Results 11 to 20 of about 39,242 (266)

Differentiation of human adipose-derived stem cells into brite (brown-in-white) adipocytes [PDF]

Frontiers in Endocrinology, 2011
It is well established now that adult humans possess active brown adipose tissue which represents a potential pharmacological target to combat obesity and associated diseases.
Didier F Pisani, Mansour eDjedaini, Guillaume E Beranger, Christian eElabd, Marcel eScheideler, Gerard P Ailhaud, Ez-Zoubir eAmri   +6 more
doaj   +2 more sources

Brown adipocytes can display a mammary basal myoepithelial cell phenotype in vivo

Molecular Metabolism, 2017
Objective: Previous work has suggested that white adipocytes may also show a mammary luminal secretory cell phenotype during lactation. The capacity of brown and beige/brite adipocytes to display a mammary cell phenotype and the levels at which they ...
Speakman John, , Elżbieta Król
exaly   +3 more sources

Commitment of adipose-resident c-kit+ progenitors to brown adipocytes contributes to adipose tissue homeostasis and remodeling [PDF]

Nature Communications
The global incidence of obesity-related metabolic disorders and their comorbidities continue to increase along with a demand for innovative therapeutic interventions.
Qishan Chen, Ya Yu, Run Zhang, Qiaohang Zhao, Danqing Yu, Chun Feng, Jiaojiao Zhou, Meng Luo, Mei Yang, ShaSha Sun, Li Zhang, Min Jin   +11 more
doaj   +2 more sources

Magnetic resonance spectroscopy investigations of brown adipose tissue and isolated brown adipocytes. [PDF]

Journal of Lipid Research, 1994
Brown adipose tissue and collagenase-isolated brown adipocytes were investigated in rats by means of 1H and 13C nuclear magnetic resonance spectroscopy.
C Zancanaro, R Nano, C Marchioro, A Sbarbati, A Boicelli, F Osculati   +5 more
doaj   +2 more sources

Optogenetic activation of UCP1-dependent thermogenesis in brown adipocytes. [PDF]

iScience, 2023
Summary: Brown adipocytes are unique in that they expend energy and produce heat to maintain euthermia through expression of uncoupling protein-1 (UCP1).
Doucette CC, Nguyen DC, Barteselli D, Blanchard S, Pelletier M, Kesharwani D, Jachimowicz E, Su S, Karolak M, Brown AC.   +9 more
europepmc   +4 more sources

Defective insulin-stimulated GLUT4 translocation in brown adipocytes induces systemic glucose homeostasis dysregulation independent of thermogenesis in female mice

Molecular Metabolism, 2021
Objective: Recent studies indicate that brown adipose tissue, in addition to its role in thermogenesis, has a role in the regulation of whole-body metabolism.
Belén Picatoste, Lucie Yammine, Rosemary A. Leahey, David Soares, Emma F. Johnson, Paul Cohen, Timothy E. McGraw   +6 more
doaj   +1 more source

Supraclavicular brown adipocytes originate from Tbx1+ myoprogenitors. [PDF]

PLoS Biol, 2023
Brown adipose tissue (BAT) dissipates energy as heat, contributing to temperature control, energy expenditure, and systemic homeostasis. In adult humans, BAT mainly exists in supraclavicular areas and its prevalence is associated with cardiometabolic ...
Huang Z, Gu C, Zhang Z, Arianti R, Swaminathan A, Tran K, Battist A, Kristóf E, Ruan HB.   +8 more
europepmc   +2 more sources

Adipocytes and Stromal Cells Regulate Brown Adipogenesis Through Secretory Factors During the Postnatal White-to-Brown Conversion of Adipose Tissue in Syrian Hamsters

Frontiers in Cell and Developmental Biology, 2021
Brown adipose tissue (BAT) is a specialized tissue that regulates non-shivering thermogenesis. In Syrian hamsters, interscapular adipose tissue is composed primarily of white adipocytes at birth, which is converted to BAT through the proliferation and ...
Junnosuke Mae, Kazuki Nagaya, Yuko Okamatsu-Ogura, Ayumi Tsubota, Shinya Matsuoka, Junko Nio-Kobayashi, Kazuhiro Kimura   +6 more
doaj   +1 more source

Thermogenic ability of uncoupling protein 1 in beige adipocytes in mice. [PDF]

PLoS ONE, 2013
Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adipose tissue in mice. Despite their morphological similarities to brown adipocytes and their expression of uncoupling protein 1 (UCP1), a thermogenic ...
Yuko Okamatsu-Ogura, Keigo Fukano, Ayumi Tsubota, Akihiro Uozumi, Akira Terao, Kazuhiro Kimura, Masayuki Saito   +6 more
doaj   +1 more source

Brown Adipocyte Focus [PDF]

Cell Metabolism, 2010
We are pleased to present in this issue of Cell Metabolism a review series on brown adipocytes. Until recently, brown adipose tissue (BAT) was principally studied by a handful of investigators focused on rodents and newborn mammals, and, at times, their work was deemed more an exercise in scientific curiosity than an issue relevant to human health.
Emambokus, Nikla, Wang, Charlotte
openaire   +2 more sources