Results 71 to 80 of about 62,270 (271)

Recent Progress in Treating Airway Mucus Hypersecretion by Targeting the Epidermal Growth Factor Receptor Signaling Pathway

Pediatric Discovery, EarlyView.
ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang, Fuping Yang, Chunyu Yan, Yu Deng, Enmei Liu   +4 more
wiley   +1 more source

Combination formoterol and inhaled steroid versus beta(2)-agonist as relief medication for chronic asthma in adults and children (Review) [PDF]

, 2009
Background Formoterol has a fast onset of action and can therefore be used to relieve symptoms of asthma. A combination inhaler can deliver formoterol with different doses of inhaled corticosteroid; when used as a reliever both drugs will be delivered ...
Adams, Balanzat, Berggren, Bisgaard, Bisgaard, Bleecker, Bousquet, British Thoracic Society, Bruce, Buhl, Buhl, Cates, Christopher, Greenstone, Haahtela, Haahtela, Higgins, Higgins, Ind, Johansson, Jonkers, Kuna, Kuna, Lundborg, Ni Chroinin, O'Byrne, O'Byrne, O'Byrne, O'Byrne, O'Byrne, Palmqvist, Price, Price, Rabe, Rabe, Rabe, Richter, Salpeter, Scicchitano, Sears, Sovani, Stallberg, Tattersfield, Tattersfield, Vogelmeier, Vogelmeier, Walters   +46 more
core   +1 more source

Glucocorticoid‐Induced TNFR‐Related Ligand as a Biomarker for Diagnosis and Severity of Asthma in Children

Pediatric Discovery, EarlyView.
Our study demonstrates elevated GITRL expression in HDM‐exposed dendritic cells (in vitro), murine asthma models, and pediatric asthma patients, and reveals a direct association between GITRL levels and disease severity in children. ABSTRACT Currently, there are no reliable pediatric biomarkers for assessing the severity of asthma. Therefore, the study
Yuehan Li, Yan Li, Jinying Xiang, Yinying Ren, Mi Zhou, Fang Deng, Zhou Fu, Fengxia Ding   +7 more
wiley   +1 more source

Dual inhibitory activities of Adhatoda Vasica against cyclooxygenase and lipoxygenase

International Journal of Endorsing Health Science Research, 2013
Adhatoda vasica (L.) Nees is a well-known plant drug in Ayurvedic and Unani medicine. It has been used for the treatment of various diseases, particularly for the treatment of inflammatory and cardiovascular diseases.
Sagheer Ahmed, Saima Gul, Humera Gul, Muhammad Hanif Bangash   +3 more
doaj   +1 more source

A Combined Model‐Based Meta‐Analysis of Aggregated and Individual FEV1 Data From Randomized COPD Trials

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Model‐based meta‐analysis allows integration of aggregated‐level data (AD) from different clinical trials in one model to assess population efficacy/safety. However, AD is limited in individual‐level information, while individual‐patient‐level data (IPD) are hard to obtain. Combined modeling may take advantage of both sources.
Liang Yang, Carolina Llanos‐Paez, Shuying Yang, Claire Ambery, Alienor Berges, Maria C. Kjellsson, Mats O. Karlsson   +6 more
wiley   +1 more source

Acute bronchitis: challenges of diagnosis and treatment

Медицинский совет, 2013
Internal medicine specialists often have difficulty in making diagnosis and defining the type of treatment for patients with first time long-lasting cough or newly developed bronchial obstruction syndrome. Acute bronchitis (AB) is one of reasons of cough
I. V. Leschenko
doaj   +1 more source

Relationship between FEV1 change and patient-reported outcomes in randomised trials of inhaled bronchodilators for stable COPD: a systematic review. [PDF]

, 2011
BACKGROUND: Interactions between spirometry and patient-reported outcomes in COPD are not well understood. This systematic review and study-level analysis investigated the relationship between changes in FEV1 and changes in health status with ...
Bourbeau, J, Capkun-Niggli, G, Cerulli, A, Jones, PW, Westwood, M, Worthy, G   +5 more
core   +2 more sources

Identification of Clinically Distinct Clusters in Patients With Severe COPD Using Circulating Blood Cell Population Parameters

Respirology, EarlyView.
This study investigated whether blood cell population data, in addition to cell counts, can identify clinically relevant COPD subgroups. Four distinct inflammatory profiles were identified with distinct clinical characteristics. Cell population data have the potential to provide additional insights beyond inflammatory cell counts and improve patient ...
Pauline J. M. Kuks, Jorine E. Hartman, Else A. M. D. ter Haar, L. Joost van Pelt, Dirk‐Jan Slebos, Maarten van den Berge, Simon D. Pouwels   +6 more
wiley   +1 more source

Role of Forced Expiratory Volume in Third second (FEV3) as An Alternative to Forced Vital Capacity (FVC) in Assessing Bronchodilator Response in Patients with Chronic Obstructive Airway Diseases

The Iraqi Journal of Medical Sciences, 2020
Background: Spirometry is a physiological procedure used as a diagnostic tool for disease diagnosis; e.g. obstructive pulmonary diseases such as asthma or chronic obstructive pulmonary disease (COPD).
Alaa Jizar, Zeinab Hashim, Ahmed Jasim
doaj   +1 more source

Genome-Wide Association Study of Bronchodilator Drug Response (BDR) in Minority Children with Asthma Provides Insights into Its Genetic Risk Factors [PDF]

, 2021
Jin Hui Joo, Angel C. Y. Mak, Shujie Xiao, Patrick Sleiman, Diane Hu, Scott Huntsman, Celeste Eng, Mengyuan Kan, Avantika R. Diwadkar, Hákon Hákonarson, L. Keoki Williams, EG Burchard, Blanca E. Himes   +12 more
openalex   +1 more source