Results 61 to 70 of about 61,454 (303)

A Combined Model‐Based Meta‐Analysis of Aggregated and Individual FEV1 Data From Randomized COPD Trials

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Model‐based meta‐analysis allows integration of aggregated‐level data (AD) from different clinical trials in one model to assess population efficacy/safety. However, AD is limited in individual‐level information, while individual‐patient‐level data (IPD) are hard to obtain. Combined modeling may take advantage of both sources.
Liang Yang, Carolina Llanos‐Paez, Shuying Yang, Claire Ambery, Alienor Berges, Maria C. Kjellsson, Mats O. Karlsson   +6 more
wiley   +1 more source

Glycopyrrolate/Formoterol Fumarate Metered Dose Inhaler Improves Lung Function versus Monotherapies in GOLD Category A Patients with COPD: Pooled Data from the Phase III PINNACLE Studies

International Journal of COPD, 2020
Fernando J Martinez,1 Klaus F Rabe,2 Brian J Lipworth,3 Samir Arora,4 Martin Jenkins,5 Ubaldo J Martin,6 Colin Reisner6,7 1Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medicine, New York, NY, USA; 2Department of Pneumonology ...
Martinez FJ, Rabe KF, Lipworth BJ, Arora S, Jenkins M, Martin UJ, Reisner C   +6 more
doaj  

Estimating the U.S. prevalence of chronic obstructive pulmonary disease using pre- and post-bronchodilator spirometry: the National Health and Nutrition Examination Survey (NHANES) 2007–2010

Respiratory Research, 2013
BackgroundDuring 2007–2010, the National Health and Nutrition Examination Survey (NHANES) conducted a spirometry component which obtained pre-bronchodilator pulmonary lung function data on a nationally representative sample of US adults aged 6–79 years ...
Timothy Tilert, C. Dillon, R. Paulose‐Ram, E. Hnizdo, B. Doney   +4 more
semanticscholar   +1 more source

A Novel Questionnaire and Algorithm for Work‐Related Asthma Screening and Surveillance: An EAACI Task Force Report

Allergy, EarlyView.
ABSTRACT Introduction Work‐related exposures contribute to one in six new‐onset adult asthma cases and exacerbation of one in five existing cases, which together are termed ‘work‐related asthma’ (WRA). A valid and standardized WRA questionnaire is needed for workplace surveillance and epidemiological studies.
Mohamed F. Jeebhay, Hille Suojalehto, Susan M. Tarlo, Eva Suarthana, Paul Cullinan, Irmeli Lindström, Paola Mason, Xavier Munoz, Monika Raulf, Marcela Valverde, Jolanta Walusiak‐Skorupa, Paul Henneberger   +11 more
wiley   +1 more source

Treatment-Refractory Tracheobronchitis in Crohn's Disease: A Rare Pulmonary Manifestation of Inflammatory Bowel Disease. [PDF]

Respirol Case Rep
In this report, we present a case of tracheobronchitis in Crohn's disease presenting with a chronic productive cough while on infliximab. The diagnosis was made on bronchoscopy, which revealed inflammation of the trachea and main bronchi, with biopsies demonstrating squamous cell metaplasia consistent with pulmonary inflammatory bowel disease ...
Gurieff G, Shivakumar S, Lee J, Macrae F, Leong TL.   +4 more
europepmc   +2 more sources

Combination bronchodilator therapy in the management of chronic obstructive pulmonary disease

Respiratory Research, 2013
Chronic obstructive pulmonary disease (COPD) represents a significant cause of global morbidity and mortality, with a substantial economic impact. Recent changes in the Global initiative for chronic Obstructive Lung Disease (GOLD) guidance refined the ...
D. Tashkin, G. Ferguson
semanticscholar   +1 more source

Complementary Predictors for Asthma Attack Prediction in Children: Salivary Microbiome, Serum Inflammatory Mediators, and Past Attack History

