Brown adipogenic potential of brown adipocytes and peri-renal adipocytes from human embryo [PDF]
Scientific Reports, 2016 AbstractBoth brown adipocytes (BAC) and beige cells hold therapeutic potential for the treatment of metabolic disorders. Unfortunately, the amount and activity of these cells are limited in adults. Although BAC marker expression has been shown in peri-renal adipose tissues in children and adults, functional assessment is lacking.
Xin Wang +8 more
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Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes [PDF]
Journal of Biological Chemistry, 2015 Brown adipose tissue expends energy in the form of heat via the mitochondrial uncoupling protein UCP1. Recent studies showed that brown adipose tissue is present in adult humans and may be exploited for its anti-obesity and anti-diabetes actions. Apelin is an adipocyte-derived hormone that plays important roles in energy metabolism.
Than A. +6 more
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Bioactive Compounds and Adipocyte Browning Phenomenon
Current Issues in Molecular Biology, 2022 Overweight and obesity have become worldwide health issues in most countries. Current strategies aimed to prevent or reduce overweight and obesity have mainly focused on the genes and molecular mechanisms that give the functional characteristics to different types of adipose tissue.
Josué Manríquez-Núñez +1 more
openaire +3 more sources
PexRAP inhibits PRDM16-mediated thermogenic gene expression [PDF]
, 2017 How the nuclear receptor PPARγ regulates the development of two functionally distinct types of adipose tissue, brown and white fat, as well as the browning of white fat, remains unclear.
Dean, John M +8 more
core +3 more sources
β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis
JCI Insight, 2021 β3-Adrenergic receptors (β3-ARs) are the predominant regulators of rodent brown adipose tissue (BAT) thermogenesis. However, in humans, the physiological relevance of BAT and β3-AR remains controversial.
C. Cero +5 more
semanticscholar +1 more source
The corticotrophin-releasing factor/urocortin system regulates white fat browning in mice through paracrine mechanisms [PDF]
, 2015 Objectives: The corticotrophin-releasing factor (CRF)/urocortin system is expressed in the adipose tissue of mammals, but its functional role in this tissue remains unknown.
Clark, S. +10 more
core +3 more sources
Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders [PDF]
Diabetes & Metabolism Journal, 2016 Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte differentiation, the ...
So Hun Kim, Jorge Plutzky
doaj +1 more source
A Synergistic Antiobesity Effect by a Combination of Capsinoids and Cold Temperature Through Promoting Beige Adipocyte Biogenesis. [PDF]
, 2016 Beige adipocytes emerge postnatally within the white adipose tissue in response to certain environmental cues, such as chronic cold exposure. Because of its highly recruitable nature and relevance to adult humans, beige adipocytes have gained much ...
Bannai, Makoto +5 more
core +2 more sources
miR-155 regulates differentiation of brown and beige adipocytes via a bistable circuit [PDF]
, 2013 Brown adipocytes are a primary site of energy expenditure and reside not only in classical brown adipose tissue but can also be found in white adipose tissue.
Chen, Y. +6 more
core +1 more source
Lithium inhibits brown adipocyte differentiation [PDF]
FEBS Letters, 2005 Lithium impairs the appearance of the characteristic morphology of brown adipocytes and downregulates the expression of marker genes of brown adipocyte differentiation. These effects are dose‐dependent and are more pronounced when exposure of preadipocytes to lithium is initiated at early stages of differentiation.
Roser Iglesias +4 more
openaire +3 more sources