Results 11 to 20 of about 2,957 (143)

Coumarins and Their Derivatives in Animal Models of Asthma: A Systematic Review. [PDF]

Basic Clin Pharmacol Toxicol
Mast cells drive early allergic asthma by releasing histamine, interleukins and prostaglandins, causing airway hyperresponsiveness, mucus overproduction and inflammation. These events sustain symptoms and promote structural remodelling, contributing to the progression of the disease.
Dos Santos IM, de Oliveira Rocha JL, de Alencar Filho EB, Silva FS.   +3 more
europepmc   +2 more sources

Potentially Overlooked Risk for Neuropsychiatric Symptoms in Children: Montelukast Treatment. [PDF]

J Paediatr Child Health
ABSTRACT Background Montelukast is a leukotriene receptor antagonist commonly used in allergic diseases. In this study, we investigated the frequency, severity and risk factors for neuropsychiatric side effects and sleep disorders associated with montelukast in children.
Tunca S, Yilmaz O, Ocalan M, Arga M, Cavkaytar O, Ozceker D, Kiliç M, Duksal F, Can D, Sancakli O, Kaya MŞ, Ercan N, Gunaydin NC, Aydogan M, Demir E, Sancak R, Karadag SİK, Sapan N, Demir AU, Bilac O, Misirlioglu ED, Turkeli A, Artac H, Gungor HE, Cokugras H, Orhan F, Bingol A, Uysal P, Keles S, Ozhan AK, Tuncel T, Keskin O, Arik E, Özdemir Ö, Can C, Altinel N, Harmanci K, Simsek Y, Altintas DU, Ozmen S, Uzuner N, Canıtez Y, Yüksel H.   +42 more
europepmc   +2 more sources

Evaluation of the reproducibility of responses to nasal allergen challenge and effects of inhaled nasal corticosteroids

Clinical &Experimental Allergy, Volume 53, Issue 11, Page 1187-1197, November 2023., 2023
Nasal allergen challenge induces reproducible nasal symptoms and biomarkers reflecting early and late phase allergy responses and, depending on the endpoint, is suitable for assessing pharmacodynamic activity and proof of mechanism for drugs targeting allergic inflammation.
Rebecca N. Bauer, Yanqing Xie, Suzanne Beaudin, Lesley Wiltshire, Jennifer Wattie, Caroline Muñoz, Nadia Alsaji, John Paul Oliveria, Xiaotian Ju, Jonathan MacLean, Doron D. Sommer, Paul K. Keith, Imran Satia, Ruth P. Cusack, Paul M. O'Byrne, Gizette Sperinde, Martha Hokom, Olga Li, Prajna Banerjee, Chen Chen, Tracy Staton, Roma Sehmi, Gail M. Gauvreau   +22 more
wiley   +1 more source

The Multifarious Functions of Leukotrienes in Bone Metabolism

Journal of Bone and Mineral Research, Volume 38, Issue 8, Page 1135-1153, August 2023., 2023
Bone profile of 5‐LO–deficient mouse model. We investigated the effects of leukotrienes on bone metabolism using a 5‐LO KO mouse model. Long bones phenotype of females and males lacking 5‐LO present thicker cortical bone and increased marrow area but decreased trabecular bone only in females.
Flávia Amadeu de Oliveira, Cintia K. Tokuhara, Vimal Veeriah, João Paulo Domezi, Mariana R. Santesso, Tania M. Cestari, Talita M.O. Ventura, Adriana A. Matos, Thiago Dionísio, Marcel R. Ferreira, Rafael C. Ortiz, Marco A.H. Duarte, Marília A.R. Buzalaf, José B. Ponce, Carlos A. Sorgi, Lucia H. Faccioli, Camila Peres Buzalaf, Rodrigo Cardoso de Oliveira   +17 more
wiley   +1 more source

Blockade of MIF biological activity ameliorates house dust mite‐induced allergic airway inflammation in humanized MIF mice

