Results 71 to 80 of about 265 (109)

Exploiting epigenetic targets to overcome taxane resistance in prostate cancer

Cell Death and Disease
The development of taxane resistance remains a major challenge for castration resistant prostate cancer (CR-PCa), despite the effectiveness of taxanes in prolonging patient survival.
Buse Cevatemre, Ipek Bulut, Beyza Dedeoglu, Arda Isiklar, Hamzah Syed, Ozlem Yedier Bayram, Tugba Bagci-Onder, Ceyda Acilan   +7 more
doaj   +1 more source

Adaptive functioning in children and young adults with monogenic neurodevelopmental disorders

Developmental Medicine &Child Neurology, Volume 67, Issue 7, Page 953-962, July 2025.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16264 Abstract Aim To examine the adaptive behaviour profiles of children with monogenic neurodevelopmental disorders (NDDs) to determine whether syndrome‐specific or transdiagnostic approaches provide a better understanding of the adaptive behavioural phenotypes of these NDDs ...
Emma K. Baker, Miya St John, Ruth Braden, Lottie D. Morison, Elana J. Forbes, Fatma Lelik, Stephen J. C. Hearps, David J. Amor, Angela T. Morgan   +8 more
wiley   +1 more source

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source

Truncated BRPF1 cooperates with Smoothened to promote adult Shh medulloblastoma

, 2020
Tumors are composed of proliferating cells that invade healthy tissue and grow over time. Even though it is still unclear, it is a common opinion that the cells of origin should possess a proliferative capacity (Blanpain, 2013; Visvader, 2011). Particularly for brain cancers, the transition of neural progenitors to differentiated postmitotic neurons is
openaire   +1 more source

Efficiency and Fidelity of Site-Directed Mutagenesis with Complementary Primer Pairs

Cells
Based on PCR with complementary primer pairs and Pfu DNA polymerase, QuickChange site-directed mutagenesis has been widely employed, but its efficiency varies from mutation to mutation. An alternative strategy relies on partially overlapping primer pairs
Paulina Varela-Castillo, Arezousadat Razavi, Negar Mousavi, Nicole Robinson, Xiang-Jiao Yang   +4 more
doaj   +1 more source

Mutations in Histone Acetylase Modifier BRPF1 Cause an Autosomal-Dominant Form of Intellectual Disability with Associated Ptosis

, 2017
Intellectual disability (ID) is a common neurodevelopmental disorder exhibiting extreme genetic heterogeneity, and more than 500 genes have been implicated in Mendelian forms of ID. We performed exome sequencing in a large family affected by an autosomal-
Vieville, G. (Gaëlle), Mark, Paul, Coutton, C. (Charles), Mark, P. (Paul), Von Allmen, G, Engelen, M. (Mark), Von Allmen, G. (Gretchen), Cobben, JM, Alders, M. (Marielle), Alders, Marielle, Magee, A. (Alex), Mattioli, F. (Francesca), Schaefer, E, Vieville, G, Dieterich, K, Magee, A, Juusola, J. (Jane), Cobben, Jan, Mandel, Jean-Louis, van Slegtenhorst, Marjon, Vieville, Gaëlle, Slegtenhorst, M.A. (Marjon) van, Von Allmen, Gretchen, Cobben, J.M. (Jan Maarten), Mattioli, F, Mattioli, Francesca, Cobben, Jan Maarten, Dieterich, Klaus, Dieterich, K. (Klaus), Juusola, Jane, Magee, Alex, Pujol, A, Alders, M, Mancini, Grazia M., Mandel, JL, Schaefer, E. (Elise), Piton, Amélie, Coutton, Charles, Pujol, A. (Aurora), Juusola, J, Pujol, Aurora, Coutton, C, Engelen, M, Mancini, Grazia, Schaefer, Elise, Engelen, Mark, Verheijen - Mancini, Grazia, Mark, P, Mandel, J.-L. (Jean-Louis), Piton, A. (Amélie), Piton, A, Mancini, G.M.S. (Grazia)   +51 more
core   +1 more source

Molecular Insights into Di‐acetyllysine Histone Recognition by the BRPF1 Bromodomain

The FASEB Journal, 2019
Bromodomains are often found in chromatin‐modifying complexes, whose activity can lead to aberrant expression of genes that drive certain diseases in humans, including cancer, neurological disorders and inflammation. The bromodomain‐PHD finger protein 1 (BRPF1) is a part of the MOZ (monocytic leukemic zinc‐finger protein) HAT (histone acetyltransferase)
openaire   +1 more source

Table_6_Transcriptional Networks Identify BRPF1 as a Potential Drug Target Based on Inflammatory Signature in Primary Lower-Grade Gliomas.xlsx

, 2021
Gliomas are the most common tumors of the central nervous system and are classified into grades I-IV based on their histological characteristics. Lower-grade gliomas (LGG) can be divided into grade II diffuse low-grade gliomas and grade III moderate ...
Huiyao Chen (7378727), Xinran Dong (464365), Tong Chen (188814), Wei Shi (68167), Ping Xue (167911), Duan Ma (40293), Yifeng Lin (40288), Mingyang Xia (11779799), Hao Li (31608), Wenhao Zhou (2855447)   +9 more
core   +1 more source

Investigate the role bromodomain- and plant homeodomain-linked zinc finger-containing protein 1 (BRPF1) plays in medulloblastoma [PDF]

, 2017
BACKGROUND: Medulloblastoma (MB) is the most common malignant brain tumor in children, accounting for 15-20% of all pediatric brain tumors. In patients with MB, prognosis depends heavily on the molecular makeup of the tumor.
Drozdowicz, Kelly
core   +1 more source

Genetic architecture and clinical features of Tourette syndrome in a child and adolescent cohort: an explorative clinical exome-based study

Frontiers in Psychiatry
BackgroundTourette Syndrome (TS) is a neurodevelopmental disorder with a complex genetic architecture, involving both rare high-impact variants and polygenic contributions.
Federica Saia, Federica Mirabella, Andrea Longhitano, Nicoletta Maugeri, Rita Barone, Renata Rizzo   +5 more
doaj   +1 more source