Results 61 to 70 of about 39,242 (266)

Distinct expression of muscle-specific microRNAs (myomirs) in brown adipocytes [PDF]

, 2009
MicroRNAs, a novel class of post-transcriptional gene regulators, have been demonstrated to be involved in several cellular processes regulating the expression of protein-coding genes.
Nedergaard, Jan,, Keller, P, Nedergaard, J, Timmons, James A., Nedergaard, Jan, Stockholm University, Walden, T B, Timmons, J A, Keller, Pernille, Heriot-Watt, Walden, Tomas B., Timmons, James A, Walden, Tomas B,, Cannon, Barbara,, Cannon, B, Walden, Tomas B, Cannon, Barbara   +16 more
core   +1 more source

Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes

Cell Reports, 2019
Summary: White adipose tissue (WAT) is a central factor in the development of type 2 diabetes, but there is a paucity of translational models to study mature adipocytes.
Matthew J. Harms, Qian Li, Sunjae Lee, Cheng Zhang, Bengt Kull, Stefan Hallen, Anders Thorell, Ida Alexandersson, Carolina E. Hagberg, Xiao-Rong Peng, Adil Mardinoglu, Kirsty L. Spalding, Jeremie Boucher   +12 more
doaj   +1 more source

PPARγ in the control of brown adipocyte differentiation

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2005
The effects of fatty acids and retinoic acid (carotene) on brown adipose tissue differentiation are mediated by activation of the transcription factors PPARgamma and PPARalpha in combination with RXR. There is good support for the idea that activated PPARgamma promotes adipogenesis also in brown adipose tissue.
Nedergaard, Jan, Petrovic, Natasa, Lindgren, Eva M., Jacobsson, Anders, Cannon, Barbara   +4 more
openaire   +2 more sources

Histone acetylation modulates uncoupling protein1 expression in brown adipocytes [PDF]

, 2016
Uncoupling protein 1 (UCP1) is a classical feature of brown adipocytes and understanding its regulatory mechanism will help in the development of a pharmacological approach for obesity and associated metabolic diseases.
Rajan, Anubama
core   +2 more sources

IMPORTANCE OF IRON HOMEOSTASIS IN BEIGE AND BROWN ADIPOCYTES [PDF]

, 2021
Beige/brown adipocytes are specialized for non-shivering thermogenesis, dissipating mitochondrial energy into heat via uncoupling protein 1 (UCP1), thereby contributing to whole-body energy expenditure.
Yook, Jinseon
core   +1 more source

Difference in intracellular temperature rise between matured and precursor brown adipocytes in response to uncoupler and β-adrenergic agonist stimuli

Scientific Reports, 2017
Brown adipocytes function to maintain body temperature by heat production. However, direct measurement of heat production at a single cell level remains difficult.
Toshikazu Tsuji, Kumiko Ikado, Hideki Koizumi, Seiichi Uchiyama, Kazuaki Kajimoto   +4 more
doaj   +1 more source

mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue [PDF]

, 2016
Activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients.
Handschin, Christoph, Mitsugu Shimobayashi, Svensson, Kristoffer, Shimobayashi, Mitsugu, Muñoz, Sergio, Hall, Michael N., Verena Albert, Michael N Hall, Fatima Bosch, Albert, Verena, Kristoffer Svensson, Sergio Muñoz, Christoph Handschin, Bosch i Tubert, Fàtima, Colombi, Marco, Marco Colombi, Bosch, Fatima, Veronica Jimenez, Universitat Autònoma de Barcelona. Centre de Biotecnologia Animal i de Teràpia Gènica (CBATEG), Muñoz-Martínez, S, Jimenez, Veronica   +20 more
core   +1 more source

Characterization of immortalized human brown and white pre-adipocyte cell models from a single donor. [PDF]

PLoS ONE, 2017
Brown adipose tissue with its constituent brown adipocytes is a promising therapeutic target in metabolic disorders due to its ability to dissipate energy and improve systemic insulin sensitivity and glucose homeostasis.
Lasse K Markussen, Marie S Isidor, Peter Breining, Elise S Andersen, Nanna E Rasmussen, Louise I Petersen, Steen B Pedersen, Bjørn Richelsen, Jacob B Hansen   +8 more
doaj   +1 more source

SRF inhibits brown adipogenesis from brown pre-adipocytes. [PDF]

, 2017
(A) Cumulative distribution function (CDF) and (B) Heat Map demonstrating that mRNA expression of the targets activated by SRF is differentially regulated in brown adipose tissue stromal vascular fraction compared to mature brown adipocytes.
Lennart Opitz (86036), Christian Wolfrum (548967), Matthias Rosenwald (3709804), Vissarion Efthymiou (3709807)   +3 more
core   +1 more source

Shades of Brown: A Model for Thermogenic Fat

Frontiers in Endocrinology, 2015
Brown adipose tissue (BAT) is specialized to burn fuels to perform thermogenesis in defense of body temperature against cold. Recent discovery of metabolically active and relevant amounts of BAT in adult humans have made it a potentially attractive ...
Jon Michael Dempersmier, Hei Sook eSul
doaj   +1 more source