Results 11 to 20 of about 265 (109)

Truncated BRPF1 Cooperates with Smoothened to Promote Adult Shh Medulloblastoma [PDF]

Cell Reports, 2019
Summary: The transition of neural progenitors to differentiated postmitotic neurons is mainly considered irreversible in physiological conditions. In the present work, we show that Shh pathway activation through SmoM2 expression promotes postmitotic ...
Giuseppe Aiello, Claudio Ballabio, Riccardo Ruggeri, Luca Fagnocchi, Marica Anderle, Ilaria Morassut, Davide Caron, Francesca Garilli, Francesca Gianno, Felice Giangaspero, Silvano Piazza, Alessandro Romanel, Alessio Zippo, Luca Tiberi   +13 more
doaj   +4 more sources

Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer [PDF]

Communications Biology, 2021
Cheng et al. suggest that BRPF1 plays an oncogenic role in hepatocellular carcinoma (HCC), by controlling histone acetylation in the promoter regions of E2F2 and EZH2.
Carol Lai-Hung Cheng, Felice Hoi-Ching Tsang, Lai Wei, Mengnuo Chen, Don Wai-Ching Chin, Jialing Shen, Cheuk-Ting Law, Derek Lee, Carmen Chak-Lui Wong, Irene Oi-Lin Ng, Chun-Ming Wong   +10 more
doaj   +5 more sources

Deficient histone H3 propionylation by BRPF1-KAT6 complexes in neurodevelopmental disorders and cancer [PDF]

Science Advances, 2020
Lysine acetyltransferase 6A (KAT6A) and its paralog KAT6B form stoichiometric complexes with bromodomain- and PHD finger-containing protein 1 (BRPF1) for acetylation of histone H3 at lysine 23 (H3K23).
De Baere, Elfride, Solomon, Benjamin D., Lanpher, Brendan C., Savatt, Juliann, Mendelsohn, Bryce A., Hainlen, Meagan K., Gibson, Cynthia Forster, Eyal, Roy, Cadieux-Dion, Maxime, Riley, Alan F., Verdin, Hannah, Cross, Laura A., Hale, Rebecca J., Thiffault, Isabelle, Rousseau, Justine, Wagner, Monisa D., Callewaert, Bert, Machol, Keren, Bellus, Gary A., Potocki, Lorraine, Porter, Hillary M., Goverde, Anne, Yang, Xiang-Jiao, Engleman, Kendra L., Yan, Kezhi, Zhou, Dihong, Cho, Megan T., McWalter, Kirsty, Agre, Katherine E., Lewis, Andrea M., Campeau, Philippe M., Esber, Natacha   +31 more
core   +8 more sources

BRPF1 is essential for development of fetal hematopoietic stem cells [PDF]

Journal of Clinical Investigation, 2016
Hematopoietic stem cells (HSCs) serve as a life-long reservoir for all blood cell types and are clinically useful for a variety of HSC transplantation-based therapies. Understanding the role of chromatin organization and regulation in HSC homeostasis may
Li, Lin, Linya You, Edwin Wang, Lin Li, Jinfeng Zou, Nijnik, Anastasia, Yang, Xiang-Jiao, Kezhi Yan, You, Linya, Wang, Edwin, Yan, Kezhi, Xiang-Jiao Yang, Belle, Jad, Jad Belle, Anastasia Nijnik, Zou, Jinfeng   +15 more
core   +3 more sources

GSK6853, a Chemical Probe for Inhibition of the BRPF1 Bromodomain [PDF]

ACS Medicinal Chemistry Letters, 2016
The BRPF (Bromodomain and PHD Finger-containing) protein family are important scaffolding proteins for assembly of MYST histone acetyltransferase complexes.
Edward Hooper-Greenhill (2803273), David Lugo (2803279), Isabelle Becher (1357539), Armelle Le Gall (1343469), Robert J. Watson (1503289), Emmanuel H. Demont (1399288), Laurie J. Gordon (1343442), Peter D. Craggs (1343430), Paola Grandi (1343472), Anne-Marie Michon (1343457), Mark J. Bird (2803276), Chun-wa Chung (1343454), Paul Bamborough (1343466), Heather A. Barnett (2803291), Darren J. Mitchell (1343451), Robert J. Sheppard (1343445), Hawa Diallo (1432720), Rab K. Prinjha (449759), Allan J. B. Watson (1369614), David J. Fallon (2803285), Emma J. Jones (1665019), Clare I. Hobbs (2803288), Robert P. Law (2803282)   +22 more
core   +3 more sources

