Results 11 to 20 of about 1,446,812 (280)
Effects of glucocorticoids on human brown adipocytes [PDF]
Journal of Endocrinology, 2014 Clinical cases of glucocorticoid (GC) excess are characterized by increased fat mass and obesity through the accumulation of white adipocytes. The effects of GCs on growth and function of brown adipose tissue are unknown and may contribute to the negative energy balance observed clinically. This study aims to evaluate the effect of
Barclay, Johanna L. +5 more
openaire +6 more sources
Mitochondria in White, Brown, and Beige Adipocytes [PDF]
Stem Cells International, 2016 Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the beige/brite/brown‐like (bAT) adipose tissues.
Miroslava Cedikova +7 more
openaire +5 more sources
PAT2 regulates vATPase assembly and lysosomal acidification in brown adipocytes
Molecular Metabolism, 2022 Objective: Brown adipocytes play a key role in maintaining body temperature as well as glucose and lipid homeostasis. However, brown adipocytes need to adapt their thermogenic activity and substrate utilization to changes in nutrient availability ...
Jiefu Wang +9 more
doaj +2 more sources
Regulation of glycolysis in brown adipocytes by HIF-1α [PDF]
Scientific Reports, 2017 Brown adipose tissue takes up large amounts of glucose during cold exposure in mice and humans. Here we report an induction of glucose transporter 1 expression and increased expression of several glycolytic enzymes in brown adipose tissue from cold ...
Astrid L. Basse +9 more
doaj +2 more sources
Intrinsic Properties of Brown and White Adipocytes Have Differential Effects on Macrophage Inflammatory Responses [PDF]
Mediators of Inflammation, 2017 Obesity is marked by chronic, low-grade inflammation. Here, we examined whether intrinsic differences between white and brown adipocytes influence the inflammatory status of macrophages.
Louisa Dowal +13 more
doaj +2 more sources
Recent insights into the molecular mechanisms of simultaneous fatty acid oxidation and synthesis in brown adipocytes [PDF]
Frontiers in Endocrinology, 2023 Brown adipocytes is a specialized fat cell that dissipates nutrient-derived chemical energy in the form of heat, instead of ATP synthesis. This unique feature provides a marked capacity for brown adipocyte mitochondria to oxidize substrates independent ...
Ji Suk Chang
doaj +2 more sources
Optogenetic activation of UCP1-dependent thermogenesis in brown adipocytes. [PDF]
iScience, 2023 Summary: Brown adipocytes are unique in that they expend energy and produce heat to maintain euthermia through expression of uncoupling protein-1 (UCP1).
Doucette CC +9 more
europepmc +4 more sources
Journal of Lipid Research, 1994 Brown adipose tissue and collagenase-isolated brown adipocytes were investigated in rats by means of 1H and 13C nuclear magnetic resonance spectroscopy.
C Zancanaro +5 more
doaj +2 more sources
Cell Metabolism, 2010 We are pleased to present in this issue of Cell Metabolism a review series on brown adipocytes. Until recently, brown adipose tissue (BAT) was principally studied by a handful of investigators focused on rodents and newborn mammals, and, at times, their work was deemed more an exercise in scientific curiosity than an issue relevant to human health.
Emambokus, Nikla, Wang, Charlotte
openaire +2 more sources
Compartmentalisation of cAMP in Brown Adipocytes [PDF]
, 2022 The second messenger, 3',5'-cyclic adenosine monophosphate (cAMP) plays an important role in governing the function and differentiation of brown adipocytes.
Arcot Kannabiran, Sukanya
core +1 more source