Results 41 to 50 of about 2,957 (143)

Location, Location, Location: Spatial Immune‐Stroma Crosstalk Drives Pathogenesis in Asthma

Immunological Reviews, Volume 330, Issue 1, March 2025.
ABSTRACT Chronic lung diseases including asthma are characterized by an abnormal immune response and active tissue remodeling. These changes in the architecture of the tissue are a fundamental part of the pathology across the life course of patients suffering from asthma.
Régis Joulia, Clare M. Lloyd
wiley   +1 more source

Pulmonary surfactant and prostaglandin E2 in airway smooth muscle relaxation of human and male guinea pigs

Physiological Reports, Volume 12, Issue 17, September 2024.
The relaxant effect of pulmonary surfactant on airway smooth muscle (Prostaglandin E2). Abstract Pulmonary surfactant serves as a barrier to respiratory epithelium but can also regulate airway smooth muscle (ASM) tone. Surfactant (SF) relaxes contracted ASM, similar to β2‐agonists, anticholinergics, nitric oxide, and prostanoids. The exact mechanism of
J. Hanusrichterova, M. Kolomaznik, R. Barosova, J. Adamcakova, D. Mokra, J. Mokry, H. Skovierova, M. M. Kelly, E. de Heuvel, S. Wiehler, D. Proud, H. Shen, P. G. Mukherjee, M. W. Amrein, A. Calkovska   +14 more
wiley   +1 more source

Tachykinin receptors antagonism for asthma: a systematic review [PDF]

, 2011
Background Tachykinins substance P, neurokinin A and neurokinin B seem to account for asthma pathophysiology by mediating neurogenic inflammation and several aspects of lung mechanics.
Renata Ramalho, Raquel Soares, Nuno Couto, André Moreira   +3 more
core   +2 more sources

Direct vagus nerve stimulation: A new tool to control allergic airway inflammation through α7 nicotinic acetylcholine receptor

British Journal of Pharmacology, Volume 181, Issue 13, Page 1916-1934, July 2024.
Abstract Background and Purpose Asthma is characterized by airway inflammation, mucus hypersecretion, and airway hyperresponsiveness. The use of nicotinic agents to mimic the cholinergic anti‐inflammatory pathway (CAP) controls experimental asthma. Yet, the effects of vagus nerve stimulation (VNS)‐induced CAP on allergic inflammation remain unknown ...
Caroline Sévoz‐Couche, Wupeng Liao, Hazel Y. C. Foo, Isabelle Bonne, Thong Beng Lu, Caris Tan Qi Hui, Syaza Hazwany Azhar, Wendy Yen Xian Peh, Shih‐Cheng Yen, W. S. Fred Wong   +9 more
wiley   +1 more source

The human MIF polymorphism CATT7 enhances pro‐inflammatory macrophage polarization in a clinically relevant model of allergic airway inflammation

The FASEB Journal, Volume 38, Issue 6, 31 March 2024.
CATT7 human MIF polymorphism drives M1 macrophage polarization and priming. Bone marrow‐derived macrophages isolated from CATT7 MIF mice challenged with house dust mite in vivo demonstrate enhanced pro‐inflammatory M1 macrophage polarization after LPS/IL‐4 activation. Training naive CATT7 BMDMs in vitro with HDM followed by a rest period and subsequent
Hazel Dunbar, Ian J. Hawthorne, Eóin N. McNamee, Michelle E. Armstrong, Seamas C. Donnelly, Karen English   +5 more
wiley   +1 more source

Regular treatment with salmeterol and inhaled steroids for chronic asthma: serious adverse events [PDF]

, 2009
Epidemiological evidence has suggested a link between beta(2)-agonists and increased asthma mortality. There has been much debate about possible causal links for this association, and whether regular (daily) long-acting beta(2)-agonists are safe ...
Altman, Anonymous, Arthurs, Aubier, Bailey, Barnes, Bateman, Bateman, Bateman, Bateman, Bateman, Bateman, Bateman, Beach, Bons, Boushey, Boushey, Boushey, Bousquet, Bousquet, Bousquet, Briggs, Busse, Busse, Castle, Cates, Cates, Cates Christopher, Clark, Clark, Clark, Clark, Clark, Cordier, Ducharme, Edin, Giembycz, Godard, Greenstone, Ind, Jarjour, Juniper, Kavuru, Koenig, Koopmans, Lipworth, Lundbäck, Malone, Murray, Nathan, Nathan, Nelson, Nelson, Ni Chroinin, Ni Chroinin, Noord, Pauwels, Pauwels, Pauwels, Pearce, Pearlman, Pearlman, Pedersen, Pedersen, Pederson, Rojas, Rooklin, Salpeter, Sears, Shapiro, Strand, Wallin, Walters, Walters, Weinstein   +74 more
core   +1 more source

Use of human airway smooth muscle in vitro and ex vivo to investigate drugs for the treatment of chronic obstructive respiratory disorders

British Journal of Pharmacology, Volume 181, Issue 5, Page 610-639, March 2024.
Abstract Isolated airway smooth muscle has been extensively investigated since 1840 to understand the pharmacology of airway diseases. There has often been poor predictability from murine experiments to drugs evaluated in patients with asthma or chronic obstructive pulmonary disease (COPD).
Luigino Calzetta, Clive Page, Maria Gabriella Matera, Mario Cazzola, Paola Rogliani   +4 more
wiley   +1 more source

Respiratory effects of potent hypotensive derivatives of veratrum. [PDF]

, 1951
Thesis (M.A.)--Boston ...
Mosey, Lois M
core   +1 more source

Environmental tobacco smoke, indoor allergens, and childhood asthma. [PDF]

, 2011
Both environmental tobacco smoke and indoor allergens can exacerbate already established childhood albeit primarily through quite disparate mechanisms.
Gold, Diane R.
core   +1 more source

Evaluation of Yield and Physicochemical Quality of Pentadesma butyracea Butter Obtained by Different Traditional Extraction Methods in Ghana

International Journal of Food Science, Volume 2024, Issue 1, 2024.
Pentadesma butyracea seed butter or fat (PBSB) is a vegetable fat extracted from the seeds of the P. butyracea plant. The butter has potential use in the food, pharmaceutical, and cosmetic industries. The study investigated traditional PBSB processing methods in Ghana and evaluated their effects on yield, physicochemical parameters, and fatty acid ...
Josephine Akuba Timtey, Francis Alemawor, William Otoo Ellis, Jacob K. Agbenorhevi, Nana Baah Pepra-Ameyaw, Severino Matias de Alencar   +5 more
wiley   +1 more source