Integrating GPCR Regulation and Calcium Dynamics in Airway Smooth Muscle Function: A Comprehensive Review [PDF]
CellsAsthma is a heterogeneous disease that varies in clinical presentation, severity, and underlying biology but consistently involves airway remodeling (AR) and airway hyperresponsiveness (AHR), which is characterized by excessive airway narrowing in ...
Saptarshi Roy +4 more
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Vagus nerve stimulation as a potential treatment for acute asthmatic bronchoconstriction: a systematic review [PDF]
Frontiers in PhysiologyObjectiveVagus nerve stimulation (VNS) is a therapeutic option for diseases such as epilepsy and depression. Given that the smooth muscle of the bronchi is innervated by the vagus nerve, VNS could aid in treating pathologies of the respiratory system ...
Elizabeth Di Flumeri +8 more
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Allergology International, 2020 Background: Cough variant asthma (CVA) is recognized as a precursor of bronchial asthma (BA). However, the cough response to bronchoconstriction differs between these similar diseases.
Kenta Yamamura +2 more
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Amitriptyline inhibits bronchoconstriction independent of direct receptor binding and reduces number of caveolae [PDF]
Scientific ReportsBronchial asthma is a chronic inflammatory disease with rising prevalence worldwide. Apart from the immunological role of the tricyclic antidepressant amitriptyline in bronchial asthma, there is emerging evidence that inhaled amitriptyline directly ...
Virag Klein +6 more
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Hic-5 drives epithelial mechanotransduction promoting a feed-forward cycle of bronchoconstriction [PDF]
Nature CommunicationsMechanical forces are essential for organ function, but excessive or dysregulated forces can promote pathologic conditions. In asthma, bronchoconstriction narrows the airway, compressing the airway epithelium and activating mechanotransduction, yet key ...
Chimwemwe Mwase +10 more
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Circulating Antimicrobial Peptides as Biomarkers of Inflammation and Airway Dysfunction After Marathon Running [PDF]
BiologyMarathon running exerts physical stress and may lead to transient immune dysregulation, increasing susceptibility to airway inflammation and exercise-induced bronchoconstriction (EIB).
Marie-Therese Lingitz +8 more
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Bronchoconstriction: a potential missing link in airway remodelling [PDF]
Open Biology, 2020 In asthma, progressive structural changes of the airway wall are collectively termed airway remodelling. Despite its deleterious effect on lung function, airway remodelling is incompletely understood.
Michael J. O'Sullivan +2 more
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Separations, 2023 Cinnamon is one of the most commonly used spices worldwide. In some Arab countries, cinnamon is used with other ingredients to relieve bronchospasm and treatment of airways-related disorders.
Najeeb Ur Rehman +7 more
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Excipients of inhaled medications with potential to cause adverse reactions [PDF]
Hospital Pharmacology, 2021 Introduction: In addition to the active pharmaceutical ingredient (API), the composition of the medicines also includes excipients which are only ideally completely pharmacologically inactive. It has been shown that excipients in inhaled preparations can
Kusonić Dejan Ž. +7 more
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Bronchoconstriction following instillation of phenylephrine eye drops in premature infants with bronchopulmonary dysplasia: two cases report [PDF]
Korean Journal of Anesthesiology, 2015 Premature infants requiring an ophthalmic examination or even surgery for retinopathy of prematurity (ROP) have a high prevalence of co-existing bronchopulmonary dysplasia (BPD). Reactive airway is one of the clinical presentations of BPD.
Hyun Jee Kim +2 more
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