Results 91 to 100 of about 45,639 (293)

The effect of the tachykinin NK2 receptor antagonist MEN11420 (nepadutant) on neurokinin A-induced bronchoconstriction in asthmatics

Therapeutic Advances in Respiratory Disease, 2009
Objective: We previously reported that the nonpeptide tachykinin NK 2 receptor antagonist SR48968 (saredutant) significantly inhibits neurokinin A-induced bronchoconstriction in patients with asthma. MEN11420 (nepadutant) is a bicyclic peptide tachykinin
Venessa Schelfhout, Veerle Van De Velde, Carlo Maggi, Romain Pauwels, Guy Joos   +4 more
doaj   +1 more source

A novel model of IgE-mediated passive pulmonary anaphylaxis in rats. [PDF]

PLoS ONE, 2014
Mast cells are central effector cells in allergic asthma and are augmented in the airways of asthma patients. Attenuating mast cell degranulation and with it the early asthmatic response is an important intervention point to inhibit bronchoconstriction ...
Eva Wex, Eva Thaler, Sylvia Blum, David Lamb   +3 more
doaj   +1 more source

Characterisation of the novel quinoline RCD405: Relaxant effects on cholinergic and histaminergic tone in human bronchi and small airways

British Journal of Pharmacology, Volume 182, Issue 17, Page 4122-4133, September 2025.
Abstract Background and Purpose Increased contractility of human airway smooth muscle (hASM) is a hallmark of asthma and chronic obstructive pulmonary disease (COPD). Developing new classes of bronchodilators has proved to be challenging because of efficacy and safety concerns.
Paola Rogliani, Clive Page, Francesco Facciolo, Mia Lundblad, Luigino Calzetta   +4 more
wiley   +1 more source

How to perform open tracheal suction via an endotracheal tube [PDF]

, 2016
Rationale and key points Tracheal suction involves the removal of pulmonary secretions from the respiratory tract using negative pressure under sterile conditions.
Credland, Nicola
core   +1 more source

Drug‐induced respiratory depression in FDA Adverse Event Reporting System for 20 years

Hong Kong Journal of Emergency Medicine, Volume 32, Issue 4, August 2025.
Abstract Background Drug‐induced respiratory depression (DIRD) is a common and highly prevalent condition in clinical practice, necessitating early prevention and intervention. This study aimed to identify the association between specific medications and DIRD, providing evidence‐based insights for clinical risk assessment and management.
Wenyin Zhou, Xueliang Yi
wiley   +1 more source

Factors Associated with Poor Asthma Control among Sudanese Patients Attending Atbara Teaching Hospital in Sudan

Sudan Journal of Medical Sciences
Objective: To identify factors associated with poor bronchial asthma control in patients attending Atbara Teaching Hospital, Sudan, in 2020. Methods: This was an analytical, descriptive, cross-sectional hospital-based study conducted at the Atbara ...
Hadeel Kareem Aladdin, Sufian Khalid Mohammed Noor, Amro Mohamed Fagir Farah, Sara Elamin Bushara   +3 more
doaj   +1 more source

Verapamil Induces Calcium Influx in the Trachea

Journal of Pharmacological Sciences, 2008
Verapamil, a Ca2+entry blocker, can induce bronchorelaxation and bronchoconstriction. The mechanism of verapamil-induced bronchoconstriction is poorly understood.
Seham Mustafa, Abdulkareem Abdulraheem, Abdulhakeem Alsughayer   +2 more
doaj   +1 more source

Breathing and balance: Clinical insights and management strategies of respiratory acid‐base disorders

Nutrition in Clinical Practice, Volume 40, Issue 4, Page 774-792, August 2025.
Abstract Respiratory acidosis and alkalosis are two of the four main acid‐base processes encountered in clinical practice. These two processes are tightly balanced by breathing. Identification and management of respiratory acid‐base disorders are important for clinicians, particularly when caring for patients with underlying pulmonary and neurological ...
Anne M. Tucker, Tami N. Johnson
wiley   +1 more source

The inhibitory effect of anti-allergic agent suplatast tosilate (IPD–1151T) on methacholine- and allergen-induced bronchoconstriction in sensitized mice

Mediators of Inflammation, 2000
The influence of an anti-allergic agent, suplatast tosilate (IPD-1151T; (±)-[2-[4-(3-ethoxy–2-hydroxypropoxy)phenyl-carbamoyl]-ethyl] dimethylsulfonium p-toluenesulfonate) on allergic bronchoconstriction induced by allergen and methacholine (MCh) were ...
Kazuhito Asano, Tetsuya Mizutani, Toshikazu Shimane, Masataka Hisano, Tadashi Hisamitsu, Harumi Suzaki   +5 more
doaj   +1 more source

Effects of Muscarinic Receptor Antagonists With or Without M2 Antagonist Activity on Cholinergic Reflex Bronchoconstriction in Ovalbumin-Sensitized and -Challenged Mice

Journal of Pharmacological Sciences, 2003
To investigate whether the inhibition of muscarinic M2 receptors results in the enhancement of reflex bronchoconstriction under airway hyperresponsiveness, we evaluated the effects of muscarinic antagonists with or without M2 antagonist activity on ...
Hiroyasu Hirose, Jian Jiang, Masaru Nishikibe   +2 more
doaj   +1 more source