Results 1 to 10 of about 52 (52)

BRPF1 bridges H3K4me3 and H3K23ac in human embryonic stem cells and is essential to pluripotency

iScience, 2023
Summary: Post-translational modifications (PTMs) on histones play essential roles in cell fate decisions during development. However, how these PTMs are recognized and coordinated remains to be fully illuminated. Here, we show that BRPF1, a multi-histone
Cong Zhang, Huaisong Lin, Yanqi Zhang, Qi Xing, Jingyuan Zhang, Di Zhang, Yancai Liu, Qianyu Chen, Tiancheng Zhou, Junwei Wang, Yongli Shan, Guangjin Pan   +11 more
doaj   +1 more source

Deficiency of Intellectual Disability-Related Gene Brpf1 Attenuated Hippocampal Excitatory Synaptic Transmission and Impaired Spatial Learning and Memory Ability

Frontiers in Cell and Developmental Biology, 2021
Patients with monoallelic bromodomain and PHD finger-containing protein 1 (BRPF1) mutations showed intellectual disability. The hippocampus has essential roles in learning and memory.
Weiwei Xian, Jingli Cao, Xiangshan Yuan, Guoxiang Wang, Qiuyan Jin, Hang Zhang, Guomin Zhou, Guomin Zhou, Linya You, Linya You   +9 more
doaj   +1 more source

TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk

Hepatology, EarlyView., 2022
The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam, Jianqing Yu, Hao Huang, Xiaofan Ding, Alissa M. Wong, Howard H. Leung, Anthony W. Chan, Kelvin K. Ng, Mingjing Xu, Xin Wang, Nathalie Wong   +10 more
wiley   +1 more source

Deubiquitinase USP35 stabilizes BRPF1 to activate mevalonate (MVA) metabolism during prostate tumorigenesis

Cell Death Discovery, 2022
The mutual interplay between epigenetic modifications and metabolic rewiring contributes to malignant features of prostate adenocarcinoma (PRAD).
Guowen Lin, Tianrun Huang, Xiaobo Zhang, Gangmin Wang   +3 more
doaj   +1 more source

The MOZ-BRPF1 acetyltransferase complex in epigenetic crosstalk linked to gene regulation, development, and human diseases

Frontiers in Cell and Developmental Biology, 2023
Acetylation of lysine residues on histone tails is an important post-translational modification (PTM) that regulates chromatin dynamics to allow gene transcription as well as DNA replication and repair.
Tiina Viita, Jacques Côté
doaj   +1 more source

Mosaicism in BRPF1-Related Neurodevelopmental Disorder: Report of Two Sisters and Literature Review

Case Reports in Genetics, 2023
Bromodomain and PHD finger containing 1 (BRPF1)-related neurodevelopmental disorder is characterized by intellectual disability, developmental delay, hypotonia, dysmorphic facial features, ptosis, and blepharophimosis.
Khaliunaa Bayanbold, Georgianne Younger, Benjamin Darbro, Alpa Sidhu   +3 more
doaj   +1 more source

Transcriptional Networks Identify BRPF1 as a Potential Drug Target Based on Inflammatory Signature in Primary Lower-Grade Gliomas

Frontiers in Oncology, 2021
Gliomas are the most common tumors of the central nervous system and are classified into grades I-IV based on their histological characteristics. Lower-grade gliomas (LGG) can be divided into grade II diffuse low-grade gliomas and grade III moderate ...
Mingyang Xia, Huiyao Chen, Tong Chen, Ping Xue, Xinran Dong, Yifeng Lin, Duan Ma, Wenhao Zhou, Wenhao Zhou, Wenhao Zhou, Wei Shi, Hao Li   +11 more
doaj   +1 more source

The BRPF1 bromodomain is a molecular reader of di-acetyllysine

Current Research in Structural Biology, 2020
Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans.
Juliet O. Obi, Mulu Y. Lubula, Gabriel Cornilescu, Amy Henrickson, Kara McGuire, Chiara M. Evans, Margaret Phillips, Samuel P. Boyson, Borries Demeler, John L. Markley, Karen C. Glass   +10 more
doaj   +1 more source

Brpf1 Haploinsufficiency Impairs Dendritic Arborization and Spine Formation, Leading to Cognitive Deficits

Frontiers in Cellular Neuroscience, 2019
Haploinsufficiency of the bromodomain and PHD finger-containing protein 1 (BRPF1) gene causes intellectual disability (ID), which is characterized by impaired intellectual and cognitive function; however, the neurological basis for ID and the ...
Yan Su, Junhua Liu, Baocong Yu, Ru Ba, Chunjie Zhao   +4 more
doaj   +1 more source

Novel Missense Variant in Heterozygous State in the BRPF1 Gene Leading to Intellectual Developmental Disorder With Dysmorphic Facies and Ptosis

Frontiers in Genetics, 2020
Intellectual developmental disorder with dysmorphic facies and ptosis is an autosomal dominant condition characterized by delayed psychomotor development, intellectual disability, delayed speech, and dysmorphic facial features, mostly ptosis ...
Muhammad Imran Naseer, Muhammad Imran Naseer, Angham Abdulrahman Abdulkareem, Francisco J. Guzmán-Vega, Francisco J. Guzmán-Vega, Stefan T. Arold, Stefan T. Arold, Peter Natesan Pushparaj, Peter Natesan Pushparaj, Adeel G. Chaudhary, Adeel G. Chaudhary, Adeel G. Chaudhary, Mohammad H. AlQahtani, Mohammad H. AlQahtani   +13 more
doaj   +1 more source