Results 81 to 90 of about 68,751 (311)

A GENOME-WIDE ASSOCIATION STUDY OF BRONCHODILATOR RESPONSE IN LATINOS IMPLICATES RARE VARIANTS

Journal of Allergy and Clinical Immunology, 2013
Rationale The primary rescue medication to treat acute asthma exacerbation is short-acting β2- adrenergic receptor (β2AR) agonists (SABAs), however there is variation in how well an individual responds to treatment.
Katherine A. Drake, D. Torgerson, Christopher R. Gignoux, J. Galanter, Lindsey A. Roth, S. Huntsman, C. Eng, Sam S. Oh, S. Yee, Lawrence Lin, C. Bustamante, A. Moreno-Estrada, Karla Sandoval, Adam Davis, L. Borrell, H. Farber, R. Kumar, P. Avila, E. Brigino-Buenaventura, R. Chapela, J. Ford, M. Lenoir, F. Lurmann, Kelley Meade, Denise Serebrisky, Shannon M. Thyne, W. Rodriguez-Cintron, Śaunak Sen, J. Rodriguez-Santana, Ryan D. Hernandez, K. Giacomini, E. Burchard   +31 more
semanticscholar   +1 more source

Effects of Live and Heat‐Treated Bifidobacterium longum CECT 7347 in Adults With Allergic Rhinitis: A Randomised, Double‐Blind, Placebo‐Controlled Trial

Allergy, EarlyView.
This randomized, double‐blind, placebo‐controlled trial evaluated the effects of live probiotic and HT postbiotic B. longum CECT 7347 in adults with moderate–severe allergic rhinitis. Postbiotic supplementation for 8 weeks significantly reduced CSMS and dSS, exceeding the established CSMS MCID with a 33% greater improvement, when compared to placebo ...
Ana Cardoso, Malwina Naghibi, Eric Climent, Andrea Rodenes‐Gavidia, Araceli Lamelas, Laura Llobregat, Juan Martínez‐Blanch, Daniel Friedman, Vineetha Vijayakumar, Richard Day   +9 more
wiley   +1 more source

Ultra‐Processed Food Consumption and Childhood Allergic Diseases: Increased Risk of Asthma Onset in the SENDO Project

Allergy, EarlyView.
The SENDO cohort study (2015–2024) prospectively analyzed the impact of ultra‐processed food (UPF) consumption on asthma and atopy in 1,546 Spanish children. Higher UPF intake (NOVA 4 classification) was significantly associated with an increased risk of asthma but not atopy, atopic dermatitis, neumoallergen sensitation, food allergy over five years ...
O. Galindo, M. J. Goikoetxea, L. Moreno‐Galarraga, L. Argiz, J. M. Moreno‐Villares, Victor de la O, N. Martín‐Calvo   +6 more
wiley   +1 more source

Genome-wide linkage analysis of bronchodilator responsiveness and post-bronchodilator spirometric phenotypes in chronic obstructive pulmonary disease

, 2003
Chronic obstructive pulmonary disease (COPD) is a common, complex disease associated with significant and increasing morbidity and mortality. The cardinal feature of COPD is persistent airflow obstruction, measured by reductions in quantitative ...
Celedon, JC, Chapman, HA, Silverman, EK, Speizer, FE, Palmer, LJ, Weiss, ST   +5 more
core   +1 more source

Type‐2‐Inflammatory‐Diseases Share Comorbidities, Molecular Signatures, IL4/IL13 Genetics, and Response to IL4/IL13 Blockade

Allergy, EarlyView.
Studies suggest that type 2 inflammatory diseases are driven by overactivation of the IL4/IL13 pathway, manifesting differently in distinct tissues. We performed quantitative analyses using several large independent datasets to explore the interrelation of type 2 inflammatory diseases based on co‐prevalence, genetic predispositions, and transcriptomic ...
Jennifer D. Hamilton, Manuel A. R. Ferreira, Wei Keat Lim, Carlo Sidore, Matthew F. Wipperman, Wenzhen Ge, Xue Song, Changming Xia, Julie E. Horowitz, Andrea T. Hooper, Sara C. Hamon, Jennifer Maloney, Jamie M. Orengo, Zhen Chen, Stephanie Amato Ricci, Bolanle Akinlade, Aris Baras, Gary Herman, Brandy L. Bennett, George D. Yancopoulos   +19 more
wiley   +1 more source

Efficacy and safety of once-daily aclidinium in chronic obstructive pulmonary disease. [PDF]

