Results 91 to 100 of about 79,138 (287)

Extrafine beclomethasone/formoterol in severe COPD patients with history of exacerbations [PDF]

, 2014
The FORWARD study is a randomised, double-blind trial that compares the efficacy and safety of 48 weeks treatment with extrafine beclomethasone dipropionate/formoterol fumarate (BDP/FOR), 100/6 μg pMDI, 2 inhalations BID, vs. FOR 12 μg pMDI, 1 inhalation
Agusti, A, Bonnet-Gonod, F, Cohuet, G, Corradi, M, Jones, PW, Paggiaro, PL, Petruzzelli, S, Singh, D, Vestbo, J, Vezzoli, S, Wedzicha, JA   +10 more
core   +1 more source

A genome-wide association study of bronchodilator response in asthmatics

The Pharmacogenomics Journal, 2013
Reversibility of airway obstruction in response to β2-agonists is highly variable among asthmatics, which is partially attributed to genetic factors. In a genome-wide association study of acute bronchodilator response (BDR) to inhaled albuterol, 534 290 ...
Q. Duan, J. Lasky-Su, B. Himes, W. Qiu, A. Litonjua, A. Damask, R. Lazarus, B. Klanderman, C. Irvin, S. Peters, J. Hanrahan, J. Lima, F. Martinez, D. Mauger, V. Chinchilli, M. Soto-Quiros, L. Avila, J. Celedón, C. Lange, S. Weiss, K. Tantisira   +20 more
semanticscholar   +1 more source

Acute bronchitis: challenges of diagnosis and treatment

Медицинский совет, 2013
Internal medicine specialists often have difficulty in making diagnosis and defining the type of treatment for patients with first time long-lasting cough or newly developed bronchial obstruction syndrome. Acute bronchitis (AB) is one of reasons of cough
I. V. Leschenko
doaj   +1 more source

Regional lung deflation with increased airway volume underlies the functional response to bronchodilators in chronic obstructive pulmonary disease

Physiological Reports, 2019
Bronchodilators, including long‐acting muscarinic antagonists (LAMAs), improve airflow limitation and lung hyperinflation in patients with chronic obstructive pulmonary disease (COPD).
Naoya Tanabe, Susumu Sato, Shigeo Muro, Hiroshi Shima, Tsuyoshi Oguma, Kazuya Tanimura, Atsuyasu Sato, Toyohiro Hirai   +7 more
doaj   +1 more source

Beta(2)-adrenergic receptor (ADRB2) gene polymorphisms and risk of COPD exacerbations : the Rotterdam study [PDF]

, 2019
The role of the beta(2)-adrenergic receptor (ADRB2) gene in patients with chronic obstructive pulmonary disease (COPD) is unclear. We investigated the association between ADRB2 variants and the risk of exacerbations in COPD patients treated with inhaled ...
Brusselle, Guy, Ghanbari, Mohsen, Karimi, Leila, Lahousse, Lies, Stricker, Bruno H., Terzikhan, Natalie, Uitterlinden, Andre G., van der Lei, Johan, Verhamme, Katia   +8 more
core   +2 more sources

Bronchodilator responsiveness as a phenotypic characteristic of established chronic obstructive pulmonary disease

Thorax, 2012
Background Bronchodilator responsiveness is a potential phenotypic characteristic of chronic obstructive pulmonary disease (COPD). We studied whether change in lung function after a bronchodilator is abnormal in COPD, whether stable responder subgroups ...
P. Albert, A. Agustí, L. Edwards, R. Tal-Singer, J. Yates, P. Bakke, B. Celli, H. Coxson, C. Crim, D. Lomas, W. Macnee, B. Miller, S. Rennard, E. Silverman, J. Vestbo, E. Wouters, P. Calverley   +16 more
semanticscholar   +1 more source

Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Improves Lung Function versus Monotherapies in GOLD Category A Patients with COPD: Pooled Data from the Phase III PINNACLE Studies

International Journal of COPD, 2020
Fernando J Martinez,1 Klaus F Rabe,2 Brian J Lipworth,3 Samir Arora,4 Martin Jenkins,5 Ubaldo J Martin,6 Colin Reisner6,7 1Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA; 2Department of Pneumonology ...
Martinez FJ, Rabe KF, Lipworth BJ, Arora S, Jenkins M, Martin UJ, Reisner C   +6 more
doaj  

The 24-h lung-function profile of once-daily tiotropium and olodaterol fixed-dose combination in chronic obstructive pulmonary disease [PDF]

, 2015
Background: This study investigated the effects on 24-h lung function and lung volume of a once-daily fixed-dose combination (FDC) of the long-acting muscarinic antagonist tiotropium and the long-acting beta(2)-agonist olodaterol in patients with chronic
Beeh, Kai-Michael, Derom, Eric, Grönke, Lars, Hamilton, Alan, Hébert, Jacques, Kirsten, Anne-Marie, Tetzlaff, Kay, Westerman, Jan   +7 more
core   +2 more sources

A new class of bronchodilator improves lung function in COPD: a trial with GSK961081

European Respiratory Journal, 2013
GSK961081 is a bifunctional molecule demonstrating both muscarinic antagonist and &bgr;-agonist activities. This was a 4-week, multicentre, randomised, double-blind, double-dummy, placebo and salmeterol controlled parallel group study.
P. Wielders, A. Ludwig-Sengpiel, N. Locantore, S. Baggen, R. Chan, J. Riley   +5 more
semanticscholar   +1 more source

Randomized dose-finding study of batefenterol via dry powder inhaler in patients with COPD

International Journal of COPD, 2019
Courtney Crim,1 Michael L Watkins,1 Eric D Bateman,2 Gregory J Feldman,3 Isabelle Schenkenberger,4 Edward M Kerwin,5 Catriona Crawford,6 Krishna Pudi,7 Shuyen Ho,8 Charlotte Baidoo,9 Ramiro Castro-Santamaria10 1GSK, Research and Development, Research ...
Crim C, Watkins ML, Bateman ED, Feldman GJ, Schenkenberger I, Kerwin EM, Crawford C, Pudi K, Ho S, Baidoo C, Castro-Santamaria R   +10 more
doaj