Results 21 to 30 of about 28,025 (237)
Brown adipogenic potential of brown adipocytes and peri-renal adipocytes from human embryo [PDF]
Scientific Reports, 2016 AbstractBoth brown adipocytes (BAC) and beige cells hold therapeutic potential for the treatment of metabolic disorders. Unfortunately, the amount and activity of these cells are limited in adults. Although BAC marker expression has been shown in peri-renal adipose tissues in children and adults, functional assessment is lacking.
Nan-Nan Wu +8 more
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Apelin Enhances Brown Adipogenesis and Browning of White Adipocytes [PDF]
Journal of Biological Chemistry, 2015 Brown adipose tissue expends energy in the form of heat via the mitochondrial uncoupling protein UCP1. Recent studies showed that brown adipose tissue is present in adult humans and may be exploited for its anti-obesity and anti-diabetes actions. Apelin is an adipocyte-derived hormone that plays important roles in energy metabolism.
Than A. +6 more
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Mitochondria in White, Brown, and Beige Adipocytes [PDF]
Stem Cells International, 2016 Mitochondria play a key role in energy metabolism in many tissues, including cardiac and skeletal muscle, brain, liver, and adipose tissue. Three types of adipose depots can be identified in mammals, commonly classified according to their colour appearance: the white (WAT), the brown (BAT), and the beige/brite/brown‐like (bAT) adipose tissues.
Miroslava Cedikova +7 more
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Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders [PDF]
Diabetes & Metabolism Journal, 2016 Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown adipocyte differentiation, the ...
So Hun Kim, Jorge Plutzky
doaj +1 more source
Role of Ubiquilins for Brown Adipocyte Proteostasis and Thermogenesis. [PDF]
Front Endocrinol (Lausanne), 2021 The acclimatization of brown adipose tissue (BAT) to sustained cold exposure requires an adaptive increase in proteasomal protein quality control. Ubiquilins represent a recently identified family of shuttle proteins with versatile functions in protein degradation, such as facilitating substrate targeting and proteasomal degradation.
Muley C, Kotschi S, Bartelt A.
europepmc +7 more sources
The Therapeutic Potential of Brown Adipocytes in Humans [PDF]
Frontiers in Endocrinology, 2015 Obesity and its metabolic consequences represent a significant clinical problem. From a thermodynamic standpoint, obesity results from a discord in energy intake and expenditure. To date, lifestyle interventions based on reducing energy intake and/or increasing energy expenditure have proved ineffective in the prevention and/or treatment of obesity ...
Craig ePorter +6 more
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Loading and firing the brown adipocyte [PDF]
Adipocyte, 2017 Brown adipose tissue (BAT) is specialized to both store and expend chemical energy making it an ideal therapeutic target for various metabolic diseases. Fatty acids derived from lipid droplets within brown adipocytes acting on mitochondrial uncoupling protein 1 (UCP1) were long thought to be essential for non-shivering thermogenesis. Here, the roles of
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Bioactive Compounds and Adipocyte Browning Phenomenon
Current Issues in Molecular Biology, 2022 Overweight and obesity have become worldwide health issues in most countries. Current strategies aimed to prevent or reduce overweight and obesity have mainly focused on the genes and molecular mechanisms that give the functional characteristics to different types of adipose tissue.
Josué Manríquez-Núñez +1 more
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Importance of adipocyte browning in the evolution of endothermy [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2020 Endothermy changes the relationship between organisms and their environment fundamentally, and it is therefore of major ecological and evolutionary significance. Endothermy is characterized by non-shivering thermogenesis, that is metabolic heat production in the absence of muscular activity.
Martin Jastroch, Frank Seebacher
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Mevalonate biosynthesis pathway regulates the development and survival of brown adipocytes
iScience, 2023 Summary: The high thermogenic activity of brown adipose tissue (BAT) has received considerable attention. Here, we demonstrated the role of the mevalonate (MVA) biosynthesis pathway in the regulation of brown adipocyte development and survival.
Jungin Kwon +15 more
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