Results 111 to 120 of about 1,175 (153)

The implication of aberrant NRF2 activation in management of female cancers. [PDF]

Front Oncol
Kgatle M, Mbambara S, Fadebi O, Kabunda J, Kaoma C, Dlangalala T, Nxele S, Modipane N, Serite T, Mokoala K, Mashamba-Thompson T, Sathekge M.   +11 more
europepmc   +1 more source

New Brusatol Derivatives as Anti-Settlement Agents Against Barnacles, Targeting HSP90: Design, Synthesis, Biological Evaluation, and Molecular Docking Investigations. [PDF]

Int J Mol Sci
Jiang W, Luan T, Cao P, Ma Z, Su Z.
europepmc   +1 more source

NRF2-mediated persistent adaptation of oesophageal adenocarcinoma cells to HER2 inhibition. [PDF]

Oncogene
Zhang W, Lang J, Chattrakarn S, Wong CW, Li S, Kan K, Liu H, Gu W, Zhang J, Westermarck J, Whitmarsh AJ, Sharrocks AD, Tournier C.   +12 more
europepmc   +1 more source

The mechanism of the PI3K-AKT-mTOR signaling pathway in renal cell carcinoma: current developments and future prospects. [PDF]

Front Oncol
Zou C, Wang Y, Chen Q, Shi J, Wu X, Luo Q.   +5 more
europepmc   +1 more source

Brusatol Inhibits Esophageal Squamous Cell Carcinoma Tumorigenesis Through Bad-Mediated Mitochondrial Apoptosis Induction and Anti-Metastasis by Targeting Akt1. [PDF]

Biomolecules
Ji Y, Zhu X, Shi Y, Fang R, Sun Y, Ruan Y, Zhou L, Ge Y, Luo Q, Zhang J, Ma J.   +10 more
europepmc   +1 more source

The effect and mechanism of Germacrone in ameliorating alcoholic fatty liver by inhibiting Nrf2/Rbp4. [PDF]

Chin Med
Xiao R, Fang J, Huang Q, He G, Ou X, De Y, Gui S, Zhang Y, Wang M, Zhong Y, Zeren D, Long Y, Liu C, Xiong T.   +13 more
europepmc   +1 more source

Nrf2 in Pancreatic Cancer Chemotherapy Response and the Use of Brusatol as a Chemotherapeutic Agent

, 2017
Williams, D, Gana, T, Sivapalan, L, Butler, O, Jackson, R, Perez-Mancera, P, Barrera-Briceno, L, Copple, I, Cox, T, Goldring, C, Halloran, CM, Ghaneh, P, Palmer, D, Strobel, O, Greenhalf, W, Neoptolemos, JP, Costello, E   +16 more
openaire  

Brusatol: A potential sensitizing agent for cancer therapy from Brucea javanica

Biomedicine and Pharmacotherapy, 2023
Cancer is currently the most important problem endangering human health. As antitumor drugs have always been the most common methods for treating cancers, searching for new antitumor agents is of great significance. Brusatol, a quassinoid from the seeds of Brucea javanica, exhibits a potent tumor-suppressing effect with improved disease outcome ...
Fangli Zhou, Anping Su, Li Mi
exaly   +3 more sources

Brusatol: A potential anti-tumor quassinoid from Brucea javanica

Chinese Herbal Medicines, 2020
Brusatol, a triterpene lactone compound mainly from Brucea javanica, sensitizes a broad spectrum of cancer cells. It is known as a specific inhibitor of nuclear factor-erythroid 2-related factor 2 (Nrf2) pathway. In this review, we provide a comprehensive overview on the antitumor effect and molecular mechanisms of brusatol in vitro and in vivo.
Xin-Yue Shang, Guo-Dong Yao, Shao-Jiang Song   +2 more
exaly   +3 more sources