Molecular MetabolismObjective and methods: Brown adipose tissue (BAT) comprises a heterogeneous population of adipocytes and non-adipocyte cell types. To characterize these cellular subpopulations and their adaptation to cold, we performed single-nucleus mRNA-sequencing ...
Janina Behrens +7 more
doaj +1 more source
Single cell analysis reveals immune cell-adipocyte crosstalk regulating the transcription of thermogenic adipocytes. [PDF]
, 2019 Immune cells are vital constituents of the adipose microenvironment that influence both local and systemic lipid metabolism. Mice lacking IL10 have enhanced thermogenesis, but the roles of specific cell types in the metabolic response to IL10 remain to ...
Ahn, In Sook +15 more
core +1 more source
Role of arginase 2 in systemic metabolic activity and adipose tissue fatty acid metabolism in diet-induced obese mice [PDF]
, 2019 Visceral adipose tissue (VAT) inflammation and metabolic dysregulation are key components of obesity-induced metabolic disease. Upregulated arginase, a ureahydrolase enzyme with two isoforms (A1-cytosolic and A2-mitochondrial), is implicated in ...
Atawia, Reem T +8 more
core +2 more sources
The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes
Journal of Lipid Research, 2012 White and brown adipocytes are believed to occupy different sites in the body. We studied the anatomical features and quantitative histology of the fat depots in obesity and type 2 diabetes-prone C57BL/6J mice acclimated to warm or cold temperatures ...
A. Vitali +5 more
doaj +1 more source
Senescent T Cell Induces Brown Adipose Tissue “Whitening” Via Secreting IFN-γ
Frontiers in Cell and Developmental Biology, 2021 Aging-associated chronic inflammation is a key contributing factor to a cluster of chronic metabolic disorders, such as cardiovascular disease, obesity, and type 2 diabetes.
Xiao-Xi Pan +7 more
doaj +1 more source
The pharmacology and function of receptors for short-chain fatty acids [PDF]
, 2015 Despite some blockbuster G protein–coupled receptor (GPCR) drugs, only a small fraction (∼15%) of the more than 390 nonodorant GPCRs have been successfully targeted by the pharmaceutical industry.
Bolognini, Daniele +3 more
core +1 more source
Tumor necrosis factor α mediates apoptosis of brown adipocytes and defective brown adipocyte function in obesity [PDF]
Proceedings of the National Academy of Sciences, 2000 Severe quantitative and qualitative brown adipocyte defects are common in obesity. To investigate whether aberrant expression of tumor necrosis factor α (TNF-α) in obesity is involved in functional brown fat atrophy, we have studied genetically obese ( ob / ob ) mice with targeted null ...
Antonio Giordano +8 more
openaire +2 more sources
Stem Cell Research & Therapy, 2019 Background The role of brown fat in non-shivering thermogenesis and the discovery of brown fat depots in adult humans has made it the subject of intense research interest.
Michael D. West +14 more
doaj +1 more source
Functional Implications of DNA Methylation in Adipose Biology. [PDF]
, 2019 The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic issue. The dysregulation of adipose tissue biology is central to the development of these two metabolic disorders, as adipose tissue plays a pivotal role ...
Kang, Sona, Ma, Xiang
core
Perivascular adipose tissue as a relevant fat depot for cardiovascular risk in obesity [PDF]
, 2018 Obesity is associated with increased risk of premature death, morbidity, and mortality from several cardiovascular diseases (CVDs), including stroke, coronary heart disease (CHD), myocardial infarction, and congestive heart failure.
Costa, Rafael M. +3 more
core +3 more sources