Results 61 to 70 of about 1,446,812 (280)
Characterization of immortalized human brown and white pre-adipocyte cell models from a single donor. [PDF]
PLoS ONE, 2017 Brown adipose tissue with its constituent brown adipocytes is a promising therapeutic target in metabolic disorders due to its ability to dissipate energy and improve systemic insulin sensitivity and glucose homeostasis.
Lasse K Markussen +8 more
doaj +1 more source
Histone acetylation modulates uncoupling protein1 expression in brown adipocytes [PDF]
, 2016 Uncoupling protein 1 (UCP1) is a classical feature of brown adipocytes and understanding its regulatory mechanism will help in the development of a pharmacological approach for obesity and associated metabolic diseases.
Rajan, Anubama
core +1 more source
Cold Exposure Induces Proliferation of Mature Brown Adipocyte in a ß3-Adrenergic Receptor-Mediated Pathway. [PDF]
PLoS ONE, 2016 Hyperplasia of brown adipose tissue (BAT) is a fundamental mechanism for adaptation to survive in the cold environment in rodents. To determine which cell types comprising BAT contribute to tissue hyperplasia, immunohistochemical analysis using a ...
Keigo Fukano +4 more
doaj +1 more source
Advanced Science, EarlyView.A minimally invasive optical window enables stable, long‐term imaging of peripheral nerves in vivo at single‐axon resolution. Dynamic processes of degeneration, regeneration, and cellular remodeling are visualized across multiple time scales within the same nerve region, providing a unique platform to study a variety of anatomical and molecular events ...
Igor D. Luzhansky +15 more
wiley +1 more source
Characterization of human bone marrow derived mesenchymal stem cells as a model for in vitro adipocytes studies [PDF]
, 2013 Overweight and obesity are major problems of public health in many countries worldwide. Overweight can cause severe diseases such as type II diabetes mellitus, hypertension, stroke, heart failure and several types of cancer.
Hirzel, Estelle
core +1 more source
Shades of Brown: A Model for Thermogenic Fat
Frontiers in Endocrinology, 2015 Brown adipose tissue (BAT) is specialized to burn fuels to perform thermogenesis in defense of body temperature against cold. Recent discovery of metabolically active and relevant amounts of BAT in adult humans have made it a potentially attractive ...
Jon Michael Dempersmier, Hei Sook eSul
doaj +1 more source
Journal of Lipid Research, 2023 Sphingosine 1-phosphate (S1P) has been implicated in brown adipose tissue (BAT) formation and energy consumption; however, the mechanistic role of sphingolipids, including S1P, in BAT remains unclear. Here, we showed that, in mice, BAT activation by cold
Jun-ichi Morishige +7 more
doaj +1 more source
Advanced Science, EarlyView.This study reveals that NOTCH2NLC transcript variant 2 generates PolyGN2C‐iso2, an aggregating protein present within intranuclear inclusions of NIID patient tissues. A novel mouse model expressing PolyGN2C‐iso2 recapitulates white matter abnormalities and cognitive deficits, mechanistically linked to mitochondrial dysfunction. These findings support a
Kang Zhang +22 more
wiley +1 more source
Lipid Droplets in Brown Adipose Tissue Are Dispensable for Cold-Induced Thermogenesis
Cell Reports, 2020 Summary: Brown adipocytes store metabolic energy as triglycerides (TGs) in lipid droplets (LDs). Fatty acids released from brown adipocyte LDs by lipolysis are thought to activate and fuel UCP1-mediated thermogenesis.
Chandramohan Chitraju +3 more
doaj +1 more source
Artepillin C, a Typical Brazilian Propolis-Derived Component, Induces Brown-Like Adipocyte Formation in C3H10T1/2 Cells, Primary Inguinal White Adipose Tissue-Derived Adipocytes, and Mice. [PDF]
PLoS ONE, 2016 Induction of brown-like adipocytes (beige/brite cells) in white adipose tissue (WAT) suggests a new approach for preventing and treating obesity via induction of thermogenesis associated with uncoupling protein 1 (UCP1).
Sho Nishikawa +9 more
doaj +1 more source