Results 21 to 30 of about 1,446,812 (280)

NF-κB regulates brown adipocyte function through suppression of ANT2

Acta Pharmaceutica Sinica B, 2022
The transcription factor nuclear factor of kappa-light-chain-enhancer of activated B cells (NF-κB) is expressed in brown adipocytes, but its role remains largely unknown in the cells.
Shiqiao Peng, Xiaoying Zhang, Lili Yu, Yanhong Xu, Yang Zhou, Shengnan Qian, Xinyu Cao, Xiaotong Ye, Jiajun Yang, Weiping Jia, Jianping Ye   +10 more
doaj   +1 more source

TFAM expression in brown adipocytes confers obesity resistance by secreting extracellular vesicles that promote self-activation

iScience, 2022
Summary: The occurrence of diet-induced obesity has been increasing worldwide and has become a major health concern. Mitochondria are densely distributed in brown adipose tissue and are involved in lipid consumption.
Masakazu Fujii, Daiki Setoyama, Kazuhito Gotoh, Yushi Dozono, Mikako Yagi, Masataka Ikeda, Tomomi Ide, Takeshi Uchiumi, Dongchon Kang   +8 more
doaj   +1 more source

Src family kinases suppress differentiation of brown adipocytes and browning of white adipocytes [PDF]

Genes to Cells, 2016
Brown adipocytes and beige adipocytes can expend energy, generate heat, and increase whole‐body energy expenditure. The detailed mechanisms of adipogenesis and thermogenesis of these cells are still obscure. Here, we show that Src family kinases (SFKs) regulate both brown adipogenesis and browning of white adipocytes.
Mai, Usui, Masaharu, Uno, Eisuke, Nishida   +2 more
openaire   +2 more sources

A Method to Induce Brown/Beige Adipocyte Differentiation from Murine Preadipocytes

Bio-Protocol, 2021
Adipocytes exhibit different morphological and functional characteristics, depending on their anatomical location, developmental origin, and stimulus. While white adipocytes tend to accumulate energy as triglycerides, brown and beige adipocytes tend to ...
Andréa Rocha, Beatriz Guerra, Jeremie Boucher, Marcelo Mori   +3 more
doaj   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Supraclavicular brown adipocytes originate from Tbx1+ myoprogenitors. [PDF]

PLoS Biol, 2023
Brown adipose tissue (BAT) dissipates energy as heat, contributing to temperature control, energy expenditure, and systemic homeostasis. In adult humans, BAT mainly exists in supraclavicular areas and its prevalence is associated with cardiometabolic ...
Huang Z, Gu C, Zhang Z, Arianti R, Swaminathan A, Tran K, Battist A, Kristóf E, Ruan HB.   +8 more
europepmc   +2 more sources

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Brown adipogenic potential of brown adipocytes and peri-renal adipocytes from human embryo [PDF]

Scientific Reports, 2016
AbstractBoth brown adipocytes (BAC) and beige cells hold therapeutic potential for the treatment of metabolic disorders. Unfortunately, the amount and activity of these cells are limited in adults. Although BAC marker expression has been shown in peri-renal adipose tissues in children and adults, functional assessment is lacking.
Nan-Nan Wu, Chuan-Hai Zhang, Hyuek-Jong Lee, Yan Ma, Xin Wang, Xiao-Juan Ma, Wei Ma, Dong Zhao, Ying-Mei Feng   +8 more
openaire   +2 more sources

Epigenetic Regulators of White Adipocyte Browning [PDF]

Epigenomes, 2021
Adipocytes play an essential role in maintaining energy homeostasis in mammals. The primary function of white adipose tissue (WAT) is to store energy; for brown adipose tissue (BAT), primary function is to release fats in the form of heat. Dysfunctional or excess WAT can induce metabolic disorders such as dyslipidemia, obesity, and diabetes ...
openaire   +3 more sources

Lipid Transport in Brown Adipocyte Thermogenesis [PDF]

Frontiers in Physiology, 2021
Non-shivering thermogenesis is an energy demanding process that primarily occurs in brown and beige adipose tissue. Beyond regulating body temperature, these thermogenic adipocytes regulate systemic glucose and lipid homeostasis. Historically, research on thermogenic adipocytes has focused on glycolytic metabolism due to the discovery of active brown ...
Gina Wade, Ayren McGahee, James M. Ntambi, Judith Simcox   +3 more
openaire   +3 more sources