P2X₅ receptor is functionally expressed on mouse brown adipocyte and can be a cell surface marker [PDF]
, 2016 Brown adipocytes expressed a large variety of purinergic receptor subtypes. We investigated about the expression of P2X5 receptor subtype among purinergic receptor subtypes expressed in mouse adipose tissue.Ca2+ imaging showed that applied 10 μM ATP or 1
ハヤト, リョウタロウ +4 more
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Differentiation of human adipose-derived stem cells into brite (brown-in-white) adipocytes
Frontiers in Endocrinology, 2011 It is well established now that adult humans possess active brown adipose tissue which represents a potential pharmacological target to combat obesity and associated diseases.
Didier F Pisani +6 more
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Bioactive Compounds and Adipocyte Browning Phenomenon
Current Issues in Molecular Biology, 2022 Overweight and obesity have become worldwide health issues in most countries. Current strategies aimed to prevent or reduce overweight and obesity have mainly focused on the genes and molecular mechanisms that give the functional characteristics to different types of adipose tissue.
Josué Manríquez-Núñez +1 more
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A novel crosstalk between Alk7 and cGMP signaling differentially regulates brown adipocyte function
Molecular Metabolism, 2015 Objective: Obesity is an enormous burden for patients and health systems world-wide. Brown adipose tissue dissipates energy in response to cold and has been shown to be metabolically active in human adults.
Aileen Balkow +5 more
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Loading and firing the brown adipocyte [PDF]
Adipocyte, 2017 Brown adipose tissue (BAT) is specialized to both store and expend chemical energy making it an ideal therapeutic target for various metabolic diseases. Fatty acids derived from lipid droplets within brown adipocytes acting on mitochondrial uncoupling protein 1 (UCP1) were long thought to be essential for non-shivering thermogenesis. Here, the roles of
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Lithium inhibits brown adipocyte differentiation [PDF]
FEBS Letters, 2005 Lithium impairs the appearance of the characteristic morphology of brown adipocytes and downregulates the expression of marker genes of brown adipocyte differentiation. These effects are dose‐dependent and are more pronounced when exposure of preadipocytes to lithium is initiated at early stages of differentiation.
Rodrı́guez de la Concepción, Maria Luisa +4 more
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Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade [PDF]
, 1994 The long-term hypoglycemic activity of sulphonylurea drugs has been attributed, in part at least, to the stimulation of glucose utilization in extra-pancreatic tissues. The novel sulphonylurea, glimepiride, gives rise to a longer lasting reduction in the
Wetekam, Eva-Marlen +5 more
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Dynamic regulation of genes involved in mitochondrial DNA replication and transcription during mouse brown fat cell differentiation and recruitment. [PDF]
PLoS ONE, 2009 BACKGROUND: Brown adipocytes are specialised in dissipating energy through adaptive thermogenesis, whereas white adipocytes are specialised in energy storage.
Maria Murholm +8 more
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Effects of exercise on brown and beige adipocytes
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019 Physical exercise leads to beneficial effects in numerous tissues and organ systems and offers protection against obesity and type 2 diabetes. Recent studies have investigated the role of exercise on brown adipose tissue (BAT) and white adipose tissue (WAT), and have indicated marked adaptations to each tissue with exercise.
Dewal, Revati S., Stanford, Kristin I.
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Adrenoceptors in white, brown, and brite adipocytes [PDF]
British Journal of Pharmacology, 2019 Adrenoceptors play an important role in adipose tissue biology and physiology that includes regulating the synthesis and storage of triglycerides (lipogenesis), the breakdown of stored triglycerides (lipolysis), thermogenesis (heat production), glucose metabolism, and the secretion of adipocyte‐derived hormones that can control whole‐body energy ...
Bronwyn A. Evans +3 more
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