Results 51 to 60 of about 1,141,798 (294)

Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes

Cell Reports, 2020
Summary: Brown adipose tissue (BAT) activity protects animals against hypothermia and represents a potential therapeutic target to combat obesity. The transcription factor early B cell factor-2 (EBF2) promotes brown adipocyte differentiation, but its ...
Anthony R. Angueira, Suzanne N. Shapira, Jeff Ishibashi, Samay Sampat, Jaimarie Sostre-Colón, Matthew J. Emmett, Paul M. Titchenell, Mitchell A. Lazar, Hee-Woong Lim, Patrick Seale   +9 more
doaj   +1 more source

Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation

Cell Reports, 2019
Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases.
Alicia Mayeuf-Louchart, Steve Lancel, Yasmine Sebti, Benoit Pourcet, Anne Loyens, Stéphane Delhaye, Christian Duhem, Justine Beauchamp, Lise Ferri, Quentin Thorel, Alexis Boulinguiez, Mathilde Zecchin, Julie Dubois-Chevalier, Jérôme Eeckhoute, Logan T. Vaughn, Peter J. Roach, Christian Dani, Bartholomew A. Pederson, Stéphane D. Vincent, Bart Staels, Hélène Duez   +20 more
doaj   +1 more source

Brown Adipocyte-Specific PPAR&ggr; (Peroxisome Proliferator-Activated Receptor &ggr;) Deletion Impairs Perivascular Adipose Tissue Development and Enhances Atherosclerosis in Mice

Arteriosclerosis, Thrombosis and Vascular Biology, 2018
Objective— Perivascular adipose tissue (PVAT) contributes to vascular homeostasis by producing paracrine factors. Previously, we reported that selective deletion of PPAR&ggr; (peroxisome proliferator-activated receptor &ggr;) in vascular smooth muscle ...
Wenhao Xiong, Xiangjie Zhao, L. Villacorta, O. Rom, Minerva T. Garcia-Barrio, Yanhong Guo, Yanbo Fan, Tianqing Zhu, Jifeng Zhang, R. Zeng, Y. E. Chen, Zhisheng Jiang, Lin Chang   +12 more
semanticscholar   +1 more source

Bmp4 Promotes a Brown to White-like Adipocyte Shift

Cell Reports, 2016
While Bmp4 has a well-established role in the commitment of mesenchymal stem cells into the adipogenic lineage, its role in brown adipocyte formation and activity is not well defined.
Salvatore Modica, Leon G. Straub, Miroslav Balaz, Wenfei Sun, Lukas Varga, Patrik Stefanicka, Milan Profant, Eric Simon, Heike Neubauer, Barbara Ukropcova, Jozef Ukropec, Christian Wolfrum   +11 more
doaj   +1 more source

Sulforaphane induces adipocyte browning and promotes glucose and lipid utilization [PDF]

, 2016
Scope: Obesity is closely related to the imbalance of white adipose tissue storing excess calories, and brown adipose tissue dissipating energy to produce heat in mammals.
Bao, Yong P., Chen, Fen, Chen, Shi Y, Fu, Jian F, Shan, Yu J, Wang, An S, Yao, An J, Zhang, Hui Q, Zhang, Xiao H, Zhao, Jin S, Zhou, Zu Q   +10 more
core   +1 more source

SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation

Cell Reports, 2019
Summary: Brown adipose tissue (BAT) is a thermogenic organ that maintains body temperature and energy homeostasis. Transcriptional regulation plays an important role in the program of brown adipogenesis.
Qiuli Liang, Quan Zheng, Yong Zuo, Yalan Chen, Jiao Ma, Peihua Ni, Jinke Cheng   +6 more
doaj   +1 more source

Undernutrition and stage of gestation influence fetal adipose tissue gene expression [PDF]

, 2015
Funded by the Scottish Government’s Rural and Environment Science and Analytical Services Division (RESAS), including the Strategic Partnership for Animal Science Excellence (SPASE) and the U.S. National Institutes of Health (HD045784).
Adam, Clare L, Aitken, Raymond P, Horgan, Graham W, Luther, Justin S, Milne, John S, Redmer, Dale A, Reynolds, Lawrence P., Wallace, Jacqueline M   +7 more
core   +1 more source

Studying Brown Adipose Tissue in a Human in vitro Context

Frontiers in Endocrinology, 2020
New treatments for obesity and associated metabolic disease are increasingly warranted with the growth of the obesity pandemic. Brown adipose tissue (BAT) may represent a promising therapeutic target to treat obesity, as this tissue has been shown to ...
Isabella Samuelson, Isabella Samuelson, Antonio Vidal-Puig, Antonio Vidal-Puig   +3 more
doaj   +1 more source

Characterization of immortalized human brown and white pre-adipocyte cell models from a single donor. [PDF]

PLoS ONE, 2017
Brown adipose tissue with its constituent brown adipocytes is a promising therapeutic target in metabolic disorders due to its ability to dissipate energy and improve systemic insulin sensitivity and glucose homeostasis.
Lasse K Markussen, Marie S Isidor, Peter Breining, Elise S Andersen, Nanna E Rasmussen, Louise I Petersen, Steen B Pedersen, Bjørn Richelsen, Jacob B Hansen   +8 more
doaj   +1 more source

Thermal stress induces glycolytic beige fat formation via a myogenic state. [PDF]

, 2019
Environmental cues profoundly affect cellular plasticity in multicellular organisms. For instance, exercise promotes a glycolytic-to-oxidative fibre-type switch in skeletal muscle, and cold acclimation induces beige adipocyte biogenesis in adipose tissue.
A Jaworski, AA Lans van der, Andrew Brack, Annarita Scaramozza, C Trapnell, Carlos Henrique Sponton, DC Berry, ES Bachman, H Ohno, J Nedergaard, J Sanchez-Gurmaches, J Wu, JR Arch, JZ Long, K Ikeda, K Nishijo, K Shinoda, Kazuki Tajima, Kenji Ikeda, Kosaku Shinoda, Kyeongkyu Kim, L Kazak, L Vishvanath, L Ye, LZ Sharp, M Razzoli, ME Lidell, MJ Hanssen, ML Gantner, MS Rodeheffer, P Cohen, P Seale, Qiang Wang, S Collins, S Heinz, S Jung, S Kajimura, S Tripathi, Shingo Kajimura, T Buch, T Yoneshiro, Takeshi Yoneshiro, VK Mootha, Y Hasegawa, YH Lee, YH Tseng, Yong Chen, Zachary Brown, ZF Yang   +48 more
core   +2 more sources