Deficiency of the chromatin regulator Brpf1 causes abnormal brain development [PDF]

Journal of Biological Chemistry, 2015
Epigenetic mechanisms are important in different neurological disorders, and one such mechanism is histone acetylation. The multivalent chromatin regulator BRPF1 (bromodomainand plant homeodomain-linked (PHD) zinc finger-containing protein 1) recognizes ...
Wang, Edwin, Bertos, Nicholas R., Park, Morag, Yang, Xiang-Jiao, Zou, Jinfeng, You, Linya, Zhao, Hong   +6 more
core   +3 more sources

The chromatin regulator Brpf1 regulates embryo development and cell proliferation [PDF]

Journal of Biological Chemistry, 2015
With hundreds of chromatin regulators identified in mammals, an emerging issue is how they modulate biological and pathological processes. BRPF1 (bromodomain-and PHD finger-containing protein 1) is a unique chromatin regulator possessing two PHD fingers,
Wang, Edwin, Bertos, Nicholas R., Yan, Kezhi, Park, Morag, Yang, Xiang-Jiao, Zou, Jinfeng, You, Linya, Zhao, Hong   +7 more
core   +3 more sources

Structure-based discovery of selective BRPF1 bromodomain inhibitors

European Journal of Medicinal Chemistry, 2018
Bromodomain and plant homeodomain (PHD) finger containing protein 1 (BRPF1) is a member of subfamily IV of the human bromodomains. Experimental evidence suggests that BRPF1 is involved in leukemia.
Chunxian Zhou, Zhou, Chunxian, Amedeo Caflisch, Zhu, Jian, Jian Zhu, Caflisch, Amedeo   +5 more
core   +6 more sources

Structural insights into recognition of acetylated histone ligands by the BRPF1 bromodomain [PDF]

FEBS Letters, 2014
Bromodomain-PHD finger protein 1 (BRPF1) is part of the MOZ HAT complex and contains a unique combination of domains typically found in chromatin-associated factors, which include plant homeodomain (PHD) fingers, a bromodomain and a proline-tryptophan ...
Glass, Karen C., Eckenroth, Brian E., Poplawski, Amanda, Chruszcz, Maksymilian, Lubula, Mulu Y., Carlson, Samuel   +5 more
core   +4 more sources

The multidomain protein Brpf1 binds histones and is required for Hox gene expression and segmental identity [PDF]

Development, 2008
The Trithorax group (TrxG) is composed of diverse, evolutionary conserved proteins that form chromatin-associated complexes accounting for epigenetic transcriptional memory.
Koblitzek, T., Hooge, J., Kirchner, A., Walker, A., Hagner, U., Kaps, E., Walderich, B., van Bebber, F., Seiler, C. ; https://orcid.org/, Busch-Nentwich, E. ; https://orcid.org/, Nüsslein-Volhard, C. ; https://orcid.org/, Söllner, C., Pezzuti, M., Schoenberger, U., Schlombs, K., Hennen, C., Dahm, R. ; https://orcid.org/, Maischein, H., Habeck, H., Kimmel, C., Nordin, R., Sonawane, M., Erker, P., Weiler, C., Knaut, H., Roehl, H. ; https://orcid.org/, Schneider, R., Maderspacher, F. ; https://orcid.org/, Hammerschmidt, M. ; https://orcid.org/, Loesche, C., Langenreich, U., Frohnhöfer, H. ; https://orcid.org/, Geiger, H., Vacun, G., Jülich, J., Trowe, T., Neumann, C., Nicolson, T. ; https://orcid.org/, Wehner, A., Odenthal, J., Plaster, N., Gilmour, S., deSatana-Stamm, J., Laue, K., Crump Gage, J., Holley, S. ; https://orcid.org/, Metzger, C., Daujat, S.   +47 more
core   +6 more sources