Results 61 to 70 of about 157,032 (265)

High Rates of Antimicrobial Resistance in Rapidly Growing Mycobacterial Infections in Taiwan

Pathogens, 2022
Rapidly growing mycobacteria (RGM) has gained increasing clinical importance, and treatment is challenging due to diverse drug resistance. The minimum inhibitory concentrations (MIC) of 13 antimicrobial agents using modified broth microdilution and E ...
Hui-Zin Tu, Herng-Sheng Lee, Yao-Shen Chen, Susan Shin-Jung Lee   +3 more
doaj   +1 more source

Multi‐Targeting Carnosic Acid Kills Drug‐Resistant Helicobacter pylori With Narrow‐Spectrum Activity

Advanced Science, EarlyView.
Carnosic acid selectively eradicates drug‐resistant Helicobacter pylori through a multi‐targeted mechanism involving urease inhibition, membrane disruption, and biofilm eradication. It exhibits no detectable resistance, potent in vivo efficacy, and minimal impact on gut microbiota, positioning it as a promising narrow‐spectrum lead compound against ...
Yuefan Bai, Hongming Huang, Xudong Hang, Shanwei Hu, Qian Tong, Jingchen Xu, Jia Jia, Hongkai Bi   +7 more
wiley   +1 more source

Variability of Daptomycin MIC Values for Enterococcus faecium When Measured by Reference Broth Microdilution and Gradient Diffusion Tests

Antimicrobial Agents and Chemotherapy, 2018
Daptomycin has become a mainstay therapy for the treatment of serious vancomycin-resistant Enterococcus faecium infections. However, concern exists that current testing methods do not accurately predict the clinical success of daptomycin therapy ...
S. Campeau, A. Schuetz, P. Kohner, C. Arias, P. Hemarajata, J. Bard, R. Humphries   +6 more
semanticscholar   +1 more source

Multisite Reproducibility of the Broth Microdilution Method for Susceptibility Testing of Nocardia Species [PDF]

Journal of Clinical Microbiology, 2012
ABSTRACT Antimicrobial susceptibility testing (AST) of clinical isolates of Nocardia is recommended to detect resistance to commonly used antimicrobial agents; such testing is complicated by difficulties in inoculum preparation and test interpretation.
Patricia S, Conville, Barbara A, Brown-Elliott, Richard J, Wallace, Frank G, Witebsky, Deloris, Koziol, Geraldine S, Hall, Scott B, Killian, Cindy C, Knapp, David, Warshauer, Tam, Van, Nancy L, Wengenack, Sharon, Deml, Gail L, Woods   +12 more
openaire   +2 more sources

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Recommendation for a Standardised Method of Broth Microdilution Susceptibility Testing for Porcine Bordetella bronchiseptica. [PDF]

PLoS ONE, 2015
The objective was to establish and standardise a broth microdilution susceptibility testing method for porcine Bordetella (B.) bronchiseptica. B. bronchiseptica isolates from different geographical regions and farms were genotyped by macrorestriction ...
Sandra Prüller, Cornelia Frömke, Heike Kaspar, Günter Klein, Lothar Kreienbrock, Corinna Kehrenberg   +5 more
doaj   +1 more source

Calcineurin‐Dependent Stress Adaptation Enables Caspofungin Heteroresistance Leading to Stable Resistance in Candida Glabrata

Advanced Science, EarlyView.
Caspofungin heteroresistance is prevalent in clinical Candida glabrata isolates and depends on calcineurin‐mediated stress adaptation. This transient phenotype serves as a reservoir for resistance evolution, enabling the emergence of stable resistant descendants under prolonged drug pressure.
Yanyu Su, Yi Li, Meng Xiao, Dan Guo, David S. Perlin, Erika Shor, Yingchun Xu, Yingxing Li   +7 more
wiley   +1 more source

Analysis of antibiotic sensitivity of clinical strains of microorganisms with the Russian Mueller–Hinton broth

Журнал микробиологии, эпидемиологии и иммунобиологии
Introduction. One of the reasons for spreading antibiotic-resistant microorganisms is the uncontrolled use and inadequate empirical prescription of antibiotics which is not based on the results of the pathogen sensitivity testing.
Irina S. Kosilova, Lyubov V. Domotenko, Mikhail V. Khramov   +2 more
doaj   +1 more source

Guidelines for Detecting the Foodborne Antibiotic‐Resistant Bacteria

AgriFood: Journal of Agricultural Products for Food, EarlyView.
ABSTRACT Foodborne antibiotic‐resistant bacteria threaten global public health and the economic. Standardized detection methods are crucial for effective prevention and control. Researchers encounter difficulties in choosing suitable techniques due to the variety of available approaches and the intricate nature of resistance mechanisms.
Yuanye Zeng, Fengxia Yang
wiley   +1 more source

Antimicrobial susceptibility testing by broth microdilution method: widely available modification [PDF]

Клиническая микробиология и антимикробная химиотерапия, 2018
Objective. To assess the possibility of standard disk application as an antibiotic source for determination of the minimal inhibitory concentrations (MICs) by serial microdilution method. Materials and Methods.
Tapalskiy D.V., Bilskiy I.A.
doaj