Results 101 to 110 of about 1,154,949 (367)

HOXC10 suppresses browning to maintain white adipocyte identity

Diabetes, 2021
Promoting beige adipocyte development within white adipose tissue (WAT) is a potential therapeutic approach to staunch the current obesity epidemic. Previously, we identified homeobox-containing transcription factor HOXC10 as a suppressor of browning in subcutaneous WAT.
H.Y. Angeline Tan, M.F. Michelle Sim, Shi-Xiong Tan, Yvonne Ng, Sin Yee Gan, Hongyu Li, Suat Peng Neo, Jayantha Gunaratne, Feng Xu, Weiping Han   +9 more
openaire   +4 more sources

BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis

Redox Biology, 2021
Loss of perivascular adipose tissue (PVAT) impairs endothelial function and enhances atherosclerosis. However, the roles of PVAT thermoregulation in vascular inflammation and the development of atherosclerosis remains unclear.
Wenjuan Mu, Shuwen Qian, Yanjue Song, Lijie Yang, Saisai Song, Qiqi Yang, Hao Liu, Yang Liu, Dongning Pan, Yan Tang, Qi-Qun Tang   +10 more
doaj   +1 more source

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

EBF2 Determines and Maintains Brown Adipocyte Identity [PDF]

Cell Metabolism, 2013
The master transcription factor Pparγ regulates the general differentiation program of both brown and white adipocytes. However, it has been unclear whether Pparγ also controls fat lineage-specific characteristics. Here, we show that early B cell factor-2 (Ebf2) regulates Pparγ binding activity to determine brown versus white adipocyte identity.
Rajakumari, Sona, Wu, Jun, Ishibashi, Jeff, Lim, Hee-Woong, Giang, An-Hoa, Won, Kyoung-Jae, Reed, Randall R., Seale, Patrick   +7 more
openaire   +2 more sources

Single-nucleus mRNA-sequencing reveals dynamics of lipogenic and thermogenic adipocyte populations in murine brown adipose tissue in response to cold exposure

Molecular Metabolism
Objective and methods: Brown adipose tissue (BAT) comprises a heterogeneous population of adipocytes and non-adipocyte cell types. To characterize these cellular subpopulations and their adaptation to cold, we performed single-nucleus mRNA-sequencing ...
Janina Behrens, Tongtong Wang, Christoph Kilian, Anna Worthmann, Mark A. Herman, Joerg Heeren, Lorenz Adlung, Ludger Scheja   +7 more
doaj   +1 more source

A Cold Stress‐Activated Endocrine Sentinel Chemical Hormone Promotes Insect Survival via Mitochondrial Adaptations Through the Adipokinetic Hormone Receptor

Advanced Science, EarlyView.
Seasonal cold adaptation is vital for insect survival, yet the molecular mechanisms linking diapause to mitochondrial resilience remain largely unresolved. We identify ascaroside C9 (asc‐C9) as a key endocrine signal that enhances diapause survival during cold stress by activating the AKHR–PGC1α–UCP4 axis, thereby driving cold‐induced lipolysis and ...
Jiao Zhou, Junxian Chen, Hongxia Zhang, Lu Guo, Kevin Mai, Elijah Abraham, Dilip V. Prajapati, Yue Chang, Jing Ning, Xinchen Wang, Defeng Li, Dan‐Dan Zhang, Jianghua Sun, Rebecca A. Butcher, Lilin Zhao   +14 more
wiley   +1 more source

Pyruvate dehydrogenase complex plays a central role in brown adipocyte energy expenditure and fuel utilization during short-term beta-adrenergic activation

Scientific Reports, 2018
Activation of brown adipose tissue (BAT) contributes to total body energy expenditure through energy dissipation as heat. Activated BAT increases the clearance of lipids and glucose from the circulation, but how BAT accommodates large influx of multiple ...
N. Held, Eline N. Kuipers, Michel van Weeghel, J. V. van Klinken, S. Denis, M. Lombès, R. Wanders, F. Vaz, P. Rensen, A. Verhoeven, M. Boon, R. Houtkooper   +11 more
semanticscholar   +1 more source

The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes

Journal of Lipid Research, 2012
White and brown adipocytes are believed to occupy different sites in the body. We studied the anatomical features and quantitative histology of the fat depots in obesity and type 2 diabetes-prone C57BL/6J mice acclimated to warm or cold temperatures ...
A. Vitali, I. Murano, M.C. Zingaretti, A. Frontini, D. Ricquier, S. Cinti   +5 more
doaj   +1 more source

Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ

Frontiers in Cell and Developmental Biology, 2021
Aging-associated chronic inflammation is a key contributing factor to a cluster of chronic metabolic disorders, such as cardiovascular disease, obesity, and type 2 diabetes.
Xiao-Xi Pan, Kang-Li Yao, Yong-Feng Yang, Qian Ge, Run Zhang, Ping-Jin Gao, Cheng-Chao Ruan, Fang Wu   +7 more
doaj   +1 more source

Functional Implications of DNA Methylation in Adipose Biology. [PDF]

, 2019
The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic issue. The dysregulation of adipose tissue biology is central to the development of these two metabolic disorders, as adipose tissue plays a pivotal role ...
Kang, Sona, Ma, Xiang
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