Results 41 to 50 of about 45,823 (234)

Estudo comparativo de técnicas de screening para avaliação da atividade anti-bacteriana de extratos brutos de espécies vegetais e de substâncias puras Comparative study of screening techniques for antibacterial activity evaluation of plant crude extracts and pure compounds

Química Nova, 2008
In this work, the effectiveness of four screening techniques (three techniques of the diffusion method and one microdilution broth method) were compared.
Everton Giovanni Alves, Adriana Helena Chicharo Vinholis, Luciana Assirati Casemiro, Niege Araçari Jacometti Cardoso Furtado, Márcio Luis Andrade e Silva, Wilson Roberto Cunha, Carlos Henrique Gomes Martins   +6 more
doaj   +1 more source

Dual‐Functional Silent‐Region SERS Nanoplatform for Real‐Time Bacterial Tracking and Wound Healing Therapy

Advanced Science, EarlyView.
ABSTRACT Bacterial wound infections, particularly those caused by Escherichia coli and Pseudomonas aeruginosa, are difficult to treat due to biofilm formation, multidrug resistance, and chronic inflammation. Here, we report a multifunctional nanoplatform based on a surface‐enhanced Raman scattering (SERS) probe that enables simultaneous photodynamic ...
Hanbin Deng, Rui Wang, Dianqi Zhang, Wei Zhang, Jaebum Choo, Fabiao Yu, Shaowen Cheng   +6 more
wiley   +1 more source

Comparative Evaluation of VITEK 2 and Broth Microdilution Methods for Colistin Antimicrobial Susceptibility Test

Namık Kemal Tıp Dergisi, 2020
Aim:Accurate susceptibility testing methods are needed for colistin. In our study, we aimed to determine the efficacy of VITEK 2 (bioMérieux, Marcy-L’Etoile, France) in detecting colistin sensitivity by comparing the broth microdilution method with VITEK
Birol ŞAFAK, Özge TOMBAK, Aynur EREN TOPKAYA   +2 more
doaj   +1 more source

Antibiotic susceptibility pattern of Portuguese environmental Legionella isolates

Frontiers in Cellular and Infection Microbiology, 2023
IntroductionLegionnaires’ Disease is a pneumonia caused by Legionella spp., currently treated empirically with fluoroquinolones and macrolides. In this study, we aim to describe the antibiotic susceptibility pattern of environmental Legionella recovered ...
Carolina Cruz, Lúcia Rodrigues, Filipa Fernandes, Ricardo Santos, Paulo Paixão, Maria Jesus Chasqueira   +5 more
doaj   +1 more source

Torulopsis glabrata: azole susceptibilities by microdilution colorimetric and macrodilution broth assays [PDF]

Journal of Clinical Microbiology, 1995
Fluconazole and itraconazole MICs were determined by both the standard macrodilution method of the National Committee for Clinical Laboratory Standards and a colorimetric broth microdilution method for 140 isolates of Torulopsis (Candida) glabrata obtained over a 15-year period.
R N, Tiballi, L T, Zarins, X, He, C A, Kauffman   +3 more
openaire   +2 more sources

Pyrazole‐Derived Antibacterial Compounds Effectively Treat Methicillin‐Resistant Staphylococcus Aureus Infections by Inhibiting Aspartate Transcarbamoylase

Advanced Science, EarlyView.
This study unveils a novel antibacterial mechanism against MRSA, in which the compound Py‐27 selectively targets and inhibits aspartate transcarbamoylase (ATCase), a key enzyme in pyrimidine synthesis. This inhibition disrupts DNA replication, induces oxidative damage, leading to potent bactericidal activity.
Xiaorong Yang, Xinyuan Cao, Lixia Dai, Feng Yang, Jing Wang, Yudong Ma, Tong Bu, Zile Gong, Xueyan Liu, Changcai Bai, Xiaolou Miao, Xiaofei Shang   +11 more
wiley   +1 more source

High Rates of Antimicrobial Resistance in Rapidly Growing Mycobacterial Infections in Taiwan

Pathogens, 2022
Rapidly growing mycobacteria (RGM) has gained increasing clinical importance, and treatment is challenging due to diverse drug resistance. The minimum inhibitory concentrations (MIC) of 13 antimicrobial agents using modified broth microdilution and E ...
Hui-Zin Tu, Herng-Sheng Lee, Yao-Shen Chen, Susan Shin-Jung Lee   +3 more
doaj   +1 more source

The Natural Product Corramycin Acts as a DNA Gyrase Poison and Overcomes Fluoroquinolone Resistance in Mycobacterium tuberculosis

Advanced Science, EarlyView.
Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries, Jennifer Herrmann, Michael Dal Molin, Yaëlle Wormser, Timo Risch, Yunsheng Gao, Gareth Prosser, Francesca Gubellini, Ariel Mechaly, Joshua B. Wallach, Anthony Castro, Arka Banerjee, Sari Rasheed, Alexander Horn, Mathias Müsken, Michael Kurz, Lindsay Sonnenkalb, Viola Dreyer, Stefan Niemann, Sönke Andres, Dirk Schnappinger, Uli Kazmaier, Norbert Reiling, Rolf Müller, Jan Rybniker, Stéphanie Petrella   +25 more
wiley   +1 more source

Recommendation for a Standardised Method of Broth Microdilution Susceptibility Testing for Porcine Bordetella bronchiseptica. [PDF]

PLoS ONE, 2015
The objective was to establish and standardise a broth microdilution susceptibility testing method for porcine Bordetella (B.) bronchiseptica. B. bronchiseptica isolates from different geographical regions and farms were genotyped by macrorestriction ...
Sandra Prüller, Cornelia Frömke, Heike Kaspar, Günter Klein, Lothar Kreienbrock, Corinna Kehrenberg   +5 more
doaj   +1 more source

Multisite Reproducibility of the Broth Microdilution Method for Susceptibility Testing of Nocardia Species [PDF]

Journal of Clinical Microbiology, 2012
ABSTRACT Antimicrobial susceptibility testing (AST) of clinical isolates of Nocardia is recommended to detect resistance to commonly used antimicrobial agents; such testing is complicated by difficulties in inoculum preparation and test interpretation.
Patricia S, Conville, Barbara A, Brown-Elliott, Richard J, Wallace, Frank G, Witebsky, Deloris, Koziol, Geraldine S, Hall, Scott B, Killian, Cindy C, Knapp, David, Warshauer, Tam, Van, Nancy L, Wengenack, Sharon, Deml, Gail L, Woods   +12 more
openaire   +2 more sources