Results 121 to 130 of about 27,094 (219)

Insights Into the Role of Lysine Acetylation of Non‐Histone Proteins in Plant Immunity

Plant, Cell &Environment, Volume 49, Issue 10, Page 7604-7618, October 2026.
ABSTRACT Plant immunity is regulated by numerous transcriptional and posttranslational mechanisms. Among these, lysine acetylation, which is controlled by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), has been extensively studied, particularly in the context of epigenetic regulation through histone acetylation.
Jérémy Villette, Chloé Ilbert, Sébastien Aimé, Hoai‐Nam Truong, Marielle Adrian, Stéphane Bourque   +5 more
wiley   +1 more source

Sodium Channel Blockers Demonstrate Binding Affinity for the Tandem Tudor Domain of the Epigenetic Hub UHRF1

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
An investigation of the tandem Tudor domain (TTD) domain of UHRF1 identified and extensively characterized the local anesthetic hydroxyprocaine as a strong ligand capable of activating related genes such as p53 and also highlighted a new, potentially druggable intramolecular interaction between TTD and UBL.
Efstratios Tsakalidis, Mariangela Giannouli, Ifigeneia Akrani, Anthi Panara, Eleni Katalagarianou, Kyriaki Degaita, Maria Giahou, Konstantina Kyriakou, Maria Routsi, Panagiota Efstathia Nikolaou, Evangelia Tsitsou, Aggeliki Tsoka, Constantinos C. Vorgias, Emmanuel Mikros, Evangelos Gikas, Eleni K. Efthimiadou, Vassilios Myrianthopoulos   +16 more
wiley   +1 more source

Fragment-Based Discovery of Low-Micromolar ATAD2 Bromodomain Inhibitors

, 2015
Overexpression of ATAD2 (ATPase family, AAA domain containing 2) has been linked to disease severity and progression in a wide range of cancers, and is implicated in the regulation of several drivers of cancer growth. Little is known of the dependence of
Bhumika V. Karamshi (1562527), Amanda J. Emmons (1562518), Kelly Locke (1562521), Emma J. Jones (1343448), Nathalie Barrett (153158), Robert J. Watson (1503289), Emmanuel H. Demont (1399288), Rebecca C. Furze (1562512), Angela M. Bridges (1562536), Andy D. Roberts (1562530), Peter D. Craggs (1343430), Bernadette H. Mouzon (1562533), Paola Grandi (1343472), Anne-Marie Michon (1343457), Chun-wa Chung (1343454), Darren J. Mitchell (1343451), Robert J. Sheppard (1343445), Paul Bamborough (1343466), Hawa Diallo (1432720), Chris Wellaway (1562515), Rab K. Prinjha (449759), David P. Dixon (1562524), Clement Douault (1432714)   +22 more
core   +1 more source

From Chromatin to Clinic: BET Bromodomain Inhibitors as Novel Disease-modifying Therapies in Heart Failure

Archives of Medicine and Health Sciences
With an emphasis on their methods of action, preclinical data, and clinical development, this study attempts to investigate the potential of BET bromodomain inhibitors as innovative disease-modifying treatments for heart failure.
Omar Elsaka
doaj   +1 more source

Structure-based discovery of selective BRPF1 bromodomain inhibitors

, 2018
Bromodomain and plant homeodomain (PHD) finger containing protein 1 (BRPF1) is a member of subfamily IV of the human bromodomains. Experimental evidence suggests that BRPF1 is involved in leukemia.
Chunxian Zhou, Zhou, Chunxian, Amedeo Caflisch, Zhu, Jian, Jian Zhu, Caflisch, Amedeo   +5 more
core   +1 more source

BRD proteins in human retroviral infection: emerging evidence from HIV-1 and future perspectives for HTLV-1. [PDF]

Mol Biol Rep
Akbarin MM, Farjami Z, Álvarez HR.
europepmc   +1 more source

Bromodomain [PDF]

, 2020
openaire   +1 more source

Structural Genomics Defines PBRM1 Bromodomain Variant Function in ccRCC. [PDF]

Hum Mutat
Bursch KL, Jorge SD, Catlin AE, Nuñez R, LeClaire MD, Licklider J, Urrutia RA, Smith BC.   +7 more
europepmc   +1 more source

Eyes Toward the Clinic: Selective Inhibition and Degradation Approaches to Bromodomain-Containing Proteins. [PDF]

Chembiochem
Scholtz CR, Pomerantz WCK.
europepmc   +1 more source

Butyrate causes loss of specific acetylation by the histone acetyltransferase p300. [PDF]

iScience
Jiang M, Psoma A, Lyu J, Chiariello MG, Modderman R, Bianchi F, Incarnato D, Marrink SJ, Jonkers IH, van den Bogaart G.   +9 more
europepmc   +1 more source