Results 31 to 40 of about 265 (109)

Essential gene screening identifies the bromodomain-containing protein BRPF1 as a new actionable target for endocrine therapy-resistant breast cancers

Molecular Cancer
Identifying master epigenetic factors controlling proliferation and survival of cancer cells allows to discover new molecular targets exploitable to overcome resistance to current pharmacological regimens.
Annamaria Salvati, Giorgio Giurato, Jessica Lamberti, Ilaria Terenzi, Laura Crescenzo, Viola Melone, Luigi Palo, Alessandro Giordano, Francesco Sabbatino, Giuseppina Roscigno, Cristina Quintavalle, Gerolama Condorelli, Francesca Rizzo, Roberta Tarallo, Giovanni Nassa, Alessandro Weisz   +15 more
doaj   +2 more sources

Molecular Basis for the PZP Domain of BRPF1 Association with Chromatin [PDF]

Structure, 2020
The assembly of human histone acetyltransferase MOZ/MORF complexes relies on the scaffolding bromodomain plant homeodomain (PHD) finger 1 (BRPF1) subunit. The PHD-zinc-knuckle-PHD module of BRPF1 (BRPF1PZP) has been shown to associate with the histone H3 tail and DNA; however, the molecular mechanism underlying recognition of H3 and the relationship ...
Brianna J, Klein, Khan L, Cox, Suk Min, Jang, Jacques, Côté, Michael G, Poirier, Tatiana G, Kutateladze   +5 more
openaire   +2 more sources

Computational studies with flavonoids and terpenoids as BRPF1 inhibitors: in silico biological activity prediction, molecular docking, molecular dynamics simulations, MM/PBSA calculations [PDF]

, 2022
The BRPF1 protein is encoded by the BRPF1 gene. In addition, the BRPF1 gene is known to be upregulated in leukaemia. Recent studies have shown that it is also overexpressed in hepatocellular carcinoma (HCC) as well.
G. Yalçin-Özkat (13039102)
core   +2 more sources

Co-targeting of specific epigenetic regulators in combination with CDC7 potently inhibit melanoma growth

iScience, 2022
Summary: Melanoma is a highly aggressive skin cancer that frequently metastasizes, but current therapies only benefit some patients. Here, we demonstrate that the serine/threonine kinase cell division cycle 7 (CDC7) is overexpressed in melanoma, and ...
Suresh Chava, Suresh Bugide, Parmanand Malvi, Romi Gupta   +3 more
doaj   +1 more source

Case Report: A Case Report and Literature Review of 3p Deletion Syndrome

Frontiers in Pediatrics, 2021
Objective: The aim of the present study is to explore the clinical and genetic characteristics of 3p deletion syndrome to improve clinicians' understanding of the disease.Methods: The clinical manifestations, process of diagnosis and treatment, and ...
Junxian Fu, Ting Wang, Zhuo Fu, Tianxia Li, Xiaomeng Zhang, Jingjing Zhao, Guanglu Yang   +6 more
doaj   +1 more source

1,3-Dimethyl Benzimidazolones Are Potent, Selective Inhibitors of the BRPF1 Bromodomain [PDF]

ACS Medicinal Chemistry Letters, 2014
The BRPF (bromodomain and PHD finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes. Here, we report the discovery, binding mode, and structure-activity relationship (SAR) of the first potent, selective series of inhibitors of the BRPF1 bromodomain.
Emmanuel H, Demont, Paul, Bamborough, Chun-Wa, Chung, Peter D, Craggs, David, Fallon, Laurie J, Gordon, Paola, Grandi, Clare I, Hobbs, Jameed, Hussain, Emma J, Jones, Armelle, Le Gall, Anne-Marie, Michon, Darren J, Mitchell, Rab K, Prinjha, Andy D, Roberts, Robert J, Sheppard, Robert J, Watson   +16 more
openaire   +2 more sources

Identification of bromodomain-containing proteins prognostic value and expression significance based on a genomic landscape analysis of ovarian serous cystadenocarcinoma

Frontiers in Oncology, 2022
BackgroundOvarian serous cystadenocarcinoma (OSC), a common gynecologic tumor, is characterized by high mortality worldwide. Bromodomain (BRD)-containing proteins are a series of evolutionarily conserved proteins that bind to acetylated Lys residues of ...
Juan Zhang, Yan Li, Ting-yu Fan, Dan Liu, Wen-da Zou, Hui Li, Yu-kun Li   +6 more
doaj   +1 more source

Table_4_Deficiency of Intellectual Disability-Related Gene Brpf1 Attenuated Hippocampal Excitatory Synaptic Transmission and Impaired Spatial Learning and Memory Ability.XLSX

, 2021
Patients with monoallelic bromodomain and PHD finger-containing protein 1 (BRPF1) mutations showed intellectual disability. The hippocampus has essential roles in learning and memory.
Linya You (700541), Qiuyan Jin (4412839), Guoxiang Wang (396791), Guomin Zhou (377773), Jingli Cao (720669), Weiwei Xian (6171842), Xiangshan Yuan (11280261), Hang Zhang (106358)   +7 more
core   +1 more source

Structural and biophysical characterization of the nucleosome-binding PZP domain

STAR Protocols, 2021
Summary: The core subunit of the MORF acetyltransferase complex BRPF1 contains a unique combination of zinc fingers, including a plant homeodomain (PHD) finger followed by a zinc knuckle and another PHD finger, which together form a PZP domain (BRPF1PZP).
Brianna J. Klein, Khan L. Cox, Suk Min Jang, Rohit K. Singh, Jacques Côté, Michael G. Poirier, Tatiana G. Kutateladze   +6 more
doaj   +1 more source

Intellectual developmental disorder with dysmorphic facies and ptosis caused by copy number variation including the BRPF1 gene in Peruvian patient

Egyptian Journal of Medical Human Genetics, 2022
Background Intellectual developmental disorder with dysmorphic facies and ptosis (MIM #617333) is a very rare condition, characterized by more than 80% by language delay, intellectual disability, gross motor development delay, broad nasal bridge ...
Hugo H. Abarca-Barriga, Felix Chavesta Velásquez, Renzo Punil Luciano   +2 more
doaj   +1 more source