A novel crosstalk between Alk7 and cGMP signaling differentially regulates brown adipocyte function
Molecular Metabolism, 2015 Objective: Obesity is an enormous burden for patients and health systems world-wide. Brown adipose tissue dissipates energy in response to cold and has been shown to be metabolically active in human adults.
Aileen Balkow +5 more
doaj +1 more source
Dynamic regulation of genes involved in mitochondrial DNA replication and transcription during mouse brown fat cell differentiation and recruitment. [PDF]
PLoS ONE, 2009 BACKGROUND: Brown adipocytes are specialised in dissipating energy through adaptive thermogenesis, whereas white adipocytes are specialised in energy storage.
Maria Murholm +8 more
doaj +1 more source
Stimulation of glucose utilization in 3T3 adipocytes and rat diaphragm in vitro by the sulphonylureas, glimepiride and glibenclamide, is correlated with modulations of the cAMP regulatory cascade [PDF]
, 1994 The long-term hypoglycemic activity of sulphonylurea drugs has been attributed, in part at least, to the stimulation of glucose utilization in extra-pancreatic tissues. The novel sulphonylurea, glimepiride, gives rise to a longer lasting reduction in the
Wetekam, Eva-Marlen +5 more
core +1 more source
The adipose organ of obesity-prone C57BL/6J mice is composed of mixed white and brown adipocytes
Journal of Lipid Research, 2012 White and brown adipocytes are believed to occupy different sites in the body. We studied the anatomical features and quantitative histology of the fat depots in obesity and type 2 diabetes-prone C57BL/6J mice acclimated to warm or cold temperatures ...
A. Vitali +5 more
doaj +1 more source
Cinnamon induces browning in subcutaneous adipocytes [PDF]
Scientific Reports, 2017 AbstractBrowning is the process of increasing the number of brite cells, which helps to increase energy expenditure and reduce obesity. Consumption of natural and non-toxic herbal extracts that possess the browning effect is an attractive anti-obesity strategy. In this study, we examined the browning effect of cinnamon extract.
Hiu Yee Kwan +11 more
openaire +3 more sources
Spatial Regulation of Reactive Oxygen Species via G6PD in Brown Adipocytes Supports Thermogenic Function [PDF]
, 2021 © 2021 by the American Diabetes Association.Reactive oxygen species (ROS) are associated with various roles of brown adipocytes. Glucose-6-phosphate dehydrogenase (G6PD) controls cellular redox potentials by producing NADPH.
Park, Isaac +11 more
core +3 more sources
Lipolysis stimulation brown adipocytes [PDF]
, 2020 Mouse brown adipocytes were pre-treated with vehicle or 10µM Atglistatin and 20µM CAY10499 (lipase inhib.) for 1h and subsequently stimulated with 100nM isoproterenol (ISO) or 20µM SR-3420 for 3 hrs before harvest.THIS DATASET IS ARCHIVED AT DANS/EASY ...
Markussen, L (via Mendeley Data)
core +1 more source
Regulatory mechanism of white adipocyte browning and research advances [PDF]
BIO Web of ConferencesAdipose tissue has energy storage and metabolic functions, and its content is highly correlated with an individual’s obesity status. The relative proportions of white adipocytes, brown adipocytes, and beige adipocytes are also important in regulating ...
Wang Zihan
doaj +1 more source
β-adrenergic receptor signaling evokes the PKA-ASK axis in mature brown adipocytes.
PLoS ONE, 2020 Boosting energy expenditure by harnessing the activity of brown adipocytes is a promising strategy for combatting the global epidemic of obesity. Many studies have revealed that the β3-adrenergic receptor agonist is a potent activator of brown adipocytes,
Kazuki Hattori +7 more
doaj +1 more source
L‐rhamnose induces browning in 3T3‐L1 white adipocytes and activates HIB1B brown adipocytes [PDF]
IUBMB Life, 2018 AbstractInduction of the brown adipocyte‐like phenotype in white adipocytes (browning) is considered as a novel strategy to fight obesity due to the ability of brown adipocytes to increase energy expenditure. Here, we report that L‐rhamnose induced browning by elevating expression levels of beige‐specific marker genes, including Cd137, Cited1, Tbx1 ...
Minji Choi +5 more
openaire +2 more sources