Results 51 to 60 of about 1,154,949 (367)

Brown adipose tissue whitening leads to brown adipocyte death and adipose tissue inflammation[S]

Journal of Lipid Research, 2018
In mammals, white adipose tissue (WAT) stores and releases lipids, whereas brown adipose tissue (BAT) oxidizes lipids to fuel thermogenesis. In obese individuals, WAT undergoes profound changes; it expands, becomes dysfunctional, and develops a low-grade
P. Kotzbeck, A. Giordano, E. Mondini, I. Murano, I. Severi, Wiebe Venema, M. P. Cecchini, E. Kershaw, G. Barbatelli, G. Haemmerle, R. Zechner, S. Cinti   +11 more
semanticscholar   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Early B Cell Factor Activity Controls Developmental and Adaptive Thermogenic Gene Programming in Adipocytes

Cell Reports, 2020
Summary: Brown adipose tissue (BAT) activity protects animals against hypothermia and represents a potential therapeutic target to combat obesity. The transcription factor early B cell factor-2 (EBF2) promotes brown adipocyte differentiation, but its ...
Anthony R. Angueira, Suzanne N. Shapira, Jeff Ishibashi, Samay Sampat, Jaimarie Sostre-Colón, Matthew J. Emmett, Paul M. Titchenell, Mitchell A. Lazar, Hee-Woong Lim, Patrick Seale   +9 more
doaj   +1 more source

Glycogen Dynamics Drives Lipid Droplet Biogenesis during Brown Adipocyte Differentiation

Cell Reports, 2019
Summary: Browning induction or transplantation of brown adipose tissue (BAT) or brown/beige adipocytes derived from progenitor or induced pluripotent stem cells (iPSCs) can represent a powerful strategy to treat metabolic diseases.
Alicia Mayeuf-Louchart, Steve Lancel, Yasmine Sebti, Benoit Pourcet, Anne Loyens, Stéphane Delhaye, Christian Duhem, Justine Beauchamp, Lise Ferri, Quentin Thorel, Alexis Boulinguiez, Mathilde Zecchin, Julie Dubois-Chevalier, Jérôme Eeckhoute, Logan T. Vaughn, Peter J. Roach, Christian Dani, Bartholomew A. Pederson, Stéphane D. Vincent, Bart Staels, Hélène Duez   +20 more
doaj   +1 more source

PON2 Deficiency Leads to Increased Susceptibility to Diet-Induced Obesity. [PDF]

, 2019
(1) Background: Paraoxonase 2 (PON2) is a ubiquitously expressed protein localized to endoplasmic reticulum and mitochondria. Previous studies have shown that PON2 exhibits anti-oxidant and anti-inflammatory functions, and PON2-deficient (PON2-def) mice ...
Fogelman, Alan M, Lusis, Aldons J, Meng, Yonghong, Reddy, Srinivasa T, Reue, Karen, Sallam, Tamer, Shih, Diana M, Shu, Michelle L, Tontonoz, Peter, Vergnes, Laurent   +9 more
core   +1 more source

Suppression of Brown Adipocyte Autophagy Improves Energy Metabolism by Regulating Mitochondrial Turnover

International Journal of Molecular Sciences, 2019
The high abundance of mitochondria and the expression of mitochondrial uncoupling protein 1 (UCP1) confer upon brown adipose tissue (BAT) the unique capacity to convert chemical energy into heat at the expense of ATP synthesis.
Donghwan Kim, Ji-Hye Kim, Young-Ho Kang, Je Seong Kim, Sung Yun, S. Kang, Youngsup Song   +6 more
semanticscholar   +1 more source

Bmp4 Promotes a Brown to White-like Adipocyte Shift

Cell Reports, 2016
While Bmp4 has a well-established role in the commitment of mesenchymal stem cells into the adipogenic lineage, its role in brown adipocyte formation and activity is not well defined.
Salvatore Modica, Leon G. Straub, Miroslav Balaz, Wenfei Sun, Lukas Varga, Patrik Stefanicka, Milan Profant, Eric Simon, Heike Neubauer, Barbara Ukropcova, Jozef Ukropec, Christian Wolfrum   +11 more
doaj   +1 more source

CREG1 stimulates brown adipocyte formation and ameliorates diet‐induced obesity in mice

The FASEB Journal, 2019
Increased formation of brown and beige adipocytes is critical for adaptive thermogenesis to maintain homeothermy in cold or to circumvent diet‐induced obesity (DIO). Cellular repressor of adenovirus early region 1A‐stimulated genes 1 (CREG1) exhibits the
M. Hashimoto, Tatsuya Kusudo, T. Takeuchi, N. Kataoka, T. Mukai, H. Yamashita   +5 more
semanticscholar   +1 more source

SENP2 Suppresses Necdin Expression to Promote Brown Adipocyte Differentiation

Cell Reports, 2019
Summary: Brown adipose tissue (BAT) is a thermogenic organ that maintains body temperature and energy homeostasis. Transcriptional regulation plays an important role in the program of brown adipogenesis.
Qiuli Liang, Quan Zheng, Yong Zuo, Yalan Chen, Jiao Ma, Peihua Ni, Jinke Cheng   +6 more
doaj   +1 more source

Brown Adipocyte-Specific PPAR&ggr; (Peroxisome Proliferator-Activated Receptor &ggr;) Deletion Impairs Perivascular Adipose Tissue Development and Enhances Atherosclerosis in Mice

Arteriosclerosis, Thrombosis and Vascular Biology, 2018
Objective— Perivascular adipose tissue (PVAT) contributes to vascular homeostasis by producing paracrine factors. Previously, we reported that selective deletion of PPAR&ggr; (peroxisome proliferator-activated receptor &ggr;) in vascular smooth muscle ...
Wenhao Xiong, Xiangjie Zhao, L. Villacorta, O. Rom, Minerva T. Garcia-Barrio, Yanhong Guo, Yanbo Fan, Tianqing Zhu, Jifeng Zhang, R. Zeng, Y. E. Chen, Zhisheng Jiang, Lin Chang   +12 more
semanticscholar   +1 more source