Results 61 to 70 of about 25,250 (236)

Analysis of a Family with Brugada Syndrome and Sudden Cardiac Death Caused by a Novel Mutation of SCN5A

Cardiology Research and Practice, 2022
Background. Brugada syndrome is a hereditary cardiac disease associated with mutations in ion channel genes. The clinical features include ventricular fibrillation, syncope, and sudden cardiac death.
Yao-Bin Zhu, Jian-Hui Zhang, Yuan-Yuan Ji, Ya-Nan Hu, Han-Lu Wang, Dan-Dan Ruan, Xiao-Rong Meng, Xin-Fu Lin, Jie-Wei Luo, Wei Chen   +9 more
doaj   +1 more source

KCNQ1 Polymorphism in the Context of Ischemic Cardiomyopathy: A Potential Key to Decision‐Making for Device Implantation

Clinical Cardiology, Volume 48, Issue 5, May 2025.
Potassium Channels and Ventricular Arrhythmia Risk. Altered potassium channel function modifies cardiac repolarization: gain‐of‐function shortens, loss‐of‐function prolongs the QT interval. Both increase susceptibility to ventricular tachyarrhythmias, especially with myocardial scarring.
Uğur Özkan, Metin Budak, Muhammet Gürdoğan, Gülnur Öztürk, Mustafa Yildiz, Gökay Taylan, Servet Altay, Kenan Yalta   +7 more
wiley   +1 more source

Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients. [PDF]

, 2017
BACKGROUND: Data on the age at first arrhythmic event (AE) in Brugada syndrome are from limited patient cohorts. The aim of this study is 2-fold: (1) to define the age at first AE in a large cohort of patients with Brugada syndrome, and (2) to assess the
Aiba, T, Andorin, A, Arbelo, E, Behr, ER, Belhassen, B, Brugada, J, Brugada, P, Brugada, R, Calo, L, Casado-Arroyo, R, Champagne, J, Conte, G, Corrado, D, Delise, P, Denjoy, I, Gaita, F, Giustetto, C, Gourraud, J-B, Hirao, K, Hochstadt, A, Huang, Z, Juang, JJM, Kamakura, T, Kim, S-H, Kusano, KF, Leenhardt, A, Leshem, E, Mabo, P, Maeda, S, Michowitz, Y, Milman, A, Mizusawa, Y, Nam, G-B, Napolitano, C, Postema, PG, Priori, SG, Probst, V, Rahkovich, M, Sacher, F, Sarquella-Brugada, G, Takagi, M, Takahashi, Y, Tfelt-Hansen, J, Veltmann, C, Wijeyeratne, YD, Wilde, AAM, Yan, G-X   +46 more
core   +2 more sources

A Case of STEMI Masquerading Brugada Syndrome: Emphasizing the Importance of Clinical Decision Making in Emergencies

Journal of Investigative Medicine High Impact Case Reports, 2021
Brugada syndrome is a rare arrhythmogenic syndrome that is associated with an increased risk of ventricular fibrillation and sudden cardiac death. Electrocardiographic findings include patterns similar to a right bundle branch block (RBBB) and persistent
Nirmal Guragai MD, Rahul Vasudev MD, Dhaval Shah MD, Balraj Singh MD, Parminder Kaur MD, Ashen Fernando MD, Fayez Shamoon MD, Raja Pullatt MD, Meherwan Joshi MD, Preet Randhawa MD   +9 more
doaj   +1 more source

Extreme hypercalcemia secondary to parathyroid adenoma obscured by excessive coffee consumption and premature ventricular complexes

Journal of General and Family Medicine, Volume 26, Issue 3, Page 263-266, May 2025.
Diagnostic biases are potentially life‐threatening. We present a case of extreme hypercalcemia falsely diagnosed as premature ventricular complexes attributed to heavy coffee consumption, while symptoms and electrocardiographic findings of hypercalcemia were disregarded. Abstract Severe hypercalcemia has an arrhythmogenic effect. We present a case of a
Yuval Avidan, Sameer Kassem
wiley   +1 more source

