Results 1 to 10 of about 16,242 (147)

Vagus nerve stimulation as a potential treatment for acute asthmatic bronchoconstriction: a systematic review [PDF]

Frontiers in Physiology
ObjectiveVagus nerve stimulation (VNS) is a therapeutic option for diseases such as epilepsy and depression. Given that the smooth muscle of the bronchi is innervated by the vagus nerve, VNS could aid in treating pathologies of the respiratory system ...
Elizabeth Di Flumeri, Francine M. Ducharme, Joël St-Pierre, Farbod Niazi, Nathan A. Shlobin, Simon Couillard, Jean-Paul Praud, Alexander G. Weil, Christian Iorio-Morin   +8 more
doaj   +2 more sources

Integrating GPCR Regulation and Calcium Dynamics in Airway Smooth Muscle Function: A Comprehensive Review [PDF]

Cells
Asthma is a heterogeneous disease that varies in clinical presentation, severity, and underlying biology but consistently involves airway remodeling (AR) and airway hyperresponsiveness (AHR), which is characterized by excessive airway narrowing in ...
Saptarshi Roy, Vijaya Kumar Gangipangi, Pravesh Sharma, Rebecca E. Hancock, Pawan Sharma   +4 more
doaj   +2 more sources

Amitriptyline inhibits bronchoconstriction independent of direct receptor binding and reduces number of caveolae [PDF]

Scientific Reports
Bronchial asthma is a chronic inflammatory disease with rising prevalence worldwide. Apart from the immunological role of the tricyclic antidepressant amitriptyline in bronchial asthma, there is emerging evidence that inhaled amitriptyline directly ...
Virag Klein, Anna Michely, Paulina Hempel, Istvan Katona, Klaus Tenbrock, Christian Martin, Eva Verjans   +6 more
doaj   +2 more sources

Hic-5 drives epithelial mechanotransduction promoting a feed-forward cycle of bronchoconstriction [PDF]

Nature Communications
Mechanical forces are essential for organ function, but excessive or dysregulated forces can promote pathologic conditions. In asthma, bronchoconstriction narrows the airway, compressing the airway epithelium and activating mechanotransduction, yet key ...
Chimwemwe Mwase, Wenjiang Deng, Hyo Jin Kim, Jennifer A. Mitchel, Thien-Khoi Phung, Michael J. O’Sullivan, Joel A. Mathews, Jeffrey Crosby, Christopher E. Turner, Adam L. Haber, Jin-Ah Park   +10 more
doaj   +2 more sources

Exercise-Induced Bronchoconstriction

Nursing
Abstract: Exercise-induced bronchospasm (EIB) is a problem encountered by many people, and although it can be controlled, it is often overlooked or attributed to deconditioning. Children and elite athletes tend to have an increased incidence of EIB, but this condition is also encountered in others.
Goldin J, Bruner PJ.
europepmc   +5 more sources

Nanoparticles-Mediated Modulation of TRP Channels: Advances and Therapeutic Potential. [PDF]

Wiley Interdiscip Rev Nanomed Nanobiotechnol
Nanoparticle‐mediated modulation of TRP channels, highlighting the interplay between external stimuli, tailored nanomaterials, and TRP channel activation across a range of physiological contexts. This review examines the roles of TRP channels in cellular signaling and disease, providing insights into how advances in nanotechnology can facilitate ...
Foster KA, Midler N, Shine O, Rosenfeld D.   +3 more
europepmc   +2 more sources

Circulating Antimicrobial Peptides as Biomarkers of Inflammation and Airway Dysfunction After Marathon Running [PDF]

Biology
Marathon running exerts physical stress and may lead to transient immune dysregulation, increasing susceptibility to airway inflammation and exercise-induced bronchoconstriction (EIB).
Marie-Therese Lingitz, Hannes Kühtreiber, Lisa Auer, Michael Mildner, Claus G. Krenn, Clemens Aigner, Bernhard Moser, Christine Bekos, Hendrik Jan Ankersmit   +8 more
doaj   +2 more sources

Management of Exercise-Induced Bronchoconstriction [PDF]

Canadian Respiratory Journal, 1999
Exercise-induced bronchoconstriction (EIB) is a common clinical manifestation of asthma, occurring in 70% to 80% of asthmatics. Evidence suggests that exercise and the ensuing bronchoconstriction do not contribute to a worsening of asthmatic inflammation.
Mark D Inman
doaj   +3 more sources

Impact of cold air exposure on respiratory physiology during light-to-moderate physical activity in healthy adults. [PDF]

Physiol Rep
Abstract Working in cold environments presents unique physiological challenges, and this study sought to investigate the specific impacts of cold air exposure on ventilation during light‐to‐moderate physical activity simulating occupational work demands.
Chapman CL, Potter AW, Schafer EA, Friedl KE, Pryor JL, Looney DP.   +5 more
europepmc   +2 more sources

Mechanisms Involved in the Stimulatory and Inhibitory Effects of 5-Hydroxytryptamine on Vagal Mechanosensitive Afferents in Rat Lung

Frontiers in Physiology, 2022
Mechanosensitive vagal afferents in the lung, rapidly and slowly adapting receptors (RARs and SARs, respectively), play an important role in eliciting the reflexes that regulate the normal airway function.
You Shuei Lin, You Shuei Lin, Chun-Chun Hsu, Chun-Chun Hsu, Ting Ruan, Lu-Yuan Lee   +5 more
doaj   +1 more source