Results 31 to 40 of about 2,957 (143)

Lipid Metabolism and Obesity in Early Life: Drivers of Chronic Lung Disease From Development to Adulthood

Molecular Nutrition &Food Research, Volume 70, Issue 7, 15 April 2026.
Metabolic and nutritional stressors are a growing global health concern. This review discusses how obesity, lipids, and lipid derivatives influence lung development, homeostasis, and chronic lung disease progression, highlighting roles of alveolar surfactant and sphingolipids.
Jaco Selle, Natascha Mierswa, Leon Saschin, Jana Niehues, Jörg Dötsch, Eva Nüsken, Kai‐Dietrich Nüsken, Julia Schipke, Miguel A. Alejandre Alcazar   +8 more
wiley   +1 more source

A real – life observational pilot study to evaluate the effects of two-week treatment with montelukast in patients with chronic cough [PDF]

, 2014
BACKGROUND: Different conditions make the proximal airways susceptible to tussigenic stimuli in the chronic cough (CC) syndrome. Leukotrienes can be implicated in the inflammatory mechanism at play in it.
Denislava Nedeva, Karina Bacheva, Maria Staevska, Miroslava Rasheva, Penka Perenovska, Roxana K Mincheva, Tanya Z Kralimarkova, Todor A Popov, Vasil D Dimitrov, Vera Papochieva, Zlatko Dimitrov   +10 more
core   +1 more source

Acepromazine Reduces Airway Contraction in a Murine Model of Asthma

Clinical and Experimental Pharmacology and Physiology, Volume 53, Issue 3, March 2026.
ABSTRACT Acepromazine (ACP) is one of the most used sedatives in veterinary medicine, and its cardiovascular effects are well documented. In contrast, its effects on the respiratory system remain less well understood, particularly in the context of assessment of respiratory mechanics in murine models of asthma, where its use has become more common in ...
Alembert Lino‐Alvarado, Maria Aparecida de Oliveira, Carmen Silvia Moreno Serra, Isabella Victoria Santana Melhado, Rafael Campos, Yanira Riffo‐Vasquez, Henrique Takachi Moriya   +6 more
wiley   +1 more source

Airway smooth muscle as an immunomodulatory cell. [PDF]

, 2009
Although pivotal in regulating bronchomotor tone in asthma, airway smooth muscle (ASM) also modulates airway inflammation in asthma. ASM myocytes secrete or express a wide array of immunomodulatory mediators in response to extracellular stimuli, and in ...
Ammit, Ammit, Ammit, Ammit, Amrani, Beck-Schimmer, Belvisi, Berkman, Bonazzi, Bradding, Braun-Fahrlander, Brightling, Brightling, Chan, Christodoulopoulos, Dabbagh, De, DiCosmo, El-Shazly, Elias, Gautam Damera, Gonzalo, Hakonarson, Hakonarson, Hakonarson, Hall, Hallsworth, Hallsworth, Hardaker, Hedges, Hollenberg, Hollins, Howarth, Hughes, Imai, John, Joubert, Kanehiro, Kanehiro, Keslacy, Knight, Kroger, Lajoie-Kadoch, Lazaar, Lazaar, Lazaar, Lazzeri, Lee, Leung, Leung, Li, Lukacs, Luo, Mamane, McKay, Morris, Nakao, Oakley, Oliver, Omar Tliba, Panettieri, Pang, Pang, Pang, Peng, Pujols, Pype, Ramos-Barbon, Reynold A. Panettieri, Riffo-Vasquez, Rodel, Saunders, Sousa, Sukkar, Sukkar, Tang, Tliba, Tliba, Tliba, Tliba, Tliba, Tran, van Seventer, Wang, Wegmann, Wen, Yamada, Yang, Ying   +88 more
core   +2 more sources

Maternal exposure to combustion generated PM inhibits pulmonary Th1 maturation and concomitantly enhances postnatal asthma development in offspring [PDF]

, 2013
BACKGROUND: Epidemiological studies suggest that maternal exposure to environmental hazards, such as particulate matter, is associated with increased incidence of asthma in childhood. We hypothesized that maternal exposure to combustion derived ultrafine
Dahui You, Huahao Shen, Jordy Saravia, Pingli Wang, Stephania A Cormier   +4 more
core   +2 more sources

Evaluation of Total Serum IgE Level and Associated Factors in Asthmatic Patients at the University of Gondar Hospital, Northwest Ethiopia: A Comparative Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 1, January 2026.
ABSTRACT Background and Aims Asthma is a chronic respiratory disorder with both genetic and environmental underlying risk factors. Allergic asthma, the most prevalent kind, is mostly ascribed to aberrant T helper type 2 (Th2) inflammation and is brought on by allergens.
Ayenew Assefa, Tadelo Wondmagegn, Markos Negash   +2 more
wiley   +1 more source

Expanding the Immunologic and Neuronal Landscape of IgE‐Mediated Anaphylaxis

Immunological Reviews, Volume 337, Issue 1, January 2026.
ABSTRACT Anaphylaxis is a life‐threatening immunoglobulin E (IgE)‐mediated type I hypersensitivity reaction with rising prevalence and burden. It involves mast cell degranulation upon cross‐linking of antigen on mast cell‐bound IgE. Mechanisms of IgE‐mediated anaphylaxis remain incompletely understood, particularly the induction of systemic symptoms ...
Ruchi Biswas, Jamie Moore Fried, Maria A. Curotto de Lafaille   +2 more
wiley   +1 more source

Beta-blockers in COPD:time for reappraisal [PDF]

, 2016
The combined effects on the heart of smoking and hypoxaemia may contribute to an increased cardiovascular burden in chronic obstructive pulmonary disease (COPD).
Devereux, Graham, Dransfield, Mark T., Lipworth, Brian, Vestbo, Jørgen, Wedzicha, Jadwiga   +4 more
core   +3 more sources

Effects of the P2RX4 antagonist BR11595 in a guinea pig model of chronic asthma

British Journal of Pharmacology, Volume 182, Issue 21, Page 5378-5390, November 2025.
Abstract Background and Purpose Asthma is characterized by airway hyperresponsiveness (AHR), allergic inflammation, and airway remodelling. Although recent studies have shown that asthma pathophysiology involves P2X4 receptor activation, a potential link with chronic asthma remains to be explored.
Dan Li, Hoeke A. Baarsma, Melissa Mol‐van der Veen, Vicky Verschut, Kimberley S. Belfor, Tanja de Boer, Harm Maarsingh, Oliver Martin Fischer, Carolin Ebert, Hana Cernecka, Muriel Lizé, Reinoud Gosens, Loes Kistemaker, Martina Schmidt   +13 more
wiley   +1 more source

Effects of nebulised magnesium sulphate on inflammation and function of the guinea-pig airway [PDF]

, 2017
Magnesium sulphate is a potential treatment for acute severe asthma. However, the mechanisms and dose-response relationships are poorly understood. The first objective of this study was to examine whether inhaled magnesium sulphate exerts bronchodilator ...
Broadley, Kenneth J., Ford, William R., Kidd, Emma J., Powell, Colin, Turner, Dawn L.   +4 more
core   +2 more sources