Results 101 to 110 of about 57,781 (271)

Safety, tolerability, pharmacokinetics and pharmacodynamics of the spleen tyrosine kinase inhibitor BI 894416 in healthy volunteers and patients with asthma

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Spleen tyrosine kinase (SYK) has broad biological functions in inflammation and immunity. The orally administered SYK inhibitor BI 894416 was investigated in a single‐rising‐dose Phase I study in healthy volunteers and in a combined single‐ and multiple‐rising‐dose Phase Ib study in patients with mild asthma ...
Saskia Carstensen‐Aurèche, Tobias Litzenburger, Dorothy De Sousa, Reinhard Sailer, Ewald Benediktus, Denis Delic, Fabian Müller, Meike Müller, Jens M. Hohlfeld   +8 more
wiley   +1 more source

Regional lung deflation with increased airway volume underlies the functional response to bronchodilators in chronic obstructive pulmonary disease

Physiological Reports, 2019
Bronchodilators, including long‐acting muscarinic antagonists (LAMAs), improve airflow limitation and lung hyperinflation in patients with chronic obstructive pulmonary disease (COPD).
Naoya Tanabe, Susumu Sato, Shigeo Muro, Hiroshi Shima, Tsuyoshi Oguma, Kazuya Tanimura, Atsuyasu Sato, Toyohiro Hirai   +7 more
doaj   +1 more source

Optimization of Bronchodilator Treatment in COPD: A Comparison of the Glycopyrrolate/Formoterol Combination vs. Formoterol Alone [PDF]

Kirkuk Journal of Medical Sciences
Background: Using a glycopyrrolate/formoterol combination to manage COPD patients is considered a new method. The objectives of this study are to evaluate the effectiveness of the glycopyrrolate/formoterol combination against formoterol alone in ...
Hiwa Saber, Ahmed Abdullah
doaj   +1 more source

Treatment of COPD with Long-Acting Bronchodilators: Association Between Early and Longer-Term Clinically Important Improvement

International Journal of COPD, 2021
Claus F Vogelmeier,1 Ian P Naya,2,3 François Maltais,4 Leif Bjermer,5 Edward M Kerwin,6 Lee Tombs,7 Paul W Jones,2 Chris Compton,2 David A Lipson,8,9 Isabelle H Boucot2,10 1Department of Medicine, Pulmonary and Critical Care Medicine, University ...
Vogelmeier CF, Naya IP, Maltais F, Bjermer L, Kerwin EM, Tombs L, Jones PW, Compton C, Lipson DA, Boucot IH   +9 more
doaj  

A systematic review of the association between pulmonary tuberculosis and the development of chronic airflow obstruction in adults [PDF]

, 2012
Includes abstract.Includes bibliographical references.Pulmonary tuberculosis (TB) as a cause of COPD is debated, with some, but not all evidence suggesting an association between the two conditions.
Allwood, Brian
core  

Comparative study of the bronchodilator efficacy and adverse effects of salbutamol and hyoscine butylbromide in horses with severe asthma

Journal of Veterinary Internal Medicine
Background Salbutamol and hyoscine butylbromide (HBB) are commonly used bronchodilators in horses with severe asthma (SA). Objective To compare the bronchodilation potency, duration, and adverse effects of salbutamol and HBB in SA.
Berta Mozo Vives, Sophie Mainguy‐Seers, Jean‐Pierre Lavoie   +2 more
doaj   +1 more source

Mechanism of Cardiac Arrest in Fatal Anaphylaxis

Clinical &Experimental Allergy, EarlyView.
This population‐based retrospective cohort study of clinical deterioration in anaphylaxis deaths identifies bronchospasm as the preponderant cause of cardiac arrest, especially in food and drug allergen exposures. The clinical implication is that anaphylaxis guidelines require appropriate emphasis on respiratory involvement and treatment to prevent ...
Ben A. McKenzie, Stuart D. Marshall, Lena A. Sanci, Catriona Moynihan, Chris Selman, Jo A. Douglass   +5 more
wiley   +1 more source

A comparative study of bronchodilator response: utilizing pre-bronchodilator versus predicted normal values

BMC Pulmonary Medicine
Background A positive bronchodilator response has been defined as a 12% increase in the forced expiratory volume in one second (FEV1) or forced vital capacity (FVC) from their respective pre-bronchodilator values, combined with at least a 0.2 L absolute ...
Afe Alexis, Naresh M. Punjabi, Kyle Grealis, Adam Wanner   +3 more
doaj   +1 more source

Prevalence of Type 2 Inflammation in Chronic Obstructive Pulmonary Disease Patients With Frequent Exacerbations

Allergy, EarlyView.
Mireille C. Melles, Johannes C. C. M. in 't Veen, Dirk‐Jan Slebos, Frits M. E. Franssen, Marlies van Dijk, Pieter‐Paul W. Hekking   +5 more
wiley   +1 more source

Use of a 3D‐printed custom‐designed tracheostomy tube to stabilise a permanent tracheostoma in a 25‐year‐old Icelandic mare

Equine Veterinary Education, EarlyView.
Summary A 25‐year‐old Icelandic mare diagnosed with bilateral temporohyoid‐osteoarthropathy, moderate pharyngeal instability and bilateral laryngeal paralysis was presented because of intermittent stridor and dyspnoea worsening during exercise. As a previous ceratohyoidectomy had not improved these symptoms substantially, a permanent tracheostomy was ...
D. C. Debald, J. P. Schramel, E. Haltmayer, N. M. Biermann   +3 more
wiley   +1 more source