Stress-inducible IL-6 is regulated by KLF7 in brown adipocytes [PDF]
Heliyon, 2023 Stress-inducible interleukin 6 (IL-6) is generated in brown adipocytes via beta-3 adrenergic receptor (ADRB3) signaling, which is necessary in stress hyperglycemia, the kind of metabolic adaptation enabling “fight or flight” response by means of liver ...
Menghuan Li, Yanting Hou
exaly +4 more sources
Regulation of glycolysis in brown adipocytes by HIF-1α [PDF]
Scientific Reports, 2017 Brown adipose tissue takes up large amounts of glucose during cold exposure in mice and humans. Here we report an induction of glucose transporter 1 expression and increased expression of several glycolytic enzymes in brown adipose tissue from cold ...
Astrid L. Basse +9 more
doaj +10 more sources
Effects of glucocorticoids on human brown adipocytes [PDF]
Journal of Endocrinology, 2014 Clinical cases of glucocorticoid (GC) excess are characterized by increased fat mass and obesity through the accumulation of white adipocytes. The effects of GCs on growth and function of brown adipose tissue are unknown and may contribute to the negative energy balance observed clinically. This study aims to evaluate the effect of GCs on proliferation,
Barclay, Johanna L. +5 more
openaire +7 more sources
Mitochondria in White, Brown, and Beige Adipocytes [PDF]
Stem Cells International, 2016 Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the beige/brite/brown‐like (bAT) adipose tissues.
Miroslava Cedikova +7 more
openaire +5 more sources
PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes [PDF]
Molecular Metabolism, 2022 Objective: Brown adipocytes play a key role in maintaining body temperature as well as glucose and lipid homeostasis. However, brown adipocytes need to adapt their thermogenic activity and substrate utilization to changes in nutrient availability ...
Jiefu Wang +9 more
doaj +2 more sources
Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses [PDF]
Mediators of Inflammation, 2017 Obesity is marked by chronic, low-grade inflammation. Here, we examined whether intrinsic differences between white and brown adipocytes influence the inflammatory status of macrophages.
Louisa Dowal +13 more
doaj +2 more sources
Recent insights into the molecular mechanisms of simultaneous fatty acid oxidation and synthesis in brown adipocytes [PDF]
Frontiers in Endocrinology, 2023 Brown adipocytes is a specialized fat cell that dissipates nutrient-derived chemical energy in the form of heat, instead of ATP synthesis. This unique feature provides a marked capacity for brown adipocyte mitochondria to oxidize substrates independent ...
Ji Suk Chang
doaj +3 more sources
Direct Evidence of Brown Adipocytes in Different Fat Depots in Children
PLoS ONE, 2015 Recent studies suggested the persistence of brown adipocytes in adult humans, as opposed to being exclusively present in infancy. In this study, we investigated the presence of brown-like adipocytes in adipose tissue (AT) samples of children and ...
Antje Körner +2 more
exaly +3 more sources
Sphingosine kinase 1 is involved in triglyceride breakdown by maintaining lysosomal integrity in brown adipocytes [PDF]
Journal of Lipid Research, 2023 Sphingosine 1-phosphate (S1P) has been implicated in brown adipose tissue (BAT) formation and energy consumption; however, the mechanistic role of sphingolipids, including S1P, in BAT remains unclear. Here, we showed that, in mice, BAT activation by cold
Jun-ichi Morishige +7 more
doaj +2 more sources
A Genetic Model to Study the Contribution of Brown and Brite Adipocytes to Metabolism
Cell Reports, 2020 Summary: UCP1-dependent thermogenesis is studied to define new strategies to ameliorate obesity and type 2 diabetes; however, animal models are mostly limited to germline mutations of UCP1, which can effect adaptive changes in UCP1-independent pathways ...
Wenfei Sun +2 more
exaly +3 more sources