Results 41 to 50 of about 265 (109)

Targeting Proliferation Signals and the Cell Cycle Machinery in Acute Leukemias: Novel Molecules on the Horizon

Molecules, 2023
Uncontrolled proliferative signals and cell cycle dysregulation due to genomic or functional alterations are important drivers of the expansion of undifferentiated blast cells in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) cells ...
Andrea Ghelli Luserna di Rorà, Mouna Jandoubi, Giovanni Martinelli, Giorgia Simonetti   +3 more
doaj   +1 more source

Table_2_Deficiency of Intellectual Disability-Related Gene Brpf1 Attenuated Hippocampal Excitatory Synaptic Transmission and Impaired Spatial Learning and Memory Ability.XLSX

, 2021
Patients with monoallelic bromodomain and PHD finger-containing protein 1 (BRPF1) mutations showed intellectual disability. The hippocampus has essential roles in learning and memory.
Linya You (700541), Qiuyan Jin (4412839), Guoxiang Wang (396791), Guomin Zhou (377773), Jingli Cao (720669), Weiwei Xian (6171842), Xiangshan Yuan (11280261), Hang Zhang (106358)   +7 more
core   +1 more source

Molecular Insights into the Recognition of N-Terminal Histone Modifications by the BRPF1 Bromodomain [PDF]

Journal of Molecular Biology, 2014
The monocytic leukemic zinc finger (MOZ) histone acetyltransferase (HAT) acetylates free histones H3, H4, H2A, and H2B in vitro and is associated with up-regulation of gene transcription. The MOZ HAT functions as a quaternary complex with the bromodomain-PHD finger protein 1 (BRPF1), inhibitor of growth 5 (ING5), and hEaf6 subunits. BRPF1 links the MOZ
Amanda, Poplawski, Kaifeng, Hu, Woonghee, Lee, Senthil, Natesan, Danni, Peng, Samuel, Carlson, Xiaobing, Shi, Stefan, Balaz, John L, Markley, Karen C, Glass   +9 more
openaire   +2 more sources

Table_5_Deficiency of Intellectual Disability-Related Gene Brpf1 Attenuated Hippocampal Excitatory Synaptic Transmission and Impaired Spatial Learning and Memory Ability.XLSX

, 2021
Patients with monoallelic bromodomain and PHD finger-containing protein 1 (BRPF1) mutations showed intellectual disability. The hippocampus has essential roles in learning and memory.
Linya You (700541), Qiuyan Jin (4412839), Guoxiang Wang (396791), Guomin Zhou (377773), Jingli Cao (720669), Weiwei Xian (6171842), Xiangshan Yuan (11280261), Hang Zhang (106358)   +7 more
core   +1 more source

Deficiency of intellectual disability-related gene Brpf1 reduced inhibitory neurotransmission in MGE-derived GABAergic interneurons

G3: Genes, Genomes, Genetics, 2021
Intellectual disability is closely related to impaired GABA neurotransmission.
Jingli Cao, Weiwei Xian, Maierdan Palihati, Yu Zhu, Guoxiang Wang, Yunli Xie, Guomin Zhou, Linya You   +7 more
doaj   +1 more source

The pathological and functional roles of BRPF1 in hepatocellular carcinoma

Annals of Oncology, 2019
Abstract Background Bromodomain-containing proteins are important epigenetic regulators that specifically recognize acetylated histones and implicated in regulating gene expression. Bromodomain inhibitors showed a prominent therapeutic effect on metabolic diseases and various types of cancers in clinical trials. In this study, we employed RNA-Seq to
L.H.C. Cheng, F.H.C. Tsang, L. Wei, C.T. Law, I.O.L. Ng, C.M. Wong   +5 more
openaire   +1 more source

Table_1_Deficiency of Intellectual Disability-Related Gene Brpf1 Attenuated Hippocampal Excitatory Synaptic Transmission and Impaired Spatial Learning and Memory Ability.docx

, 2021
Patients with monoallelic bromodomain and PHD finger-containing protein 1 (BRPF1) mutations showed intellectual disability. The hippocampus has essential roles in learning and memory.
Linya You (700541), Qiuyan Jin (4412839), Guoxiang Wang (396791), Guomin Zhou (377773), Jingli Cao (720669), Weiwei Xian (6171842), Xiangshan Yuan (11280261), Hang Zhang (106358)   +7 more
core   +1 more source

Table_3_Deficiency of Intellectual Disability-Related Gene Brpf1 Attenuated Hippocampal Excitatory Synaptic Transmission and Impaired Spatial Learning and Memory Ability.XLSX

, 2021
Patients with monoallelic bromodomain and PHD finger-containing protein 1 (BRPF1) mutations showed intellectual disability. The hippocampus has essential roles in learning and memory.
Linya You (700541), Qiuyan Jin (4412839), Guoxiang Wang (396791), Guomin Zhou (377773), Jingli Cao (720669), Weiwei Xian (6171842), Xiangshan Yuan (11280261), Hang Zhang (106358)   +7 more
core   +1 more source

Bivalent interaction of the PZP domain of BRPF1 with the nucleosome impacts chromatin dynamics and acetylation [PDF]

Nucleic Acids Research, 2015
BRPF1 (bromodomain PHD finger 1) is a core subunit of the MOZ histone acetyltransferase (HAT) complex, critical for normal developmental programs and implicated in acute leukemias. BRPF1 contains a unique assembly of zinc fingers, termed a PZP domain, the physiological role of which remains unclear.
Klein, Brianna J., Muthurajan, Uma M., Lalonde, Marie-Eve, Gibson, Matthew D., Andrews, Forest H., Hepler, Maggie, Machida, Shinichi, Yan, Kezhi, Kurumizaka, Hitoshi, Poirier, Michael G., Côté, Jacques, Luger, Karolin, Kutateladze, Tatiana G.   +12 more
openaire   +2 more sources

A de novo BRPF1 variant in a case of Sudden Unexplained Death in Childhood

European Journal of Medical Genetics, 2020
Sudden Unexplained Death in Childhood (SUDC), the death of a child that remains unexplained after a complete autopsy and investigation, is a rare and poorly understood entity. This case report describes a 3-year-old boy with history of language delay and ptosis, who died suddenly in his sleep without known cause.
Christine, Keywan, Ingrid A, Holm, Annapurna, Poduri, Catherine A, Brownstein, Sanda, Alexandrescu, Jennifer, Chen, Christopher, Geffre, Richard D, Goldstein   +7 more
openaire   +3 more sources