Results 291 to 300 of about 1,390,341 (404)

Endothelial SIRT3 deficiency predisposes brown adipose tissue to whitening in diet-induced obesity. [PDF]

open access: yesInt J Biol Sci
Zhou Q   +19 more
europepmc   +1 more source

TRPM7 Deficiency Accelerates Vascular Senescence by Inhibiting H3K18 Lactylation

open access: yesAging Cell, EarlyView.
TRPM7 deficiency reduces lactate production in endothelial cells and downregulates both p300 expression and nuclear translocation. These changes collectively lead to decreased H3K18 lactylation levels. Consequently, this downregulates genes vital for vascular homeostasis while upregulating genes associated with aging and vascular remodeling (including ...
Yue Wang   +9 more
wiley   +1 more source

Caloric Restriction Reprograms Adipose Tissues in Rhesus Monkeys

open access: yesAging Cell, EarlyView.
Here we show shared and depot‐specific adaptations to life‐long CR in subcutaneous and visceral adipose depots from advanced‐age male rhesus monkeys. Transcriptomics reveal differences between the depots, as well as shared and distinct CR‐responsive pathways.
Josef P. Clark   +6 more
wiley   +1 more source

Perinatal Vitamin D Deficiency Enhances Brown Adipose Tissue Thermogenesis in Weanling Rats. [PDF]

open access: yesInt J Mol Sci
Moro ML   +8 more
europepmc   +1 more source

The use of infrared thermography in the measurement and characterization of brown adipose tissue activation

open access: yesTemperature, 2018
J. Law   +5 more
semanticscholar   +1 more source

Single‐Cell RNA Sequencing Identifies Accumulation of Fcgr2b + Virtual Memory‐Like CD8 T Cells With Cytotoxic and Inflammatory Potential in Aged Mouse White Adipose Tissue

open access: yesAging Cell, EarlyView.
Age‐associated accumulation of Fcgr2b + VM‐like CD8 T cells within visceral adipose tissue contributes to inflammation. ABSTRACT Aging and obesity are associated with pro‐inflammatory changes in adipose tissue. Overlapping mechanisms, such as the infiltration of inflammatory macrophages and T cells into visceral adipose tissue, have been implicated in ...
Archit Kumar   +3 more
wiley   +1 more source

Predicted functional alterations in colonic microbiota metabolism underlie ethanol consumption and preference behavior in mice

open access: yesAlcohol, Clinical and Experimental Research, EarlyView.
Using a free‐choice ethanol model, we show that mice switched from a high‐sugar/butter diet to AIN93G standard diet consume and prefer more alcohol than mice maintained on AIN93G. 16S profiling and inferred metabolome revealed reduced amino acid metabolism, increased secondary bile acid pathways, and lower microbiota‐derived SCFAs and selected amino ...
Mírian Velten Mendes   +7 more
wiley   +1 more source

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