Results 31 to 40 of about 29,253 (252)
Lithium inhibits brown adipocyte differentiation [PDF]
FEBS Letters, 2005 Lithium impairs the appearance of the characteristic morphology of brown adipocytes and downregulates the expression of marker genes of brown adipocyte differentiation. These effects are dose‐dependent and are more pronounced when exposure of preadipocytes to lithium is initiated at early stages of differentiation.
Rodrı́guez de la Concepción, Maria Luisa +4 more
openaire +2 more sources
Cell Reports, 2020 Summary: Brown adipose tissue (BAT) activity protects animals against hypothermia and represents a potential therapeutic target to combat obesity. The transcription factor early B cell factor-2 (EBF2) promotes brown adipocyte differentiation, but its ...
Anthony R. Angueira +9 more
doaj +1 more source
Effects of exercise on brown and beige adipocytes
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019 Physical exercise leads to beneficial effects in numerous tissues and organ systems and offers protection against obesity and type 2 diabetes. Recent studies have investigated the role of exercise on brown adipose tissue (BAT) and white adipose tissue (WAT), and have indicated marked adaptations to each tissue with exercise.
Dewal, Revati S., Stanford, Kristin I.
openaire +2 more sources
Adrenoceptors in white, brown, and brite adipocytes [PDF]
British Journal of Pharmacology, 2019 Adrenoceptors play an important role in adipose tissue biology and physiology that includes regulating the synthesis and storage of triglycerides (lipogenesis), the breakdown of stored triglycerides (lipolysis), thermogenesis (heat production), glucose metabolism, and the secretion of adipocyte‐derived hormones that can control whole‐body energy ...
Bronwyn A. Evans +3 more
openaire +2 more sources
Extracellular calcium modulates brown adipocyte differentiation and identity
Scientific Reports, 2017 Brown adipocytes are important in regulating non-shivering thermogenesis, whole body glucose and lipid homeostasis. Increasing evidence supports an important role of metabolites as well as macro- and micronutrients in brown adipocyte differentiation and ...
Ines Pramme-Steinwachs +2 more
doaj +1 more source
Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation
Cell Reports, 2019 Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases.
Alicia Mayeuf-Louchart +20 more
doaj +1 more source
Bmp4 Promotes a Brown to White-like Adipocyte Shift
Cell Reports, 2016 While Bmp4 has a well-established role in the commitment of mesenchymal stem cells into the adipogenic lineage, its role in brown adipocyte formation and activity is not well defined.
Salvatore Modica +11 more
doaj +1 more source
SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation
Cell Reports, 2019 Summary: Brown adipose tissue (BAT) is a thermogenic organ that maintains body temperature and energy homeostasis. Transcriptional regulation plays an important role in the program of brown adipogenesis.
Qiuli Liang +6 more
doaj +1 more source
Studying Brown Adipose Tissue in a Human in vitro Context
Frontiers in Endocrinology, 2020 New treatments for obesity and associated metabolic disease are increasingly warranted with the growth of the obesity pandemic. Brown adipose tissue (BAT) may represent a promising therapeutic target to treat obesity, as this tissue has been shown to ...
Isabella Samuelson +3 more
doaj +1 more source
Characterization of immortalized human brown and white pre-adipocyte cell models from a single donor. [PDF]
PLoS ONE, 2017 Brown adipose tissue with its constituent brown adipocytes is a promising therapeutic target in metabolic disorders due to its ability to dissipate energy and improve systemic insulin sensitivity and glucose homeostasis.
Lasse K Markussen +8 more
doaj +1 more source