Results 131 to 140 of about 1,175 (153)

Brusatol-induced HL-60 cell differentiation involves NF-κB activation

Cancer Letters, 2004
Brusatol, a quassinoid isolated from the fruit of Brucea javanica, induces cell differentiation with various leukemic cell lines in the concentration range of 5-25 ng/ml. To investigate its mechanism of action, cultured HL-60 cells were treated with brusatol (25 ng/ml) for various periods of time and qualitatively analyzed for differential gene ...
Muriel Cuendet, Joell J Gills, John M Pezzuto   +2 more
exaly   +3 more sources

Nanoparticle Formulation of Brusatol: A Novel Therapeutic Option for Cancers

Journal of Pharmaceutics & Drug Delivery Research, 2018
Objective: Challenges to the use of brusatol for cancer chemotherapy include its reversible and short-lived effect on Nrf2 which is limited to a few hours, its non-selective inhibition of protein synthesis which renders it potentially toxic to non-cancerous cells resulting in adverse effects and poor water solubility.
Adesina SK, Reid TE
openaire   +1 more source

Anti-inflammatory Agents III: Structure–Activity Relationships of Brusatol and Related Quassinoids

Journal of Pharmaceutical Sciences, 1983
A series of quassinoids were observed to be potent inhibitors of induced inflammation and arthritis in rodents. Brusatol afforded the most potent activity followed by brucein-D. A 3-hydroxy-delta 3-2-oxo moiety in brusatol or a 1-hydroxy-delta 3-2-oxo moiety in brucein-D, as well as a C-15 ester-bearing delta-lactone ring in brusatol and C-11 and C-12 ...
I H Hall, Y Imakura
exaly   +3 more sources

Semisynthesis of fluorinated brusatol analogues and their cytotoxic activities

Tetrahedron
Brusatol analogues fluorinated at the C ring were synthesized to investigate the roles of the hydroxy groups at C-11 and C-12 in cytotoxic activity. Semisynthetic transformations of brusatol afforded 12-deoxy-12α-fluorobrusatol, 12-deoxy-12α-fluoro-9,11-dehydrobrusatol, 12-epi-11-oxobrusatol, 9,11-dehydrobrusatol, and (13S)-12-oxo-13(12→11α)-abeo ...
Huiyu Ren, Yu Tokumaru, Daiki Nojima, Haruhiko Fukaya, Hiroto Sato, Hyun-Sun Park, Yukio Hitotsuyanagi   +6 more
openaire   +1 more source

Brusatol modulates autophagy to ameliorate pulmonary fibrosis by targeting Nrf2 in silicosis

Phytomedicine
Silicosis is a progressive lung fibrosis caused by silica exposure, with impaired autophagic degradation of alveolar macrophages recognized as a key pathogenic mechanism. Brusatol (Bru), an active compound from traditional Chinese medicine, has been suggested to regulate autophagy, but its therapeutic role in silicosis remains unclear.A mouse silicosis
Huimin, Kang, Rou, Li, Housheng, Yang, Hanqin, Wang, Aoxiang, Hu, Guo, Chen, Xiya, Li, Shi, Chen   +7 more
openaire   +2 more sources

Reno-Protective Effects of Brusatol Against Renal Ischemia Reperfusion Injury

2021
Amaç: Bu çalışmanın amacı brusatol tedavisinin bilateral renal iskemi reperfüzyon (RIR) yöntemi ile indüklenen oksidatif böbrek hasarı üzerindeki potansiyel yararlı etkilerini belirlemektir.Gereç ve Yöntem: Mevcut çalışmada, deney hayvanları rastgele sham, renal iskemi reperfüzyonu (RIR), DMSO ve brusatol grupları olarak 4 gruba ayrıldı.
EKİNCİ AKDEMİR, Fazile Nur, TANYELİ, Ayhan, ERASLAN, Ersen, GÜLER, Mustafa Can, TOPDAĞI, Ömer, NACAR, Tuncer   +5 more
openaire   +2 more sources

Role of Brusatol in Preventing Gastrointestinal Cancer: Recent Trends and Future Perspectives

Archiv der Pharmazie
ABSTRACT Gastrointestinal (GI) cancers represent a major global health burden due to their high incidence and mortality. Brusatol has emerged as a promising natural anticancer agent with potent activity against diverse malignancies.
Falak Thakral, Rippin Sehgal, Gagandeep Singh, Gaganpreet Kaur, Shafiul Haque, Ritu Chauhan, Madhu Gupta, Hardeep Singh Tuli   +7 more
openaire   +2 more sources

Brusatol induces ferroptosis to inhibit hepatocellular carcinoma progression by targeting ATF3

Chemical Biology & Drug Design
AbstractFerroptosis is a novel form of programmed cell death that is triggered by iron‐dependent lipid peroxidation. Brusatol (BRU), a natural nuclear factor erythroid 2‐related factor 2 inhibitor, exhibits potent anticancer effects in various types of cancer.
Yuanyuan, Wan, Jingsong, Cheng, Debiao, Gan, Jiaming, He, An, Chen, Jing, Ma, Yunying, Li, Xiao, Wang, Jianhua, Ran, Dilong, Chen, Jing, Li   +10 more
openaire   +2 more sources

Targeting FOXM1/PSAT1 axis by Brusatol inhibits lung cancer malignant progression

Pathology - Research and Practice
Brusatol (BRU), an extract from Brucea javanica, has been found to inhibit cancer progression. However, the downstream targets of Brusatol and its underlying mechanisms in lung cancer still not fully elucidate and warrant further investigation. Here, we identified that Brusatol significantly downregulated the mRNA and protein levels of phosphoserine ...
Siyi, Ou, Xiaobo, Wang, Yulan, Sun, Yongfeng, Liang, Jing, Bai, Chuanchun, Han, Jing, Song   +6 more
openaire   +2 more sources

Brusatol enhances ferroptosis susceptibility in nasopharyngeal carcinoma by downregulating Nrf2 expression

European Journal of Pharmacology
Nasopharyngeal carcinoma (NPC) is characterized by high metastatic potential and invasiveness, posing significant therapeutic challenges. Existing treatment methods remain limited, and new therapeutic strategies are urgently needed. Brusatol, a natural quinoline-derived compound, exhibits broad pharmacological activities, including anti-cancer effects.
Mei Yang, Ziyi Zhang, Xin Su, Jiayu Li, Haoran Liu, Siqi Wang, Waleed Yousuf, Yingqiu Zhang, Shuang Guo, Dawei Li, Shuyan Liu   +10 more
openaire   +2 more sources