, 2011
BACKGROUND: The long-term efficacy and safety of aclidinium bromide, a novel, long-acting muscarinic antagonist, were investigated in patients with moderate to severe chronic obstructive pulmonary disease (COPD).
Fabbri, Leonardo M., Caracta, C, Stephen I Rennard, James F Donohue, Caracta, Cynthia, Gil, Esther Garcia, Jones, PW, Donohue, JF, Magnussen, Helgo, Bateman, ED, Nicholas J Gross, Bateman, Eric D, Channez, Pascal, Fabbri, L, Agusti, Alvar, Lamarca R, Gross Nicholas J, Magnussen Helgo, Gil, Esther G, Cynthia Caracta, Caracta Cynthia, Chanez P, Jones, Paul, Agusti Alvar, Paul W Jones, Lamarca, R, Bateman, Eric D., Jones, Paul W., Gross, Nicholas J, Esther Garcia Gil, Agusti A, Gil, Esther, Rosa Lamarca, Alvar Agusti, Jones, Paul W, Chanez, P, Fabbri Leonardo, Magnussen H, Helgo Magnussen, Donohue JF, Gil, EG, Magnussen, H, Donohue James F, Gross, Nicholas J., Garcia Gil, Esther, Jones PW, Rennard, SI, Lamarca, Rosa, Gross NJ, Agusti, A, Caracta C, Eric D Bateman, Jones Paul W, Gil Esther, Chanez, Pascal, Donohue, James F, Donohue, James F., Bateman Eric D, Rennard, Stephen I., Bateman, Eric, Rennard Stephen I, Gross, Nicholas, Gross, NJ, Pascal Chanez, Rennard, Stephen, Bateman ED, Agustí García-Navarro, Àlvar, Lamarca Rosa, Chanez Pascal, Rennard, Stephen I, Rennard SI, Gil EG, Fabbri, Leonardo, Leonardo Fabbri, Donohue, James   +74 more
core   +1 more source

Preventive Application of House Dust Mite‐Sublingual Immunotherapy Induces Blocking Antibodies in Sensitized Preschool Children

Allergy, EarlyView.
HDM‐pSLIT induced IgG, IgG1, and IgG4 specific to major HDM allergens in sensitized non‐allergic preschool children without increasing HDM‐sIgE. It blunted the development of new sensitizations and reduced HDM reactivity in skin and basophils. HDM‐pSLIT treated children displayed a blocking effect on HDM‐induced basophil activation.
Varsha Dwivedi, Klara Schmidthaler, Hilal Demir, Justyna Sieber, René Gaupmann, Livia Mia Gona‐Höpler, Christina Bannert, Saskia Gruber, Eleonora Dehlink, Thomas Eiwegger, Alexandra Graf, Barbara Bohle, Zsolt Szépfalusi   +12 more
wiley   +1 more source

Development of a self-scored persistent airflow obstruction screening questionnaire in a general Japanese population: the Hisayama study

International Journal of COPD, 2017
Takuya Samukawa,1,* Koichiro Matsumoto,2,* Go Tsukuya,1 Chihaya Koriyama,3 Satoru Fukuyama,2 Akifumi Uchida,1 Keiko Mizuno,1 Hironori Miyahara,4 Yutaka Kiyohara,5 Toshiharu Ninomiya,6 Hiromasa Inoue1 1Department of Pulmonary Medicine, Graduate School of
Samukawa T, Matsumoto K, Tsukuya G, Koriyama C, Fukuyama S, Uchida A, Mizuno K, Miyahara H, Kiyohara Y, Ninomiya T, Inoue H   +10 more
doaj  

Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Improves Lung Function versus Monotherapies in GOLD Category A Patients with COPD: Pooled Data from the Phase III PINNACLE Studies

International Journal of COPD, 2020
Fernando J Martinez,1 Klaus F Rabe,2 Brian J Lipworth,3 Samir Arora,4 Martin Jenkins,5 Ubaldo J Martin,6 Colin Reisner6,7 1Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA; 2Department of Pneumonology ...
Martinez FJ, Rabe KF, Lipworth BJ, Arora S, Jenkins M, Martin UJ, Reisner C   +6 more
doaj  

The Potential Involvement of an ATP-Dependent Potassium Channel-Opening Mechanism in the Smooth Muscle Relaxant Properties of Tamarix dioica Roxb.

Biomolecules, 2019
Background: Tamarix dioica is traditionally used to manage various disorders related to smooth muscle in the gastrointestinal, respiratory, and cardiovascular systems.
Syeda Madiha Imtiaz, Ambreen Aleem, Fatima Saqib, Alexe Nicolae Ormenisan, Andrea Elena Neculau, Costin Vlad Anastasiu   +5 more
doaj   +1 more source