Results 101 to 109 of about 265 (109)

Molecular basis of histone H3K36me3 recognition by the PWWP domain of Brpf1

Nature Structural & Molecular Biology, 2010
Trimethylation of Lys36 in histone H3 (H3K36me3) coordinates events associated with the elongation phase of transcription and is also emerging as an important epigenetic regulator of cell growth and differentiation. We have identified the PWWP domain of bromo and plant homeodomain (PHD) finger-containing protein 1 (BRPF1) as a H3K36me3 binding module ...
Alessandro, Vezzoli, Nicolas, Bonadies, Mark D, Allen, Stefan M V, Freund, Clara M, Santiveri, Brynn T, Kvinlaug, Brian J P, Huntly, Berthold, Göttgens, Mark, Bycroft   +8 more
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Abstract 419: The development of BRPF1 degraders as a potential treatment for acute myeloid leukemia

Cancer Research, 2022
Abstract Acetylation of histones and additional nuclear proteins is a key mechanism in the regulation of gene expression. Aberrant acetylation has been linked to a wide range of diseases including cancer, inflammation, and neurodevelopmental disorders.
Daniel Joseph Glynn, Rosie Crampton, Thomas Pesnot, Andrew Scott, Anne-Chloe Nassoy, Ralph Kirk, Daniele Narducci, Gary Nelson, Lynette Ongiri, Habiba Begum, Vincent Rao, Matilda Bingham, Rhoanne McPherson, Darryl Turner   +13 more
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Development of small molecule inhibitors of BRPF1 and TRIM24 bromodomains

Drug Discovery Today: Technologies, 2016
The entry of small molecule inhibitors of the bromodomain and extra C-terminal domain (BET) family of bromodomains into the clinic has demonstrated the therapeutic potential for this class of epigenetic acetyl-lysine reader proteins. Within the past two years, the development of potent inhibitors for the bromodomain and PHD finger containing protein ...
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Ocular findings of BRPF1 variants: a case report and literature review

Journal of American Association for Pediatric Ophthalmology and Strabismus
Intellectual developmental disorder with dysmorphic facies and ptosis (IDDDFP) is a genetic disorder caused by variants in BRPF1. We report the case of a 2-year-old girl who presented with drooping of the left upper lid since birth and who was ultimately diagnosed with IDDDFP.
Lakshmi Soundarya Varsha Mallapragada, Verlyn Yang, Krishna Tumuluri   +2 more
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BRPF1-associated disease mimicking congenital myasthenic syndrome

Arquivos de Neuro-Psiquiatria
Case presentation: We describe a case of a two-year-old Haitian girl who presented with bilateral ptosis since birth. She is the first child of a non-consanguineous Haitian couple, born via vaginal delivery, at term, with no history of obstetric complications.
Mariana Hiromi Manoel Oku, Clara Gontijo Camelo, Cristiane de Araujo Martins Moreno, Raquel Diogenes Alencar Sindeaux, Gabriella Corrêa Dousseau, Gabriel Saboia de Araujo Torres, Edmar Zanoteli   +6 more
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Broadening the ocular phenotypic spectrum of ultra-rare BRPF1 variants: report of two cases

Ophthalmic Genetics
BRPF1 gene on 3p26-p25 encodes a protein involved in epigenetic regulation, through interaction with histone H3 lysine acetyltransferases KAT6A and KAT6B of the MYST family. Heterozygous pathogenic variants in BRPF1 gene are associated with Intellectual Developmental Disorder with Dysmorphic Facies and Ptosis (IDDDFP), characterized by global ...
Elisa Marziali, Samuela Landini, Erika Fiorentini, Camilla Rocca, Lucia Tiberi, Rosangela Artuso, Laila Zaroili, Elia Dirupo, Pina Fortunato, Sara Bargiacchi, Roberto Caputo, Giacomo Maria Bacci   +11 more
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A novel BRPF1 variant in a family with intellectual disability and dysmorphic face, from Çanakkale

2022
Sılan, Fatma, Akcan, Mehmet Berkay, Kaya, Derya, Ceylan Köse, Canan   +3 more
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Dual-target inhibitors based on brpf1: a review from medicinal chemistry perspectives

Medicinal Chemistry Research
Xuan Guan, Dan Mei, Xinyu Chen, Xiaodiao Li, Hongmei Yuan, Dan Zhou   +5 more
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The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity

Laue, K., Daujat, S., Crump, J., Plaster, N., Roehl, H., van Bebber, F., Busch-Nentwich, E., Dahm, R., Frohnhöfer, H., Geiger, H., Gilmour, D., Holley, S., Hooge, J.   +12 more
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