Results 81 to 90 of about 265 (109)
A new KAT on the block rewrites the epigenetic script in menin inhibitor‐resistant leukemia
HemaSphere, Volume 9, Issue 11, November 2025.
Yizhou Huang, Charles E. de Bock
wiley +1 more source
Molecular basis of histone acetyllysine recognition by the BRPF1 bromodomain (537.1)
The FASEB Journal, 2014 Covalent modifications on histone tails play a key role in determining the outcome of many nuclear processes including transcription, DNA repair, recombination, and replication. In humans, translocation of the monocytic leukemia zinc finger (MOZ) histone acetyltransferase (HAT) complex has been linked to a subtype of acute myeloid leukemia (AML).
openaire +1 more source
Multifunctional acyltransferase HBO1: a key regulatory factor for cellular functions
Cellular & Molecular Biology LettersHBO1, also known as KAT7 or MYST2, is a crucial histone acetyltransferase with diverse cellular functions. It typically forms complexes with protein subunits or cofactors such as MEAF6, ING4, or ING5, and JADE1/2/3 or BRPF1/2/3, where the BRPF or JADE ...
Zhanhuan Su +4 more
doaj +1 more source
Deregulation of bromodomain-containing proteins BRPF1 and BRD9 in hepatocellular carcinoma
, 2020 Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers worldwide. HCC treatment is very challenging, which is mainly due to the lack of early diagnostic tools and limited treatment options.
Cheng, Carol Lai Hung, 鄭麗紅
core
Characterisation of the interaction interface of the MOZ/BRPF1 acetyltransferase complex and its role in gene regulation [PDF]
, 2019 Monocytic leukaemia zinc-finger protein (MOZ) is a histone lysine acetyltransferase, which plays important roles in haematopoiesis and tissue development. Alterations of the Lysine (K) acetyl-transferase 6A (KAT6A) gene encoding (MOZ) are associated with
Mazumder, Bismoy
core
Characterisation of the interaction interface of the MOZ/BRPF1 acetyltransferase complex and its role in gene regulation [PDF]
Monocytic leukaemia zinc-finger protein (MOZ) is a histone lysine acetyltransferase, which plays important roles in haematopoiesis and tissue development. Alterations of the Lysine (K) acetyl-transferase 6A (KAT6A) gene encoding (MOZ) are associated with
Mazumder, Bismoy
core +2 more sources
Molecular mechanism(s) of di-acetyllysine recognition by the BRPF1 bromodomain
, 2019 Click on the Resource Link to find this item in the ACPHS Library catalog.Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive diseases such as cancer ...
Obi, Juliet O. '19
core +1 more source
, 2016 BRPF1 plays a scaffolding role in transcription. We report on fragment screening by high-throughput docking to the BRPF1 bromodomain which resulted in six chemotypes with very favorable ligand efficiency (0.45-0.50 kcal/mol per non-hydrogen atom). Twenty
Amedeo Caflisch (230949) +5 more
core +1 more source
, 2015 The bromodomain containing proteins TRIM24 (tripartite motif containing protein 24) and BRPF1 (bromodomain and PHD finger containing protein 1) are involved in the epigenetic regulation of gene expression and have been implicated in human cancer ...
Yanai Zhan (1586302) +43 more
core +1 more source
Clinical GeneticsABSTRACTIntellectual Developmental Disorder with Dysmorphic Facies and Ptosis (IDDDFP) is a rare autosomal dominant syndrome caused by pathogenic variants in the BRPF1 gene, which is critical for chromatin regulation. This study expands the clinical and molecular spectrum of IDDDFP by analysing 29 new patients from 20 families with confirmed BRPF1 ...
Colson, Cindy +21 more
openaire +3 more sources