Results 51 to 60 of about 186,568 (350)

Brown adipose tissue and thermogenesis [PDF]

Hormone Molecular Biology and Clinical Investigation, 2014
Abstract The growing understanding of adipose tissue as an important endocrine organ with multiple metabolic functions has directed the attention to the (patho)physiology of distinct fat depots. Brown adipose tissue (BAT), in contrast to bona fide white fat, can dissipate significant amounts of chemical energy through uncoupled ...
Anna, Fenzl, Florian W, Kiefer
openaire   +2 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Oxidative phosphorylation in brown adipose tissue in a type II diabetes mellitus mouse model after forced treadmill running

Бюллетень сибирской медицины
Aim. To study the effect of forced exercises on the content and parameters of oxidative phosphorylation in brown adipose tissue of mice with type II diabetes mellitus.Materials and methods.
A. N. Zakharova, K. G. Milovanova, A. A. Orlova, O. V. Kollantay, I. Yu. Shuvalov, L. V. Kapilevich   +5 more
doaj   +1 more source

Activation of classical brown adipocytes in the adult human perirenal depot is highly correlated with PRDM16-EHMT1 complex expression.

PLoS ONE, 2015
Brown fat generates heat to protect against cold and obesity. Adrenergic stimulation activates the thermogenic program of brown adipocytes. Although the bioactivity of brown adipose tissue in adult humans had been assumed to very low, several studies ...
Gaku Nagano, Haruya Ohno, Kenji Oki, Kazuhiro Kobuke, Tsuguka Shiwa, Masayasu Yoneda, Nobuoki Kohno   +6 more
doaj   +1 more source

Brown and Beige Fat: Therapeutic Potential in Obesity

Indonesian Biomedical Journal, 2014
BACKGROUND: The epidemic of obesity and type 2 diabetes presents a serious challenge to scientific and biomedical communities worldwide. There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the ...
Anna Meiliana, Andi Wijaya
doaj   +1 more source

Noggin depletion in adipocytes promotes obesity in mice. [PDF]

, 2019
ObjectiveObesity has increased to pandemic levels and enhanced understanding of adipose regulation is required for new treatment strategies. Although bone morphogenetic proteins (BMPs) influence adipogenesis, the effect of BMP antagonists such as Noggin ...
Blázquez-Medela, Ana M, Boström, Kristina I, Fogelman, Alan M, Guo, Yina, Jumabay, Medet, Lusis, Aldons J, Rajbhandari, Prashant, Reue, Karen, Sallam, Tamer, Tontonoz, Peter, Vergnes, Laurent, Wu, Xiuju, Yao, Jiayi, Yao, Yucheng, Zhang, Li   +14 more
core   +1 more source

Characterization of cold-induced remodelling reveals depot-specific differences across and within brown and white adipose tissues in mice [PDF]

, 2016
Brown and beige adipose tissues dissipate energy in the form of heat via mitochondrial uncoupling protein 1, defending against hypothermia and potentially obesity.
Atit, Aydin, Barbatelli, Barneda, Barnett, Bordicchia, Bostrom, Bukowiecki, Cannon, Cannon, Cao, Cederberg, Cinti, Cousin, Dallner, Fisher, Gautier, Gesta, Giannulis, Ishibashi, Jacobsson, Jakus, Lee, Lee, Lee, Lee, Lee, Lepper, Nakamura, Nedergaard, Nedergaard, Petrovic, Ravussin, Robidoux, Sanchez-Gurmaches, Sanchez-Gurmaches, Schulz, Seale, Seale, Shefer, Shore, Stephens, Timmons, Ukropec, Vaanholt, Vernochet, Virtue, Vitali, Waldén, Wang, Widberg, Xue, Yoo, Yu, Yu, Zhou   +55 more
core   +1 more source

Assessment of Skin in Patients With Systemic Sclerosis Using High‐Frequency Ultrasound and Shear Wave Elastography: A Comparative Study With Histology, Molecular, and Clinical Parameters

Arthritis Care &Research, EarlyView.
Objective Ultrasound (US) has been proposed as a potential tool for assessing skin fibrosis in systemic sclerosis (SSc). However, a large‐scale comparison of US‐based assessment with histologic markers of skin fibrosis has not been reported. We evaluated US‐based skin assessments for their face validity (differentiation between involved SSc and healthy
Ruhani Desai, Filemon Tan, Minghua Wu, Jeffery L. Browning, Samuel Theodore, Meng Zhang, Brian Skaug, Harshdeep Singh Chawla, Manmohan Singh, Salavat Aglyamov, Kirill V. Larin, Maureen Mayes, Shervin Assassi   +12 more
wiley   +1 more source

Early Overfeed-Induced Obesity Leads to Brown Adipose Tissue Hypoactivity in Rats

Cellular Physiology and Biochemistry, 2013
Background/Aims: Brown adipose tissue activation has been considered a potential anti-obesity mechanism because it is able to expend energy through thermogenesis. In contrast, white adipose tissue stores energy, contributing to obesity.
Douglas L. de Almeida, Gabriel S. Fabrício, Amanda B. Trombini, Audrei Pavanello, Laize P. Tófolo, Tatiane A. da Silva Ribeiro, Paulo C. de Freitas Mathias, Kesia Palma-Rigo   +7 more
doaj   +1 more source

A percutaneous needle biopsy technique for sampling the supraclavicular brown adipose tissue depot of humans. [PDF]

, 2015
Brown adipose tissue (BAT) has been proposed as a potential target tissue against obesity and its related metabolic complications. Although the molecular and functional characteristics of BAT have been intensively studied in rodents, only a few studies ...
Annamalai, P, Cesani, F, Chao, T, Chondronikola, M, Porter, C, Saraf, MK, Sidossis, LS   +6 more
core   +2 more sources