Results 141 to 150 of about 1,175 (153)

Bruceantin and Brusatol: Molecular Insights and Therapeutic Promise of Quassinoids in Cancer Drug Discovery

Archiv der Pharmazie
ABSTRACT Cancer remains a leading cause of mortality worldwide, with treatment resistance posing a major obstacle to effective therapies. Natural compounds, including quassinoids such as bruceantin and brusatol, derived from Brucea javanica (L.) Merr., have demonstrated ...
Shumaila Ijaz, Javed Iqbal, Banzeer Ahsan Abbasi, Farishta Zarshan, Tabassum Yaseen, Zakir Ullah, Siraj Uddin, Sobia Kanwal, Tariq Mahmood, William N. Setzer, Javad Sharifi‐Rad, Daniela Calina   +11 more
openaire   +2 more sources

Constituents of Brucea sumatrana. I. Brusatol

The Journal of Organic Chemistry, 1968
Keng Yeow Sim, James J. Sims, Theodore A. Geissman   +2 more
openaire   +1 more source

KLF4 suppresses anticancer effects of brusatol via transcriptional upregulating NCK2 expression in melanoma

Biochemical Pharmacology
Brusatol (Bru), a main extract from traditional Chinese medicine Brucea javanica, has been reported to exist antitumor effect in many tumors including melanoma. However, the underlying mechanism in its anti-melanoma effect still need further exploration.
Xiaodong, Li, Yuankuan, Jiang, Ying, Wang, Na, Li, Shumeng, Zhang, Kejia, Lv, Renchuan, Jia, Tianfu, Wei, Xiaojie, Li, Chuanchun, Han, Jingrong, Lin   +10 more
openaire   +2 more sources

Exploring the Anti-Tumor Effects of Brusatol in Aggressive B-Cell Lymphomas

Aggressive B-cell lymphomas are the most common lymphoid malignancies in adults, with an increasing incidence. Diffuse large B-cell lymphoma (DLBCL) is the most prevalent and highly heterogeneous type, often exhibiting poor responses to standard immuno-chemotherapy.
Marta Malwina Szmyra-Połomka, Sandra Haingartner, Sonja Jantscher, Eva Maria Bernhart, Péter Kovács-Hajdu, Veronika Bošková, Nikolaus Krall, Antonella Zupo, Thomas Pircher, Katrin Pansy, Burkhard Klösch, Hildegard T. Greinix, Christine Beham-Schmid, Fotini Rosi Vagena, Martin Zacharias, Lukas Gaksch, Katharina Prochazka, Peter Neumeister, Michael A. Dengler, Alexander J.A. Deutsch   +19 more
openaire   +1 more source

HOXB9 a miR-122–5p regulated gene, suppressed the anticancer effects of brusatol by upregulating SCD1 expression in melanoma

Biomedicine and Pharmacotherapy, 2023
Ziming Guo, Yuankuan Jiang, Peng Lv
exaly  

Inhibition of Nrf2-mediated glucose metabolism by brusatol synergistically sensitizes acute myeloid leukemia to Ara-C

Biomedicine and Pharmacotherapy, 2021
Fang Yuan, Xiao-Ping Chen, Hong-Hao Zhou   +2 more
exaly  

Brusatol inhibits the growth of renal cell carcinoma by regulating the PTEN/PI3K/AKT pathway

Journal of Ethnopharmacology, 2022
Tao Wang, Zhiyuan Chen, Hui Chen
exaly  

Antitumour Quassinoids from Brucea javanica and SAR of Brusatol

Planta Medica, 2006
K Takeya, IH Kim, Y Hitotsuyanagi, T Hasuda   +3 more
openaire   +1 more source

Comprehensive anti-tumor effect of Brusatol through inhibition of cell viability and promotion of apoptosis caused by autophagy via the PI3K/Akt/mTOR pathway in hepatocellular carcinoma

Biomedicine and Pharmacotherapy, 2018
Qikuan He, Pengyi Guo, Yukai Xiang
exaly  

Determination of brusatol in plasma and tissues by LC–MS method and its application to a pharmacokinetic and distribution study in mice

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2017
Nan Guo, Fanlong Bu, Ruichen Guo
exaly