Results 91 to 100 of about 68,751 (311)

Diagnostic value of post-bronchodilator pulmonary function testing to distinguish between stable, moderate to severe COPD and asthma

, 2008
Daphne C Richter1, James R Joubert1, Haylene Nell1, Mace M Schuurmans2, Elvis M Irusen21Tiervlei Trial Centre, Karl Bremer Hospital, Bellville, RSA; 2Respiratory Research Unit, Department of Internal Medicine, Faculty of Health Sciences, University of ...
Elvis M Irusen, Daphne C Richter, Mace M Schuurmans, James R Joubert, Haylene Nell   +4 more
core  

Is Asthma Remission a New Achievable Goal? A Review of the Current Drug‐Related Evidence and Predictors

Allergy, EarlyView.
ABSTRACT Advances in asthma therapies have shown that clinical remission may be an achievable therapeutic goal for patients with asthma. This review discusses the current definitions of remission in asthma, the predictors of remission, airway inflammation/epithelial damage in asthma remission, airway remodeling, paradigms in defining remission and ...
Fatma Esra Gunaydin, Giulia Marcassa, Bianca Olivieri, Gianenrico Senna, Marco Caminati   +4 more
wiley   +1 more source

A genome-wide association study of bronchodilator response in asthmatics

The Pharmacogenomics Journal, 2013
Reversibility of airway obstruction in response to β2-agonists is highly variable among asthmatics, which is partially attributed to genetic factors. In a genome-wide association study of acute bronchodilator response (BDR) to inhaled albuterol, 534 290 ...
Q. Duan, J. Lasky-Su, B. Himes, W. Qiu, A. Litonjua, A. Damask, Ross Lazarus, B. Klanderman, C. Irvin, S. Peters, J. Hanrahan, J. Lima, F. Martinez, D. Mauger, V. Chinchilli, M. Soto-Quiros, L. Avila, J. Celedón, C. Lange, S. Weiss, K. Tantisira   +20 more
semanticscholar   +1 more source

Effect of Dupilumab on Airway Inflammation in Patients With Persistent Asthma

Allergy, EarlyView.
EXPEDITION (NCT02573233) assessed the effects of dupilumab on airway inflammation in patients with persistent asthma using bronchoscopy and gene expression analysis. Dupilumab showed no appreciable effect on inflammatory cell types in biopsies or BALF samples.
Michael E. Wechsler, Sally E. Wenzel, Steve D. Groshong, Mario Castro, Ian D. Pavord, Klaus F. Rabe, Elizabeth Laws, Alexandre Jagerschmidt, Kaitlyn Gayvert, Sivan Harel, Jennifer D. Hamilton, Nikhil Amin, Lu Zhang, Heming Xing, Anissa Elfakir, Bema Coulibaly, Souâd Naimi, Sara Hamon, Paul J. Rowe, Frank Nestle, Danen M. Cunoosamy, Emanuele de Rinaldis, Leda P. Mannent   +22 more
wiley   +1 more source

Randomized dose-finding study of batefenterol via dry powder inhaler in patients with COPD

International Journal of COPD, 2019
Courtney Crim,1 Michael L Watkins,1 Eric D Bateman,2 Gregory J Feldman,3 Isabelle Schenkenberger,4 Edward M Kerwin,5 Catriona Crawford,6 Krishna Pudi,7 Shuyen Ho,8 Charlotte Baidoo,9 Ramiro Castro-Santamaria10 1GSK, Research and Development, Research ...
Crim C, Watkins ML, Bateman ED, Feldman GJ, Schenkenberger I, Kerwin EM, Crawford C, Pudi K, Ho S, Baidoo C, Castro-Santamaria R   +10 more
doaj  

Impact of bronchodilator therapy on exercise tolerance in COPD

, 2010
B AguilaniuHYLAB, Laboratory of Clinical Physiology and Exercise, Grenoble, FranceAbstract: Exercise tolerance is an important parameter in patients with COPD and a primary goal of treatment is to reduce dyspnea to facilitate physical activities and ...
B Aguilaniu
core  

‘The blue one takes a battering’ why do young adults with asthma overuse bronchodilator inhalers? A qualitative study

BMJ Open, 2013
Objective Overuse of short-acting bronchodilators is internationally recognised as a marker of poor asthma control, high healthcare use and increased risk of asthma death. Young adults with asthma commonly overuse short-acting bronchodilators.
S. Cole, C. Seale, C. Griffiths
semanticscholar   +1 more source

In Vitro Performance of Valved Holding Chambers in Paediatric Asthma Controller Therapy

Acta Paediatrica, EarlyView.
ABSTRACT Aim Research on the drug delivery of inhaled corticosteroids and combination medications via valved holding chambers (VHCs) with children's breathing patterns is limited. We aimed to evaluate the in vitro performance of commercially available VHCs without facemasks under preschooler breathing conditions, focusing on total delivered dose and ...
Laura Ojanperä, Lauri Lehtimäki, Péter Csonka   +2 more
wiley   +1 more source

Bronchodilator reversibility testing: Laboratory practices in Australia and New Zealand

, 2004
Objectives: To determine the variation in the methods used to assess and interpret the reversibility of airflow limitation in lung-function laboratories throughout Australia and New Zealand.
Johns, David P., Reid, David W., Borg, Brigitte M., Walters, E. Haydn   +3 more
core   +1 more source

Bronchodilator response during acute viral bronchiolitis in infancy

, 1985
Bronchodilator responsiveness was assessed by measuring specific respiratory conductance before and after inhalation of aerosolized bronchodilator in 50 infants who had acute bronchiolitis due to respiratory syncytial virus infection.
Soto, Manuel E., Landau, Louis I., Taussig, Lynn M., Uren, Eric, Sly, Peter D.   +4 more
core   +2 more sources