Results 151 to 160 of about 186,568 (350)

GRAF1 deficiency leads to defective brown adipose tissue differentiation and thermogenic response

open access: yesScientific Reports
Adipose tissue, which is crucial for the regulation of energy within the body, contains both white and brown adipocytes. White adipose tissue (WAT) primarily stores energy, while brown adipose tissue (BAT) plays a critical role in energy dissipation as ...
Xue Bai   +5 more
doaj   +1 more source

White-to-Beige and Back: Adipocyte Conversion and Transcriptional Reprogramming

open access: yesPharmaceuticals
Obesity has become a pandemic, as currently more than half a billion people worldwide are obese. The etiology of obesity is multifactorial, and combines a contribution of hereditary and behavioral factors, such as nutritional inadequacy, along with the ...
Stanislav Boychenko   +3 more
doaj   +1 more source

A Robust Multistep Digestion Method for Microplastics Detection in Human Tissue by MicroRaman Analysis

open access: yesDrug Testing and Analysis, EarlyView.
A unified digestion protocol for human biological samples has been developed for microplastics analysis by microRaman Spectroscopy. ABSTRACT The presence of microplastics (MPs) in human tissues has raised growing concerns, necessitating robust protocols for their reliable extraction and analysis.
Jennifer P. Pascali   +7 more
wiley   +1 more source

Brown and beige adipose tissue‐derived metabokine and lipokine inter‐organ signalling in health and disease

open access: yesExperimental Physiology
Adipose tissue has an established endocrine function through the secretion of adipokines. However, a role for bioactive metabolites and lipids, termed metabokines and lipokines, is emerging in adipose tissue‐mediated autocrine, paracrine and endocrine ...
Anna Malicka   +3 more
doaj   +1 more source

Novel pathways of heart failure with preserved ejection fraction [PDF]

open access: yes, 2016
INTRODUCTION: Diastolic heart failure (HF) i.e., HF with preserved ejection fraction (HFpEF) accounts for ~50% of all clinical HF presentations; but unlike systolic HF i.e., HF with reduced ejection fraction (HFrEF), there are no evidenced based ...
Li, Shanpeng
core   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito   +9 more
wiley   +1 more source

A Third Variable in Obesity: The Effects of Brown Adipose Tissue on Thermogenesis

open access: yes, 1981
Approaches to weight management which consider only energy intake and/or expenditure do not consistently lead to favorable outcomes. A third variable, thermogenesis, must also be considered in a comprehensive understanding of obesity· Three types of ...
McMinn, Mark R.
core  

Combinatorial expression of glial transcription factors induces Schwann cell‐specific gene expression in mouse embryonic fibroblasts

open access: yesDevelopmental Dynamics, EarlyView.
Abstract Background Schwann cells provide peripheral nerve trophic support, myelinate axons, and assist in repair. However, Schwann cell repair capacity is limited by chronic injury, disease, and aging. Schwann cell reprogramming is a cellular conversion strategy that could provide a renewable cell supply to repair injured nerves.
Lauren Belfiore   +7 more
wiley   +1 more source

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