Results 1 to 10 of about 46,102 (235)

A proposal to account for the stimulus, the mechanism, and the mediators released in exercise-induced bronchoconstriction [PDF]

Frontiers in Allergy, 2023
Exercise induced bronchoconstriction (EIB) describes the transient narrowing of the airways that follows vigorous exercise. It commonly occurs in children and adults who have asthma and in elite athletes.
Sandra D. Anderson, Pascale Kippelen
doaj   +2 more sources

Amitriptyline inhibits bronchoconstriction independent of direct receptor binding and reduces number of caveolae [PDF]

Scientific Reports
Bronchial asthma is a chronic inflammatory disease with rising prevalence worldwide. Apart from the immunological role of the tricyclic antidepressant amitriptyline in bronchial asthma, there is emerging evidence that inhaled amitriptyline directly ...
Virag Klein, Anna Michely, Paulina Hempel, Istvan Katona, Klaus Tenbrock, Christian Martin, Eva Verjans   +6 more
doaj   +2 more sources

Vagus nerve stimulation as a potential treatment for acute asthmatic bronchoconstriction: a systematic review [PDF]

Frontiers in Physiology
ObjectiveVagus nerve stimulation (VNS) is a therapeutic option for diseases such as epilepsy and depression. Given that the smooth muscle of the bronchi is innervated by the vagus nerve, VNS could aid in treating pathologies of the respiratory system ...
Elizabeth Di Flumeri, Francine M. Ducharme, Joël St-Pierre, Farbod Niazi, Nathan A. Shlobin, Simon Couillard, Jean-Paul Praud, Alexander G. Weil, Christian Iorio-Morin   +8 more
doaj   +2 more sources

Aeroacoustic sound alteration in airway bronchoconstriction, represented by a constricted T-branch model

Journal of Biomechanical Science and Engineering, 2015
Lung sound is commonly analyzed when testing for lung abnormalities. However, the accuracy of this analysis is low and more information on sound generation and alteration is needed to improve the analysis quality.
Gabriel Pramudita SAPUTRA, Kazunori NOZAKI, Satoshi II, Shigeo WADA   +3 more
doaj   +3 more sources

Circulating Antimicrobial Peptides as Biomarkers of Inflammation and Airway Dysfunction After Marathon Running [PDF]

Biology
Marathon running exerts physical stress and may lead to transient immune dysregulation, increasing susceptibility to airway inflammation and exercise-induced bronchoconstriction (EIB).
Marie-Therese Lingitz, Hannes Kühtreiber, Lisa Auer, Michael Mildner, Claus G. Krenn, Clemens Aigner, Bernhard Moser, Christine Bekos, Hendrik Jan Ankersmit   +8 more
doaj   +2 more sources

Deep inspiration and the emergence of ventilation defects during bronchoconstriction: a computational study. [PDF]

PLoS ONE, 2014
Deep inspirations (DIs) have a dilatory effect on airway smooth muscle (ASM) that helps to prevent or reduce more severe bronchoconstriction in healthy individuals. However, this bronchodilation appears to fail in some asthmatic patients or under certain
Amir H Golnabi, R Scott Harris, Jose G Venegas, Tilo Winkler   +3 more
doaj   +5 more sources

Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse [PDF]

Respiratory Research, 2006
Background It has been proposed that serotonin (5-HT)-mediated constriction of the murine trachea is largely dependent on acetylcholine (ACh) released from the epithelium.
Koepsell Hermann, Wess Jürgen, Schinkel Alfred H, Wessler Ignatz, Akinci Sibel, Wiegand Silke, Kummer Wolfgang, Haberberger Rainer V, Lips Katrin S   +8 more
doaj   +3 more sources

Bronchoconstriction Induces TGF-β Release and Airway Remodelling in Guinea Pig Lung Slices. [PDF]

PLoS ONE, 2013
Airway remodelling, including smooth muscle remodelling, is a primary cause of airflow limitation in asthma. Recent evidence links bronchoconstriction to airway remodelling in asthma. The mechanisms involved are poorly understood.
Tjitske A Oenema, Harm Maarsingh, Marieke Smit, Geny M M Groothuis, Herman Meurs, Reinoud Gosens   +5 more
doaj   +2 more sources

Effects of Muscarinic Receptor Antagonists With or Without M2 Antagonist Activity on Cholinergic Reflex Bronchoconstriction in Ovalbumin-Sensitized and -Challenged Mice

Journal of Pharmacological Sciences, 2003
To investigate whether the inhibition of muscarinic M2 receptors results in the enhancement of reflex bronchoconstriction under airway hyperresponsiveness, we evaluated the effects of muscarinic antagonists with or without M2 antagonist activity on ...
Hiroyasu Hirose, Jian Jiang, Masaru Nishikibe   +2 more
doaj   +2 more sources

Mechanisms Involved in the Stimulatory and Inhibitory Effects of 5-Hydroxytryptamine on Vagal Mechanosensitive Afferents in Rat Lung

Frontiers in Physiology, 2022
Mechanosensitive vagal afferents in the lung, rapidly and slowly adapting receptors (RARs and SARs, respectively), play an important role in eliciting the reflexes that regulate the normal airway function.
You Shuei Lin, You Shuei Lin, Chun-Chun Hsu, Chun-Chun Hsu, Ting Ruan, Lu-Yuan Lee   +5 more
doaj   +1 more source