Results 171 to 180 of about 28,025 (237)

Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes (Diabetes Metab J 2024;48:885-900). [PDF]

Diabetes Metab J
Gu J, Zhang X, Zhang Q, Wang Z.
europepmc   +2 more sources

Hypoxia Regulates Brown Adipocyte Differentiation and Stimulates miR-210 by HIF-1α. [PDF]

Int J Mol Sci
Caca J, Bartelt A, Egea V.
europepmc   +1 more source

ASK1‐Induced FGF21 Synthesis in the Liver Prevents Obesity in Mice

Obesity, Volume 34, Issue 8, Page 1635-1646, August 2026.
ABSTRACT Objective Fibroblast growth factor 21 (FGF21) is a stress‐induced hormone secreted by the liver. It has a beneficial role in the regulation of glucose and energy metabolism. Herein, we identify apoptosis signal regulating kinase 1 (ASK1) as an inducer of hepatic FGF21 synthesis.
Anne Goergen, Tenagne D. Challa, Carlos Villaroel‐Vicente, Marcela Borsigova, Pim P. van Krieken, Christian Wolfrum, Matthias Blüher, Stephan Wueest, Daniel Konrad   +8 more
wiley   +1 more source

Brown adipocyte exosome - derived C22:6 inhibits the IL-1β signaling pathway to alleviate rheumatoid arthritis. [PDF]

Front Immunol
Jiang R, Huang Y, Ye R, Zhang Y, Dong M, Zhang H, Cheng Z, Zhang Z, Zhang J, Zhang Q, Sun G, Jin W.   +11 more
europepmc   +1 more source

Secreted frizzled-related protein 4 promotes brown adipocyte differentiation. [PDF]

Exp Ther Med, 2021
Guan H, Zheng H, Zhang J, Xiang A, Li Y, Zheng H, Xu L, Liu E, Yu Q.   +8 more
europepmc   +1 more source

Human Islet miR‐199a‐5p and miR‐214‐3p Associate With Donor Age, BMI, and Sex and Mediate Cellular Aging in Islet‐Derived Cells

Acta Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Objectives Human islets are widely researched to understand pathophysiological mechanisms leading to diabetes. Sex, age, and body mass index (BMI) are key donor traits influencing islet function, which is also regulated by an intricate network of microRNAs.
Wilson K. M. Wong, Isabelle El‐Azzi, Aditya Nachanekar, Ehsan Alvandi, Nhan Ho Trong Pham, Hrishikesh P. Hardikar, Mya Polkamp, Vijit Saini, Feifei Cheng, Guozhi Jiang, Anja E. Sørensen, Yi Vee Chew, Helen E. Thomas, Thomas Loudovaris, Ronald C. W. Ma, Wayne J. Hawthorne, Louise T. Dalgaard, Mugdha V. Joglekar, Anandwardhan A. Hardikar   +18 more
wiley   +1 more source

Brown adipocyte-derived exosomes in type 2 diabetes mellitus impair endothelial function via regulating intracellular calcium cycle. [PDF]

Front Cardiovasc Med
Ruan X, Zhao W.
europepmc   +1 more source

Jiuwei Xiaozhi Decoction Alleviates High‐Fat Diet‐Induced MASLD by Suppressing Hepatic SREBP2‐Driven Cholesterogenesis and Restoring PPARα‐Mediated Fatty Acid Oxidation

Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.
Studies have found that Jiuwei Xiaozhi Decoction can improve high‐fat diet‐induced fatty liver disease, mainly by regulating the SREBP2 and PPARα pathways to balance hepatic lipid metabolism while reducing inflammatory responses. ABSTRACT Jiuwei Xiaozhi Decoction (JWXZ) is a nine‐herb traditional Chinese medicine formula clinically used for hepatic ...
Youcheng Ma, Xinrui Gao, Ji Wang, Lingru Li, Zhen Huang, Fangli Li   +5 more
wiley   +1 more source

GIP in Cardiovascular and Kidney Disease: From Physiology to Pharmacology

Diabetes, Obesity and Metabolism, Volume 28, Issue 8, Page 6509-6532, August 2026.
ABSTRACT Aims To provide a comprehensive overview of the cardiovascular and renal effects of glucose‐dependent insulinotropic polypeptide (GIP) by integrating its physiological role with recent human trial data on tirzepatide, the first dual GIP and glucagon‐like peptide‐1 (GLP‐1) receptor agonist.
Michelantonio De Fano, Line L. Haurum, Christine R. Schwarz, Francesca Porcellati, Andreas Andersen   +4 more
wiley   +1 more source

Obesity and pony breed are associated with plasma L‐lactate in horses with acute gastrointestinal disease

Equine Veterinary Education, Volume 38, Issue 8, Page e516-e522, August 2026.
Summary Background Plasma L‐lactate (lactate) is widely used as a prognostic marker in horses with acute gastrointestinal disease (colic), but association with obesity is unclear. In humans, plasma lactate is correlated with obesity and insulin resistance. Objectives This study aims to evaluate the association of obesity (body condition score ≥7/9) and
A. L. Tillisch, C. Frørup, M. B. Petersen, S. Jacobsen, T. H. Pihl   +4 more
wiley   +1 more source