Electrical Storms in Brugada Syndrome: Review of Pharmacologic and Ablative Therapeutic Options [PDF]

, 2005
Electrical storm occurring in a patient with the Brugada syndrome is an exceptional but malignant and potentially lethal event. Efficient therapeutic solutions should be known and urgently applied because of the inability of usual antiarrhythmic means in
Haïssaguerre, M, Hocini, M, Maury, P
core   +2 more sources

Abnormal ECG Findings in Athletes: Clinical Evaluation and Considerations. [PDF]

, 2019
PURPOSE OF REVIEW: Pre-participation cardiovascular evaluation with electrocardiography is normal practice for most sporting bodies. Awareness about sudden cardiac death in athletes and recognizing how screening can help identify vulnerable athletes have
A Biffi, A Biffi, A D’Silva, A D’Silva, A Magalski, A Malhotra, A Malhotra, A Malhotra, A Merghani, A Morshedi-Meibodi, A Pelliccia, A Pelliccia, A Zaidi, A Zaidi, A Zorzi, A Zorzi, A Zorzi, AD Desai, AL Aro, AL Rao, AO Usoro, BJ Maron, BJ Maron, C Antzelevitch, C Calore, C Daubert, C Miles, D Corrado, D Corrado, D Corrado, D Corrado, F D’Ascenzi, F Migliore, F Schnell, FI Marcus, G Finocchiaro, G Malfatto, G Mcclean, GJ Klein, GJ Klein, H Dhutia, H Morita, HUH Virk, J Basu, J Ehtisham, J Marek, J Novak, J Pei, J Steinfurt, JA Drezner, JA Drezner, KG Harmon, KM Park, L Calò, L Verdile, M Brosnan, M Papadakis, M Papadakis, M Sadron Blaye-Felice, MAE Haukilahti, Mark Abela, MG Wilson, MI Cohen, MJ Ackerman, MJ Brosnan, N Chandra, N Panhuyzen-goedkoop, N Sheikh, P Banankhah, PG Postema, PT Matusik, RE Bent, RE Eckart, S Gati, S Kapa, S Masrur, S Peters, S Sharma, S Viskin, Sanjay Sharma, SEE Page, T Senturk, X Li, YH Lee   +83 more
core   +1 more source

Matrine Inhibits the Wnt3a/β‐Catenin Signalling to Attenuate Pressure Overload‐Induced Atrial Remodelling and Vulnerability to Atrial Fibrillation

Journal of Cellular and Molecular Medicine, Volume 29, Issue 10, May 2025.
ABSTRACT Atrial fibrillation (AF) is closely associated with atrial electrical and structural remodelling, yet effective drug strategies remain limited. Matrine (MAT), the active compound in Sophora flavescens, has shown anti‐AF effects, but its mechanisms are unclear.
Guoxin Zhang, Xue Dong, Boxuan Sun, Zijun Zhou, Yinli Xu, Yuting Huang, Shan Meng, Zijun Cao, Nana Qin, Yan Zhu, Liming Yu, Huishan Wang   +11 more
wiley   +1 more source

Biophysical phenotypes of SCN5A mutations causing long QT and Brugada syndromes [PDF]

, 2000
Long QT and Brugada syndromes are two hereditary cardiac diseases. Brugada syndrome has so far been associated with only one gene, SCN5A, which encodes the cardiac sodium channel.
Baroudi, Ghayath, Chahine, Mohamed
core   +1 more source

Acquired Genotype‐Positive Long QT Syndrome After Pediatric Heart Transplantation

Pediatric Transplantation, Volume 29, Issue 3, May 2025.
ABSTRACT Background Congenital long QT syndrome (LQTS) is rare but significant, as it carries a risk for ventricular arrhythmias and sudden cardiac death. Its diagnosis can be made clinically by serial ECGs, ambulatory ECG monitoring, and exercise stress testing; however, genetic testing is confirmatory in the majority of cases.
Nicholas V. Barresi, Jessica Sebastian, Gaurav Arora, Brian Feingold   +3 more
wiley   +1 more source