Results 41 to 50 of about 228,641 (336)

The propionate-GPR41 axis in infancy protects from subsequent bronchial asthma onset

Gut Microbes, 2023
Evidence has accumulated that gut microbiota and its metabolites, in particular the short-chain fatty acid propionate, are significant contributors to the pathogenesis of a variety of diseases.
Takashi Ito, Yumiko Nakanishi, Ryohei Shibata, Noriko Sato, Toshi Jinnohara, Sayo Suzuki, Wataru Suda, Masahira Hattori, Ikuo Kimura, Taiji Nakano, Fumiya Yamaide, Naoki Shimojo, Hiroshi Ohno   +12 more
doaj   +1 more source

Mechanisms altering airway smooth muscle cell Ca(2+) homeostasis in two asthma models [PDF]

, 2008
Background: Asthma is characterized by airway remodeling, altered mucus production and airway smooth muscle cell (ASMC) contraction causing extensive airway narrowing. In particular, alterations of ASMC contractility seem to be of crucial importance. The
Bergner, Albrecht, Edelmann, Martin, Fischer, Rainald, Huber, Rudolf M., Kellner, Julia, Oelmez, Hamza, Tantzscher, Juliane   +6 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Development and validation of a nomogram to predict atelectasis in adult lymph node fistula tracheobronchial tuberculosis patients

Frontiers in Medicine
BackgroundLymph node fistula tracheobronchial tuberculosis (TBTB) is a severe respiratory condition that can result in complications such as airway stenosis and atelectasis, posing significant clinical challenges, particularly in adults.
Quhua Yin, Guojian Ou, Yi Zhou, Xiaojian Wen, Heping Huang, Jie Ling, Li Luo   +6 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Obesity and Asthma: Adiponectin Receptor 1 (Adipo R1) and Adiponectin Receptor 2 (Adipo R2) are expressed by normal human bronchial epithelial (NHBE) cells at air-liquid interface (ALI) and expression changes with IL-13 stimulation [PDF]

, 2016
Obesity is recognized as an important risk factor for the development of many chronic diseases such as hypertension, Type 2 diabetes mellitus (T2DM) cardiovascular disease, cancer, renal disease, neurologic dysfunction, metabolic syndrome and asthma (3 ...
Bradley, Jennifer L
core   +1 more source

Manifesto on small airway involvement and management in asthma and chronic obstructive pulmonary disease: an Interasma (Global Asthma Association - GAA) and World Allergy Organization (WAO) document endorsed by Allergic Rhinitis and its Impact on Asthma (ARIA) and Global Allergy and Asthma European Network (GA2LEN) [PDF]

, 2016
Evidence that enables us to identify, assess, and access the small airways in asthma and chronic obstructive pulmonary disease (COPD) has led INTERASMA (Global Asthma Association) and WAO to take a position on the role of the small airways in these ...
A. Cruz, A. Fink-Wagner, A. Yanez, A. Yorgancioglu, ARIA, C. Baez Loyola, C. Nunes, D. Deleanu, D. Ryan, E. Hossny, F. Braido, F. Lavorini, F. Levi-Schaffer, for Interasma Executive Board, G. Passalacqua, G. Rodrigo, G. Walter Canonica, GA2LEN, H. Saito, I. J. Ansotegui, J. A. Ortega-Martell, J. Berstein, J. Bousquet, J. C. Ivancevich, J. Celedon, K. Dobashi, K. Ohta, L. Caraballo, L. Dubuske, L. J. Rosenwasser, L. P. Boulet, L. Zhang, M. Akdis, M. Ebisawa, M. Sanchez-Borges, M. Tang, M. Zernotti, N. Scichilone, O. S. Usmani, P. Greenberger, P. Vichyanond, R. Mosges, R. Pawankar, S. Benjaponpitak, S. Bonini, S. Fineman, S. N. Gonzalez-Diaz, S. Nakajima, T. Slavyanskaya, T. Zuberbier, W. Burks, Z. Awad El-Sayed   +51 more
core   +14 more sources

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

Tissue Tropism in Host Transcriptional Response to Members of the Bovine Respiratory Disease Complex. [PDF]

, 2017
Bovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens.
Behura, Susanta K, Gershwin, Laurel J, Grupioni, Natalia V, Kim, JaeWoo, Neibergs, Holly L, Regitano, Luciana CA, Schnabel, Robert D, Seabury, Christopher M, Taylor, Jeremy F, Tizioto, Polyana C, Toaff-Rosenstein, Rachel, Van Eenennaam, Alison L   +11 more
core   +3 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source