The FASEB Journal, Volume 37, Issue 8, August 2023., 2023
CATT7 and WT mice received HDM challenge, which enters through the damaged epithelium resulting in an increase in goblet cell hyperplasia, airway remodeling, eosinophilia, cellular infiltration, Th2 cytokine production, and airway resistance. High human MIF expressing CATT7 mice present a more severe phenotype compared to WT mice.
Hazel Dunbar, Ian J. Hawthorne, Courteney Tunstead, Michelle E. Armstrong, Seamas C. Donnelly, Karen English   +5 more
wiley   +1 more source

Asthma‐inducing potential of 28 substances in spray cleaning products—Assessed by quantitative structure activity relationship (QSAR) testing and literature review

Journal of Applied Toxicology, Volume 42, Issue 1, Page 130-153, January 2022., 2022
Abstract Exposure to spray cleaning products constitutes a potential risk for asthma induction. We set out to review whether substances in such products are potential inducers of asthma. We identified 101 spray cleaning products for professional use. Twenty‐eight of their chemical substances were selected.
Niels Hadrup, Marie Frederiksen, Eva B. Wedebye, Nikolai G. Nikolov, Tanja K. Carøe, Jorid B. Sørli, Karen B. Frydendall, Biase Liguori, Camilla S. Sejbaek, Peder Wolkoff, Esben M. Flachs, Vivi Schlünssen, Harald W. Meyer, Per A. Clausen, Karin S. Hougaard   +14 more
wiley   +1 more source

Uncovering the Role of Oxidative Imbalance in the Development and Progression of Bronchial Asthma

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
Asthma is a chronic inflammatory disease of the airways related to epithelial damage, bronchial hyperresponsiveness to contractile agents, tissue remodeling, and luminal narrowing. Currently, there are many data about the pathophysiology of asthma; however, a new aspect has emerged related to the influence of reactive oxygen and nitrogen species (ROS ...
Luiz H. C. Vasconcelos, Sarah R. D. Ferreira, Maria da C. C. Silva, Paula B. Ferreira, Iara L. L. de Souza, Fabiana de A. Cavalcante, Bagnólia A. da Silva, vincent Lagente   +7 more
wiley   +1 more source

Th2 cytokines and asthma The role of interleukin-5 in allergic eosinophilic disease [PDF]

, 2001
Interleukin-5 is produced by a number of cell types, and is responsible for the maturation and release of eosinophils in the bone marrow. In humans, interleukin-5 is a very selective cytokine as a result of the restricted expression of the interleukin-5 ...
Chapman Richard W, Cuss Francis M, Umland Shelby P, Greenfeder Scott, Egan Robert W   +4 more
core   +2 more sources

Cysteinyl Leukotriene Receptor-1 Antagonists as Modulators of Innate Immune Cell Function

Journal of Immunology Research, 2014
Cysteinyl leukotrienes (cysLTs) are produced predominantly by cells of the innate immune system, especially basophils, eosinophils, mast cells, and monocytes/macrophages. Notwithstanding potent bronchoconstrictor activity, cysLTs are also proinflammatory
A. J. Theron, H. C. Steel, G. R. Tintinger, C. M. Gravett, R. Anderson, C. Feldman   +5 more
doaj   +1 more source

Ipratropium/Salbutamol Comparator Versus Originator for Chronic Obstructive Pulmonary Disease Exacerbations : USA Observational Cohort Study Using the Clinformatics™ Health Claims Database [PDF]

, 2017
Acknowledgements The authors wish to thank Priyanka Raju Konduru of Observational and Pragmatic Research Institute Pte Ltd (OPRI) for assistance with data extraction.
Gefen, Eran, Gopalan, Gokul, Mares, Rafael, McDonald, Rosie, Ming, Simon Wan Yau, Price, David B., Thomas, Vicky   +6 more
core   +3 more sources