Lipopolysaccharide does not alter small airway reactivity in mouse lung slices [PDF]
, 2015 The bacterial endotoxin, lipopolysaccharide (LPS) has been associated with occupational airway diseases with asthma-like symptoms and in acute exacerbations of COPD.
A Boonstra +35 more
core +3 more sources
A Novel A1 Adenosine Receptor Antagonist, L-97-1 [3-[2-(4-Aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], Reduces Allergic Responses to House Dust Mite in an Allergic Rabbit Model of Asthma [PDF]
, 2005 Adenosine, an important signaling molecule in asthma, produces bronchoconstriction in asthmatics. Adenosine produces bronchoconstriction in allergic rabbits, primates, and humans by activating A1 adenosine receptors (ARs).
Batra, V. K. +5 more
core +1 more source
Airway smooth muscle as a target of asthma therapy: history and new directions [PDF]
, 2006 Ultimately, asthma is a disease characterized by constriction of airway smooth muscle (ASM). The earliest approach to the treatment of asthma comprised the use of xanthines and anti-cholinergics with the later introduction of anti-histamines and anti ...
AL Fuhlbrigge +117 more
core +2 more sources
Regular treatment with formoterol and inhaled steroids for chronic asthma: serious adverse events (Review) [PDF]
, 2009 Background Epidemiological evidence has suggested a link between beta2-agonists and increases in asthma mortality. There has been much debate about possible causal links for this association, and whether regular (daily) long-acting beta2-agonists are ...
Cates, CJ, Jaeschke, R, Lasserson, TJ
core +1 more source
Aspirin‐exacerbated respiratory disease: A review
Laryngoscope Investigative Otolaryngology, Volume 5, Issue 3, Page 360-367, June 2020., 2020 Abstract Objectives Aspirin‐exacerbated respiratory disease (AERD) is a chronic respiratory condition characterized by a triad of symptoms: asthma, chronic rhinosinusitis with nasal polyposis, and a respiratory reaction to aspirin and other cyclooxygenase‐1 inhibitors, also known as nonsteroidal anti‐inflammatory drugs.
Christine Dominas +4 more
wiley +1 more source
Cysteinyl Leukotrienes and Their Receptors; Emerging Concepts [PDF]
, 2014 Cysteinyl leukotrienes (cys-LTs) are potent mediators of inflammation derived from arachidonic acid through the 5-lipoxygenase/leukotriene C4 synthase pathway.
Boyce, Joshua A., Kanaoka, Yoshihide
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Regular treatment with formoterol for chronic asthma: serious adverse events [PDF]
, 2012 Epidemiological evidence has suggested a link between beta(2)-agonists and increases in asthma mortality. There has been much debate about possible causal links for this association, and whether regular (daily) long-acting beta2-agonists are safe ...
Altman +17 more
core +1 more source
Airway Hyperresponsiveness to Mannitol in Obesity Before and After Bariatric Surgery [PDF]
, 2015 The relationship between airway hyperresponsiveness (AHR) and obesity, a low-grade systemic inflammatory condition, remains largely unknown. It is established that AHR to indirect stimuli is associated with active airway inflammation. The objectives were
Ebymar Arismendi +6 more
core +1 more source
A standard, single dose of inhaled terbutaline attenuates hyperpnoea-induced bronchoconstriction and mast cell activation in athletes [PDF]
, 2016 Release of broncho-active mediators from mast cells during exercise hyperpnoea is a key factor in the pathophysiology of exercise-induced bronchoconstriction (EIB).
A. J. Simpson +16 more
core +2 more sources
Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation. [PDF]
, 1994 Eosinophil accumulation is a prominent feature of allergic inflammatory reactions, such as those occurring in the lung of the allergic asthmatic, but the endogenous chemoattractants involved have not been identified.
Collins, PD +8 more
core +1 more source