Results 51 to 60 of about 1,446,812 (280)

The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes

Journal of Lipid Research, 2012
White and brown adipocytes are believed to occupy different sites in the body. We studied the anatomical features and quantitative histology of the fat depots in obesity and type 2 diabetes-prone C57BL/6J mice acclimated to warm or cold temperatures ...
A. Vitali, I. Murano, M.C. Zingaretti, A. Frontini, D. Ricquier, S. Cinti   +5 more
doaj   +1 more source

ATP Release and Purinergic Signaling Potentiate β-Adrenergic Effects on Brown Adipocytes. [PDF]

Acta Physiol (Oxf)
ABSTRACT Aim Brown adipose tissue (BAT) specializes in energy consumption and thermogenesis in response to cold stress. Brown adipocytes (BA) express purinergic receptors, yet little is known about the source of extracellular ATP and the role of purinergic signaling, and the potential interaction with β‐adrenergic signaling.
Tozzi M, Berggreen EB, Zhang R, Gudiksen A, Li W, Matz MB, Pilegaard H, Hansen JB, Novak I.   +8 more
europepmc   +2 more sources

Regulatory mechanism of white adipocyte browning and research advances [PDF]

BIO Web of Conferences
Adipose tissue has energy storage and metabolic functions, and its content is highly correlated with an individual’s obesity status. The relative proportions of white adipocytes, brown adipocytes, and beige adipocytes are also important in regulating ...
Wang Zihan
doaj   +1 more source

β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes.

PLoS ONE, 2020
Boosting energy expenditure by harnessing the activity of brown adipocytes is a promising strategy for combatting the global epidemic of obesity. Many studies have revealed that the β3-adrenergic receptor agonist is a potent activator of brown adipocytes,
Kazuki Hattori, Hiroaki Wakatsuki, Chihiro Sakauchi, Shotaro Furutani, Sho Sugawara, Tomohisa Hatta, Tohru Natsume, Hidenori Ichijo   +7 more
doaj   +1 more source

Cinnamon induces browning in subcutaneous adipocytes [PDF]

Scientific Reports, 2017
AbstractBrowning is the process of increasing the number of brite cells, which helps to increase energy expenditure and reduce obesity. Consumption of natural and non-toxic herbal extracts that possess the browning effect is an attractive anti-obesity strategy. In this study, we examined the browning effect of cinnamon extract.
Hiu Yee Kwan, Jiahui Wu, Tao Su, Xiao-Juan Chao, Bin Liu, Xiuqiong Fu, Chi Leung Chan, Rebecca Hiu Ying Lau, Anfernee Kai Wing Tse, Quan Bin Han, Wang Fun Fong, Zhi-ling Yu   +11 more
openaire   +3 more sources

PPARγ in the control of brown adipocyte differentiation

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2005
The effects of fatty acids and retinoic acid (carotene) on brown adipose tissue differentiation are mediated by activation of the transcription factors PPARgamma and PPARalpha in combination with RXR. There is good support for the idea that activated PPARgamma promotes adipogenesis also in brown adipose tissue.
Nedergaard, Jan, Petrovic, Natasa, Lindgren, Eva M., Jacobsson, Anders, Cannon, Barbara   +4 more
openaire   +2 more sources

Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes

Cell Reports, 2019
Summary: White adipose tissue (WAT) is a central factor in the development of type 2 diabetes, but there is a paucity of translational models to study mature adipocytes.
Matthew J. Harms, Qian Li, Sunjae Lee, Cheng Zhang, Bengt Kull, Stefan Hallen, Anders Thorell, Ida Alexandersson, Carolina E. Hagberg, Xiao-Rong Peng, Adil Mardinoglu, Kirsty L. Spalding, Jeremie Boucher   +12 more
doaj   +1 more source

The role of melanocortins and cytokines in human adipose tissue and adipocytes [PDF]

, 2007
During the last decades obesity has become a major health problem in developed countries, and more recently also in the developing countries it is seriously affecting parts of the populations.
Hoch, Matthias
core   +1 more source

Difference in intracellular temperature rise between matured and precursor brown adipocytes in response to uncoupler and β-adrenergic agonist stimuli

Scientific Reports, 2017
Brown adipocytes function to maintain body temperature by heat production. However, direct measurement of heat production at a single cell level remains difficult.
Toshikazu Tsuji, Kumiko Ikado, Hideki Koizumi, Seiichi Uchiyama, Kazuaki Kajimoto   +4 more
doaj   +1 more source

The Role of Solute Carrier Transporters in Brown Adipocytes

, 2023
Adipose tissues, including white adipose tissue (WAT) and brown adipose tissue (BAT), play a critical role in regulating insulin sensitivity and energy homeostasis, making them potential targets for clinical interventions to fight against obesity.
Sucipto, Abby Kurniawati
core