Vagus nerve stimulation as a potential treatment for acute asthmatic bronchoconstriction: a systematic review [PDF]
Frontiers in PhysiologyObjectiveVagus nerve stimulation (VNS) is a therapeutic option for diseases such as epilepsy and depression. Given that the smooth muscle of the bronchi is innervated by the vagus nerve, VNS could aid in treating pathologies of the respiratory system ...
Elizabeth Di Flumeri +8 more
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Integrating GPCR Regulation and Calcium Dynamics in Airway Smooth Muscle Function: A Comprehensive Review [PDF]
CellsAsthma is a heterogeneous disease that varies in clinical presentation, severity, and underlying biology but consistently involves airway remodeling (AR) and airway hyperresponsiveness (AHR), which is characterized by excessive airway narrowing in ...
Saptarshi Roy +4 more
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Role of acetylcholine and polyspecific cation transporters in serotonin-induced bronchoconstriction in the mouse [PDF]
Respiratory Research, 2006 Background It has been proposed that serotonin (5-HT)-mediated constriction of the murine trachea is largely dependent on acetylcholine (ACh) released from the epithelium.
Koepsell Hermann +8 more
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Amitriptyline inhibits bronchoconstriction independent of direct receptor binding and reduces number of caveolae [PDF]
Scientific ReportsBronchial asthma is a chronic inflammatory disease with rising prevalence worldwide. Apart from the immunological role of the tricyclic antidepressant amitriptyline in bronchial asthma, there is emerging evidence that inhaled amitriptyline directly ...
Virag Klein +6 more
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Hic-5 drives epithelial mechanotransduction promoting a feed-forward cycle of bronchoconstriction [PDF]
Nature CommunicationsMechanical forces are essential for organ function, but excessive or dysregulated forces can promote pathologic conditions. In asthma, bronchoconstriction narrows the airway, compressing the airway epithelium and activating mechanotransduction, yet key ...
Chimwemwe Mwase +10 more
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Deep inspiration and the emergence of ventilation defects during bronchoconstriction: a computational study. [PDF]
PLoS ONE, 2014 Deep inspirations (DIs) have a dilatory effect on airway smooth muscle (ASM) that helps to prevent or reduce more severe bronchoconstriction in healthy individuals. However, this bronchodilation appears to fail in some asthmatic patients or under certain
Amir H Golnabi +3 more
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Exercise-Induced Bronchoconstriction
NursingAbstract: Exercise-induced bronchospasm (EIB) is a problem encountered by many people, and although it can be controlled, it is often overlooked or attributed to deconditioning. Children and elite athletes tend to have an increased incidence of EIB, but this condition is also encountered in others.
Goldin J, Bruner PJ.
europepmc +5 more sources
Management of Exercise-Induced Bronchoconstriction [PDF]
Canadian Respiratory Journal, 1999 Exercise-induced bronchoconstriction (EIB) is a common clinical manifestation of asthma, occurring in 70% to 80% of asthmatics. Evidence suggests that exercise and the ensuing bronchoconstriction do not contribute to a worsening of asthmatic inflammation.
Mark D Inman
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Circulating Antimicrobial Peptides as Biomarkers of Inflammation and Airway Dysfunction After Marathon Running [PDF]
BiologyMarathon running exerts physical stress and may lead to transient immune dysregulation, increasing susceptibility to airway inflammation and exercise-induced bronchoconstriction (EIB).
Marie-Therese Lingitz +8 more
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Bronchoconstriction: a potential missing link in airway remodelling [PDF]
Open Biology, 2020 In asthma, progressive structural changes of the airway wall are collectively termed airway remodelling. Despite its deleterious effect on lung function, airway remodelling is incompletely understood.
Michael J. O'Sullivan +2 more
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