Results 81 to 90 of about 1,390,341 (404)

Global gene expression profiling of brown to white adipose tissue transformation in sheep reveals novel transcriptional components linked to adipose remodeling [PDF]

, 2015
BACKGROUND: Large mammals are capable of thermoregulation shortly after birth due to the presence of brown adipose tissue (BAT). The majority of BAT disappears after birth and is replaced by white adipose tissue (WAT).
Basse, Astrid L., Dixen, Karen, Gupta, Ramneek, Hansen, Jacob B., Kristiansen, Karsten, Quistorff, Bjorn, Qvortrup, Klaus, Tygesen, Malin P., Wang, Jun, Yadav, Rachita   +9 more
core   +3 more sources

Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity

Nature Network Boston, 2018
Adipocytes possess remarkable adaptive capacity to respond to nutrient excess, fasting or cold exposure, and they are thus an important cell type for the maintenance of proper metabolic health.
A. Bartelt, Scott B. Widenmaier, C. Schlein, Kornelia Johann, Renata L. S. Goncalves, K. Eguchi, Alexander W. Fischer, Güneş Parlakgül, Nicole A Snyder, Truc B Nguyen, Oliver T. Bruns, D. Franke, M. Bawendi, M. Lynes, L. O. Leiria, Y. Tseng, K. Inouye, A. P. Arruda, G. Hotamışlıgil   +18 more
semanticscholar   +1 more source

3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes

Advanced Biology, EarlyView.
In vitro cancer models are advantageous for studying important processes such as tumorigenesis, cancer growth, invasion, and metastasis. The complexity and biological relevance increase depending on the model structure, organization, and composition of materials and cells.
Kyndra S. Higgins, Ah Joung Yu, Cheryl T. Gomillion   +2 more
wiley   +1 more source

Glucocorticoid Receptor and Adipocyte Biology. [PDF]

, 2018
Glucocorticoids are steroid hormones that play a key role in metabolic adaptations during stress, such as fasting and starvation, in order to maintain plasma glucose levels.
Harris, Charles A, Lee, Rebecca A, Wang, Jen-Chywan   +2 more
core   +2 more sources

Deceptive Brown Adipose Tissue

Journal of the ASEAN Federation of Endocrine Societies
A 23-year-old female presented with headache, palpitation, and hypertensive spells. There was no similar family history. Twenty-four (24) hour urine testing showed elevated normetanephrine level with normal metanephrines [metanephrines 123 mcg/24 hrs (74-297); normetanephrines 5321.16 mcg/24 hrs (73-808)].
Biswajit Payra, Abhranil Dhar, Pankaj Singhania, Akshay Khatri, Pranab Kumar Sahana   +4 more
openaire   +3 more sources

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Conditional gene targeting using UCP1-Cre mice directly targets the central nervous system beyond thermogenic adipose tissues

Molecular Metabolism, 2022
Objective: Uncoupling protein 1 (UCP1) is a mitochondrial protein critical for adaptive thermogenesis in adipose tissues, and it is typically believed to be restricted to thermogenic adipose tissues.
Kristin E. Claflin, Kyle H. Flippo, Andrew I. Sullivan, Meghan C. Naber, Bolu Zhou, Tate J. Neff, Sharon O. Jensen-Cody, Matthew J. Potthoff   +7 more
doaj   +1 more source

Analysis of circadian pattern reveals tissue-specific alternative transcription in leptin signaling pathway [PDF]

, 2007
*Background* It has been previously reported that most mammalian genes display a circadian oscillation in their baseline expression. Consequently, the phase and amplitude of each component of a signal transduction cascade has downstream ...
A Savitzky, AA Ptitsyn, AA Ptitsyn, Andrey A Ptitsyn, AU Viola, BP Tu, E Selkov, E Selkov, H Yang, HR Ueda, JB Hogenesch, Jeffrey M Gimble, KF Storch, PJ Enriori, RR Klevecz, S Panda, S Zvonic, SN Archer   +17 more
core   +3 more sources

Circadian control of brown adipose tissue

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2021
Disruption of circadian (~24 h) rhythms is associated with an increased risk of cardiometabolic diseases. Therefore, unravelling how circadian rhythms are regulated in different metabolic tissues has become a prominent research focus. Of particular interest is brown adipose tissue (BAT), which combusts triglyceride-derived fatty acids and glucose into ...
Straat, M.E., Hogenboom, R., Boon, M.R., Rensen, P.C.N., Kooijman, S.   +4 more
openaire   +4 more sources

Versatile Cell Penetrating Peptide for Multimodal CRISPR Gene Editing in Primary Stem Cells

Advanced Functional Materials, EarlyView.
CRISPR machinery in diverse molecular formats (DNA, RNA, and ribonucleic protein) is complexed into nanoparticles with the cell‐friendly arginine‐alanine‐leucine‐alanine (RALA) cell‐penetrating peptide. Nanoparticles are delivered to primary mesenchymal stem cells ex vivo or locally in vivo to facilitate multimodal CRISPR gene editing. This RALA‐CRISPR
Joshua P. Graham, Jose Gabriel Castro, Lisette C. Werba, Joseph Amitrano, Luke Fardone, Kevin P. Francis, Anand Ramamurthi, Michael J. Layden, Helen O. McCarthy, Tomas Gonzalez‐Fernandez   +9 more
wiley   +1 more source