Results 31 to 40 of about 39,242 (266)
Lipid Transport in Brown Adipocyte Thermogenesis [PDF]
Frontiers in Physiology, 2021 Non-shivering thermogenesis is an energy demanding process that primarily occurs in brown and beige adipose tissue. Beyond regulating body temperature, these thermogenic adipocytes regulate systemic glucose and lipid homeostasis. Historically, research on thermogenic adipocytes has focused on glycolytic metabolism due to the discovery of active brown ...
Gina Wade +3 more
openaire +3 more sources
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes [PDF]
Journal of Biological Chemistry, 2015 Brown adipose tissue expends energy in the form of heat via the mitochondrial uncoupling protein UCP1. Recent studies showed that brown adipose tissue is present in adult humans and may be exploited for its anti-obesity and anti-diabetes actions. Apelin is an adipocyte-derived hormone that plays important roles in energy metabolism.
Than A. +6 more
openaire +3 more sources
A Method to Induce Brown/Beige Adipocyte Differentiation from Murine Preadipocytes
Bio-Protocol, 2021 Adipocytes exhibit different morphological and functional characteristics, depending on their anatomical location, developmental origin, and stimulus. While white adipocytes tend to accumulate energy as triglycerides, brown and beige adipocytes tend to ...
Andréa Rocha +3 more
doaj +1 more source
Lithium inhibits brown adipocyte differentiation [PDF]
FEBS Letters, 2005 Lithium impairs the appearance of the characteristic morphology of brown adipocytes and downregulates the expression of marker genes of brown adipocyte differentiation. These effects are dose‐dependent and are more pronounced when exposure of preadipocytes to lithium is initiated at early stages of differentiation.
Rodrı́guez de la Concepción, Maria Luisa +4 more
openaire +2 more sources
Hepatology, EarlyView., 2022 Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo +14 more
wiley +1 more source
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
Role of Ubiquilins for Brown Adipocyte Proteostasis and Thermogenesis [PDF]
Frontiers in Endocrinology, 2021 The acclimatization of brown adipose tissue (BAT) to sustained cold exposure requires an adaptive increase in proteasomal protein quality control. Ubiquilins represent a recently identified family of shuttle proteins with versatile functions in protein degradation, such as facilitating substrate targeting and proteasomal degradation.
Carolin Muley +5 more
openaire +5 more sources
The Therapeutic Potential of Brown Adipocytes in Humans [PDF]
Frontiers in Endocrinology, 2015 Obesity and its metabolic consequences represent a significant clinical problem. From a thermodynamic standpoint, obesity results from a discord in energy intake and expenditure. To date, lifestyle interventions based on reducing energy intake and/or increasing energy expenditure have proved ineffective in the prevention and/or treatment of obesity ...
Craig ePorter +6 more
openaire +5 more sources
Importance of adipocyte browning in the evolution of endothermy [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2020 Endothermy changes the relationship between organisms and their environment fundamentally, and it is therefore of major ecological and evolutionary significance. Endothermy is characterized by non-shivering thermogenesis, that is metabolic heat production in the absence of muscular activity.
Martin Jastroch, Frank Seebacher
openaire +2 more sources
RIP140 represses the “Brown-in-White” adipocyte program including a futile cycle of triacyclglycerol breakdown and synthesis [PDF]
, 2014 Receptor-interacting protein 140 (RIP140) is a corepressor of nuclear receptors that is highly expressed in adipose tissues. We investigated the role of RIP140 in conditionally immortal preadipocyte cell lines prepared from white or brown fat depots.
Edward Curry +25 more
core +1 more source