Results 111 to 120 of about 27,094 (219)
, 2018 Bromodomains are chromatin reader modules that recognize acetylated lysine. Different bromodomains exhibit a preference for specific patterns of lysine acetylation marks on core and variant histone proteins, however, the functional relationships that ...
Samuel Carlson +16 more
core +1 more source
Bromodomain: an acetyl-lysine binding domain [PDF]
, 2002 Bromodomains, an extensive family of evolutionarily conserved protein modules originally found in proteins associated with chromatin and in nearly all nuclear histone acetyltransferases, have been recently discovered to function as acetyl-lysine binding ...
Ming-Ming Zhou +3 more
core +1 more source
Cancer Reports, Volume 9, Issue 10, October 2026.ABSTRACT Background Gallbladder cancer (GBC) is a biologically complex malignancy arising from the epithelial lining of the gallbladder, with adenocarcinoma constituting the major histological subtype. Early detection is challenging because of vague clinical manifestations and the organ's deep‐seated anatomical location, resulting in diagnosis at ...
Nisha Manav +4 more
wiley +1 more source
Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.Computational drug discovery integrates molecular docking, molecular dynamics simulations, and translational clinical targeting to identify next‐generation therapeutics that overcome endocrine resistance in ER‐positive breast cancer. Combined with multi‐omics, artificial intelligence, and biomarker‐guided precision oncology, these approaches accelerate
Emmanuel Ifeanyi Obeagu, Yaregal Asres
wiley +1 more source
Advanced ScienceBlood‐brain barrier (BBB) disruption is central to neurodegenerative and cerebrovascular diseases, but its causal role and therapeutic targeting remain challenging.
Chenxiao Li +10 more
doaj +1 more source
Head &Neck, Volume 48, Issue 10, Page 2810-2820, October 2026.ABSTRACT Introduction Sinonasal cancers are rare and heterogeneous and pose a therapeutic challenge at an advanced stage due to the lack of data on appropriate systemic management. Methods This retrospective multicenter study analyzed 83 patients with recurrent or metastatic sinonasal carcinomas ineligible for curative treatment, treated in France ...
Marie Degrange +16 more
wiley +1 more source
Global chemoproteomic profiling of bromodomain inhibitors
Bromodomain-containing proteins (BCPs) are epigenetic readers that regulate gene expression and play key roles in many diseases including cancer, making them prime targets for drug discovery. While several high-quality chemical probes and inhibitors have
Bauer, Ludwig Gerhard
core +1 more source
Non-canonical reader modules of BAZ1A promote recovery from DNA damage
Nature Communications, 2017 ISWI chromatin remodelers regulate DNA accessibility and have been implicated in DNA damage repair. Here, the authors uncover functions, in response to DNA damage, for the bromodomain of the ISWI subunit BAZ1B and for the non-canonical PHD and ...
Mariano Oppikofer +10 more
doaj +1 more source
Clinical Epigenomics in Rare Diseases: Interpreting DNA Methylation Episignatures
Molecular Genetics &Genomic Medicine, Volume 14, Issue 10, October 2026.Clinical epigenomics extends rare‐disease diagnostics beyond DNA sequence by revealing the downstream regulatory consequences of genetic variation. DNA methylation episignatures provide functional evidence that can support diagnosis, refine variant interpretation, distinguish overlapping disorders, and complement genomic, and multi‐omic testing ...
Himanshu Goel, Shuxiang Goh, Luke Stuart
wiley +1 more source
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 10, Page 1644-1657, October 2026.ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo +5 more
wiley +1 more source