Allergy, EarlyView.
In this two‐phase study, school‐aged children were classified as at risk or no‐risk based on severe attacks during one‐year follow‐up. Four types of prediction models were developed. Salivary bacteria and serum inflammatory markers, while informative alone, complement past asthma attacks in predicting future attack risk.
Shahriyar Shahbazi Khamas, Paul Brinkman, Anne H. Neerincx, Susanne J. H. Vijverberg, Simone Hashimoto, Jelle M. Blankestijn, Jan Willem Duitman, Tamara Dekker, Barbara S. Smids, Suzanne W. J. Terheggen‐Lagro, René Lutter, Nariman K. A. Metwally, Fleur Sondaal, Eric G. Haarman, Peter J. Sterk, Ian M. Adcock, Charles Auffray, Corinna Bang, Aruna T. Bansal, Heike Buntrock‐Döpke, Klaus Bønnelykke, Andrew Bush, Bo Lund Chawes, Kian Fan Chung, Paula Corcuera‐Elosegui, Sven‐Erik Dahlén, Ratko Djukanovic, Louise J. Fleming, Stephen J. Fowler, Andre Franke, Urs Frey, Mario Gorenjak, Susanne Brandstetter, Susanne Harner, Gunilla Hedlin, Michael Kabesch, Nazanin Zounemat‐Kermani, Parastoo Kheirolldein, Alexander Kiefer, Jon R. Konradsen, Aletta D. Kraneveld, Leyre López‐Fernández, Clare S. Murray, Björn Nordlund, Maria Pino‐Yanes, Uroš Potočnik, Graham Roberts, Jakob Stokholm, Søren Johannes Sørensen, Olaia Sardón‐Prado, Dominick E. Shaw, Florian Singer, Ana R. Sousa, Jonathan Thorsen, Antoaneta A. Toncheva, Nadja H. Vissing, Christine Wolff, Mahmoud I. Abdel‐Aziz, Anke H. Maitland‐van der Zee, on behalf of the SysPharmPediA and U‐BIOPRED Consortia   +59 more
wiley   +1 more source

Natural History of Airway Hyperresponsiveness and Its Association With Asthma Traits

Allergy, EarlyView.
AHR improves in most children over adolescence when its relationship with asthma changes. AHR is better at ruling out asthma in children, while it is superior at ruling in asthma in young adults. Age should be considered when interpreting AHR, and different cutoffs might be required for children and adults.
Sophie Carra, Hongmei Zhang, Ramesh J. Kurukulaaratchy, Syed Hasan Arshad   +3 more
wiley   +1 more source

Dual inhibitory activities of Adhatoda Vasica against cyclooxygenase and lipoxygenase

International Journal of Endorsing Health Science Research, 2013
Adhatoda vasica (L.) Nees is a well-known plant drug in Ayurvedic and Unani medicine. It has been used for the treatment of various diseases, particularly for the treatment of inflammatory and cardiovascular diseases.
Sagheer Ahmed, Saima Gul, Humera Gul, Muhammad Hanif Bangash   +3 more
doaj   +1 more source

Molecular IgE Sensitization Profiling With Micro‐Arrayed Allergen Molecules in Adult Patients With Asthma From the LEAD Cohort: A Precision Medicine Approach

Allergy, EarlyView.
In the LEAD cohort, micro‐arrayed asthma allergens identified IgE‐sensitized adult asthma patients. Compared to non‐IgE‐sensitized patients, they had better lung function, took less ICS and had lower eosinophils. IgE‐sensitized patients were sensitized to a handful of respiratory allergen sources and may benefit from allergen‐specific forms of ...
Huey‐Jy Huang, Robab Breyer‐Kohansal, Katarzyna Niespodziana, Charmaine J. M. Lim, Marie‐Kathrin Breyer, Rudolf Valenta, Sylvia Hartl, the Allergochip Working Group, Maria‐Roxana Buzan, Kuan‐Wei Chen, Monica Daniela Cotarcă, Alexandra Dubovets, Pia Gattinger, Alexander Karaulov, Evgenii Kozlov, Carmen Panaitescu, Daria Trifonova, Mikhail Tulaev, Susanne Vrtala, Milena Weber, Lauriana‐Eunice Zbîrcea   +20 more
wiley   +1 more source