Results 31 to 40 of about 1,446,812 (280)
Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes [PDF]
Journal of Biological Chemistry, 2015 Brown adipose tissue expends energy in the form of heat via the mitochondrial uncoupling protein UCP1. Recent studies showed that brown adipose tissue is present in adult humans and may be exploited for its anti-obesity and anti-diabetes actions. Apelin is an adipocyte-derived hormone that plays important roles in energy metabolism.
Than A. +6 more
openaire +3 more sources
Frontiers in Physiology, 2021 The mammalian target of rapamycin (mTOR) is an important protein kinase that senses changes in extracellular and intracellular energy levels and plays a key role in regulating energy metabolism.
Bahetiyaer Huwatibieke +10 more
doaj +1 more source
RIP140 represses the “Brown-in-White” adipocyte program including a futile cycle of triacyclglycerol breakdown and synthesis [PDF]
, 2014 Receptor-interacting protein 140 (RIP140) is a corepressor of nuclear receptors that is highly expressed in adipose tissues. We investigated the role of RIP140 in conditionally immortal preadipocyte cell lines prepared from white or brown fat depots.
Edward Curry +25 more
core +1 more source
Transcriptional fingerprinting of "browning" white fat identifies NRG4 as a novel adipokine [PDF]
, 2014 Brown adipocytes help to maintain body temperature by the expression of a unique set of genes that facilitate cellular metabolic events including uncoupling protein 1-dependent thermogenesis.
Christian, Mark, Christian, M
core +1 more source
Full activation of thermogenesis in brown adipocytes requires Basigin action
, 2023 Exploring mechanisms responsible for brown adipose tissue's (BAT) high metabolic activity is crucial to exploit its energy-dissipating ability for therapeutic purposes.
Hansen, Jacob B +40 more
core +1 more source
Short-chain fatty acid acetate stimulates adipogenesis and mitochondrial biogenesis via GPR43 in brown adipocytes [PDF]
, 2016 Short-chain fatty acids play crucial roles in a range of physiological functions. However, the effects of short-chain fatty acids on brown adipose tissue have not been fully investigated.
GK Dimitriadis (7772033) +45 more
core +1 more source
Importance of adipocyte browning in the evolution of endothermy [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2020 Endothermy changes the relationship between organisms and their environment fundamentally, and it is therefore of major ecological and evolutionary significance. Endothermy is characterized by non-shivering thermogenesis, that is metabolic heat production in the absence of muscular activity.
Martin Jastroch, Frank Seebacher
openaire +2 more sources
Adipocyte, 2022 Neuroblastoma (NB) is an embryonic malignant tumour of the sympathetic nervous system, and current research shows that activation of brown adipose tissue accelerates cachexia in cancer patients.
Zhijuan Ge +4 more
doaj +1 more source
The Therapeutic Potential of Brown Adipocytes in Humans [PDF]
Frontiers in Endocrinology, 2015 Obesity and its metabolic consequences represent a significant clinical problem. From a thermodynamic standpoint, obesity results from a discord in energy intake and expenditure. To date, lifestyle interventions based on reducing energy intake and/or increasing energy expenditure have proved ineffective in the prevention and/or treatment of obesity ...
Craig ePorter +6 more
openaire +5 more sources
Role of Ubiquilins for Brown Adipocyte Proteostasis and Thermogenesis [PDF]
Frontiers in Endocrinology, 2021 The acclimatization of brown adipose tissue (BAT) to sustained cold exposure requires an adaptive increase in proteasomal protein quality control. Ubiquilins represent a recently identified family of shuttle proteins with versatile functions in protein degradation, such as facilitating substrate targeting and proteasomal degradation.
Carolin Muley +5 more
openaire +5 more sources