms, plants have evolved elaborate epigenetic regulatory networks to adapt to a wide range of abiotic stress. Chromatin remodelling is a core epigenetic regulatory mechanism that refers to the process by which chromatin remodelling complexes mediate dynamic changes in chromatin spatial conformation and DNA accessibility ...
Xiuxiu Zhang, Yueran Zhang, Jiang Li
wiley   +1 more source

Targeting STAT5 in Hematologic Malignancies through Inhibition of the Bromodomain and Extra-Terminal (BET) Bromodomain Protein BRD2

, 2014
The transcription factor signal STAT5 is constitutively activated in a wide range of leukemias and lymphomas, and drives the expression of genes necessary for proliferation, survival, and self-renewal.
Wadleigh, Martha, Frank, David, Toniolo, P. A., Walker, Sarah, Qi, Jun, Stone, Richard, Bradner, James E, Cerulli, R., Nelson, Erik, Liu, Suhu, Xiang, Michael   +10 more
core   +1 more source

Genome‐Wide Association Analysis of Hippocampal Neuroplasticity as an Indicator of Stress Responsiveness in Laying Hens (Gallus gallus domesticus)

Animal Genetics, Volume 57, Issue 5, October 2026.
ABSTRACT Environmental stressors in commercial poultry systems can negatively affect bird welfare, although individuals vary considerably in their responses. Neuroplasticity within the hippocampus, measured through the density of doublecortin‐positive (DCX+) neurons, provides a potential biomarker of stress experience in laying hens.
Lindsay Neuert, Vern Osborne, Elena A. Armstrong, Fábio Pértille, Carlos Guerrero Bosagna, Timothy Boswell, Tom V. Smulders, Christine F. Baes, Bayode O. Makanjuola   +8 more
wiley   +1 more source